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Protein

Cysteine-rich with EGF-like domain protein 2

Gene

Creld2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May regulate transport of alpha4-beta2 neuronal acetylcholine receptor.By similarity

GO - Molecular functioni

Keywordsi

LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich with EGF-like domain protein 2
Gene namesi
Name:Creld2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1310614 Creld2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000025624723 – 349Cysteine-rich with EGF-like domain protein 2Add BLAST327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi137 ↔ 151PROSITE-ProRule annotation
Disulfide bondi145 ↔ 163PROSITE-ProRule annotation
Disulfide bondi165 ↔ 174PROSITE-ProRule annotation
Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi248N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi291 ↔ 305PROSITE-ProRule annotation
Disulfide bondi298 ↔ 314PROSITE-ProRule annotation
Disulfide bondi316 ↔ 327PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ4G063
PRIDEiQ4G063

PTM databases

iPTMnetiQ4G063
PhosphoSitePlusiQ4G063

Expressioni

Tissue specificityi

Broadly expressed in brain (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000004659
GenevisibleiQ4G063 RN

Interactioni

Subunit structurei

May interact with CHRNA4.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006357

Structurei

3D structure databases

ProteinModelPortaliQ4G063
SMRiQ4G063
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini133 – 175EGF-like 1PROSITE-ProRule annotationAdd BLAST43
Repeati190 – 237FU 1Add BLAST48
Repeati250 – 297FU 2Add BLAST48
Domaini287 – 328EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST42

Sequence similaritiesi

Belongs to the CRELD family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG4260 Eukaryota
ENOG41107X2 LUCA
GeneTreeiENSGT00680000100014
HOGENOMiHOG000004778
HOVERGENiHBG081344
InParanoidiQ4G063
OMAiCVGCTGK
OrthoDBiEOG091G09AA
PhylomeDBiQ4G063
TreeFamiTF316507

Family and domain databases

InterProiView protein in InterPro
IPR021852 DUF3456
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR006212 Furin_repeat
IPR009030 Growth_fac_rcpt_cys_sf
IPR002049 Laminin_EGF
PfamiView protein in Pfam
PF11938 DUF3456, 1 hit
PF07645 EGF_CA, 2 hits
SMARTiView protein in SMART
SM00181 EGF, 4 hits
SM00179 EGF_CA, 2 hits
SM00261 FU, 2 hits
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 2 hits
PS01187 EGF_CA, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4G063-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLLLAAGFG LLLLLLPPPA ASKKPTQCQR CRTLVDKFNQ GMANTARKNF
60 70 80 90 100
GGGNTAWEEK TLSKYEFSEI RLLEIMEGLC DSSDFECNQL LEQQEEQLEA
110 120 130 140 150
WWQSLKKDYP NLFEWFCVRT LKACCLPGTY GPDCKECQGG SERPCSGNGY
160 170 180 190 200
CSGDGSRQGD GSCQCHAGYK GPLCIDCMDG YFSLQRNETH SICLACDESC
210 220 230 240 250
KTCSGPSNKD CVQCEVGWAR VEDACVDVDE CAAETPPCSE AQYCENVNGS
260 270 280 290 300
YICEECDSTC VGCTGKGPAN CKECIAGYTK QSGQCADIDE CSLEEKACKR
310 320 330 340
RNENCYNVPG SFVCVCPDGF EETEDACVQT AQSEVTEENP TQPLSHEDL
Length:349
Mass (Da):38,251
Last modified:August 30, 2005 - v1
Checksum:i5E8ABE53CB9F8850
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098722 mRNA Translation: AAH98722.1
RefSeqiNP_001032285.1, NM_001037208.1
UniGeneiRn.19198

Genome annotation databases

EnsembliENSRNOT00000006357; ENSRNOP00000006357; ENSRNOG00000004659
GeneIDi362978
KEGGirno:362978

Similar proteinsi

Entry informationi

Entry nameiCREL2_RAT
AccessioniPrimary (citable) accession number: Q4G063
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: August 30, 2005
Last modified: April 25, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health