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Protein

Cell division cycle-associated 7-like protein

Gene

Cdca7l

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1 (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division cycle-associated 7-like protein
Gene namesi
Name:Cdca7l
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1564080. Cdca7l.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002493151 – 438Cell division cycle-associated 7-like proteinAdd BLAST438

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21PhosphoserineBy similarity1
Modified residuei74PhosphothreonineBy similarity1
Modified residuei76PhosphoserineBy similarity1
Modified residuei100PhosphoserineBy similarity1
Modified residuei103PhosphoserineBy similarity1
Modified residuei113PhosphoserineCombined sources1
Modified residuei135PhosphoserineBy similarity1
Modified residuei136PhosphoserineBy similarity1
Modified residuei183PhosphoserineBy similarity1
Modified residuei185PhosphoserineBy similarity1
Cross-linki210Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki213Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei249PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ4G059.
PRIDEiQ4G059.

PTM databases

iPTMnetiQ4G059.
PhosphoSitePlusiQ4G059.

Expressioni

Gene expression databases

BgeeiENSRNOG00000005410.
ExpressionAtlasiQ4G059. baseline and differential.
GenevisibleiQ4G059. RN.

Interactioni

Subunit structurei

Interacts with MYC and PSIP1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061054.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni55 – 114PSIP1-bindingBy similarityAdd BLAST60
Regioni201 – 223MYC-bindingBy similarityAdd BLAST23

Phylogenomic databases

eggNOGiENOG410IYXY. Eukaryota.
ENOG410XQV7. LUCA.
GeneTreeiENSGT00390000014657.
HOGENOMiHOG000231812.
HOVERGENiHBG060300.
InParanoidiQ4G059.
OMAiLGNTCHQ.
OrthoDBiEOG091G0A11.
PhylomeDBiQ4G059.
TreeFamiTF101076.

Family and domain databases

InterProiView protein in InterPro
IPR033578. CDCA7L.
IPR018866. Znf-4CXXC_R1.
PANTHERiPTHR31169:SF8. PTHR31169:SF8. 1 hit.
PfamiView protein in Pfam
PF10497. zf-4CXXC_R1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4G059-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELATRSQIP KEVADIFNAP SDDEEFVGFQ DDVPMENLSE SCGSLDSLEL
60 70 80 90 100
EKQNACLHSK YFTEELRRIF KEDTDSDNED FEGFTESELN IGSNPELIES
110 120 130 140 150
ELSDGDKTHP MMSDEEDDDD EEEAAPRRGR QSTRSSFGLR VAFQFPTKKT
160 170 180 190 200
AKTPDKNSPH LLGGKTDLRR EKSCRQPKEK EDSASDAEDE SRAESQETSD
210 220 230 240 250
ALLKRAMNIK ENKAMLAQLL AELNSVPDFF PVRTPPSASR RRTPRRAFSE
260 270 280 290 300
GQITRRVNPT RSARPPEKFA LENFTFSATK LTEELYSFRR RKTISGGKCQ
310 320 330 340 350
KYRRHRISSF RSVKDITEEE LENIAITVRD KVYDKVLGNT CHQCRQKTID
360 370 380 390 400
TKTVCRNQGC GGVRGQFCGP CLRNRYGEDV RTALLDPKWT CPPCRGICNC
410 420 430
SYCRRRDGRC ATGILIHLAK FYGYDNVKEY LESLQKQL
Length:438
Mass (Da):49,973
Last modified:August 30, 2005 - v1
Checksum:i33D13AF4DE7F9612
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098734 mRNA. Translation: AAH98734.1.
RefSeqiNP_001030125.1. NM_001034953.1.
UniGeneiRn.201759.

Genome annotation databases

EnsembliENSRNOT00000064868; ENSRNOP00000061054; ENSRNOG00000005410.
GeneIDi619566.
KEGGirno:619566.
UCSCiRGD:1564080. rat.

Similar proteinsi

Entry informationi

Entry nameiCDA7L_RAT
AccessioniPrimary (citable) accession number: Q4G059
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: August 30, 2005
Last modified: August 30, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome