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Protein

Cysteine-rich with EGF-like domain protein 2

Gene

Creld2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May regulate transport of alpha4-beta2 neuronal acetylcholine receptor.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich with EGF-like domain protein 2
Gene namesi
Name:Creld2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1310614. Creld2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 349327Cysteine-rich with EGF-like domain protein 2PRO_0000256247Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi137 ↔ 151PROSITE-ProRule annotation
Disulfide bondi145 ↔ 163PROSITE-ProRule annotation
Disulfide bondi165 ↔ 174PROSITE-ProRule annotation
Glycosylationi187 – 1871N-linked (GlcNAc...)Sequence analysis
Glycosylationi248 – 2481N-linked (GlcNAc...)Sequence analysis
Disulfide bondi291 ↔ 305PROSITE-ProRule annotation
Disulfide bondi298 ↔ 314PROSITE-ProRule annotation
Disulfide bondi316 ↔ 327PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ4G063.
PRIDEiQ4G063.

PTM databases

iPTMnetiQ4G063.
PhosphoSiteiQ4G063.

Expressioni

Tissue specificityi

Broadly expressed in brain (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000004659.
GenevisibleiQ4G063. RN.

Interactioni

Subunit structurei

May interact with CHRNA4.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006357.

Structurei

3D structure databases

ProteinModelPortaliQ4G063.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini133 – 17543EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Repeati190 – 23748FU 1Add
BLAST
Repeati250 – 29748FU 2Add
BLAST
Domaini287 – 32842EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CRELD family.Curated
Contains 2 EGF-like domains.PROSITE-ProRule annotation
Contains 2 FU (furin-like) repeats.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG4260. Eukaryota.
ENOG41107X2. LUCA.
GeneTreeiENSGT00680000100014.
HOGENOMiHOG000004778.
HOVERGENiHBG081344.
InParanoidiQ4G063.
OMAiECDSTCV.
OrthoDBiEOG091G09AA.
PhylomeDBiQ4G063.
TreeFamiTF316507.

Family and domain databases

InterProiIPR021852. DUF3456.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_.
IPR002049. Laminin_EGF.
[Graphical view]
PfamiPF11938. DUF3456. 1 hit.
PF07645. EGF_CA. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 4 hits.
SM00179. EGF_CA. 2 hits.
SM00261. FU. 2 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4G063-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLLLAAGFG LLLLLLPPPA ASKKPTQCQR CRTLVDKFNQ GMANTARKNF
60 70 80 90 100
GGGNTAWEEK TLSKYEFSEI RLLEIMEGLC DSSDFECNQL LEQQEEQLEA
110 120 130 140 150
WWQSLKKDYP NLFEWFCVRT LKACCLPGTY GPDCKECQGG SERPCSGNGY
160 170 180 190 200
CSGDGSRQGD GSCQCHAGYK GPLCIDCMDG YFSLQRNETH SICLACDESC
210 220 230 240 250
KTCSGPSNKD CVQCEVGWAR VEDACVDVDE CAAETPPCSE AQYCENVNGS
260 270 280 290 300
YICEECDSTC VGCTGKGPAN CKECIAGYTK QSGQCADIDE CSLEEKACKR
310 320 330 340
RNENCYNVPG SFVCVCPDGF EETEDACVQT AQSEVTEENP TQPLSHEDL
Length:349
Mass (Da):38,251
Last modified:August 30, 2005 - v1
Checksum:i5E8ABE53CB9F8850
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098722 mRNA. Translation: AAH98722.1.
RefSeqiNP_001032285.1. NM_001037208.1.
UniGeneiRn.19198.

Genome annotation databases

EnsembliENSRNOT00000006357; ENSRNOP00000006357; ENSRNOG00000004659.
GeneIDi362978.
KEGGirno:362978.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098722 mRNA. Translation: AAH98722.1.
RefSeqiNP_001032285.1. NM_001037208.1.
UniGeneiRn.19198.

3D structure databases

ProteinModelPortaliQ4G063.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006357.

PTM databases

iPTMnetiQ4G063.
PhosphoSiteiQ4G063.

Proteomic databases

PaxDbiQ4G063.
PRIDEiQ4G063.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006357; ENSRNOP00000006357; ENSRNOG00000004659.
GeneIDi362978.
KEGGirno:362978.

Organism-specific databases

CTDi79174.
RGDi1310614. Creld2.

Phylogenomic databases

eggNOGiKOG4260. Eukaryota.
ENOG41107X2. LUCA.
GeneTreeiENSGT00680000100014.
HOGENOMiHOG000004778.
HOVERGENiHBG081344.
InParanoidiQ4G063.
OMAiECDSTCV.
OrthoDBiEOG091G09AA.
PhylomeDBiQ4G063.
TreeFamiTF316507.

Miscellaneous databases

PROiQ4G063.

Gene expression databases

BgeeiENSRNOG00000004659.
GenevisibleiQ4G063. RN.

Family and domain databases

InterProiIPR021852. DUF3456.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_.
IPR002049. Laminin_EGF.
[Graphical view]
PfamiPF11938. DUF3456. 1 hit.
PF07645. EGF_CA. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 4 hits.
SM00179. EGF_CA. 2 hits.
SM00261. FU. 2 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCREL2_RAT
AccessioniPrimary (citable) accession number: Q4G063
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: August 30, 2005
Last modified: September 7, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.