Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

PX domain-containing protein kinase-like protein

Gene

Pxk

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
PX domain-containing protein kinase-like protein
Alternative name(s):
Modulator of Na,K-ATPase
Short name:
MONaKA
Gene namesi
Name:PxkImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi727819. Pxk.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2176805.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 580580PX domain-containing protein kinase-like proteinPRO_0000086594Add
BLAST

Proteomic databases

PaxDbiQ4FZZ1.

PTM databases

iPTMnetiQ4FZZ1.

Expressioni

Gene expression databases

GenevisibleiQ4FZZ1. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010763.

Structurei

3D structure databases

ProteinModelPortaliQ4FZZ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 126113PXPROSITE-ProRule annotationAdd
BLAST
Domaini88 – 481394Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini549 – 56820WH2PROSITE-ProRule annotationAdd
BLAST

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Belongs to the protein kinase superfamily.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation
Contains 1 WH2 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IF7B. Eukaryota.
ENOG410Z20X. LUCA.
HOGENOMiHOG000230568.
HOVERGENiHBG061245.
InParanoidiQ4FZZ1.
KOiK17543.
OMAiLESICKF.
OrthoDBiEOG7FFMRQ.
PhylomeDBiQ4FZZ1.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR001683. Phox.
IPR000719. Prot_kinase_dom.
IPR003124. WH2_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00787. PX. 1 hit.
PF02205. WH2. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50195. PX. 1 hit.
PS51082. WH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4FZZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFMEKPPAR KVLLDDTVPL TAAVEASQSL QSHTEYIIRV QRGISAENSW
60 70 80 90 100
QIVRRYSDFD LLNNSLQITG LSLPLPPKKL IGNMDREFIA ERQKGLQNYL
110 120 130 140 150
NVIMANHVLS NCELLKKFLD PNNYSANYTE IALQQVSMFF RSEPKWEVVE
160 170 180 190 200
PLKDIGWRIR KKYFLMKIKN QPKERLVLSW ADLGPDKYLS DKDFQCLIKL
210 220 230 240 250
LPSCVHPYIY RVTFATASES SALLIRTFND KGTLKDLIYK AKPKDPFLKK
260 270 280 290 300
YCNPKKTQGL ELQQIKTYGR QILEVLKFLH DKGFPYGHLH AANVMLDGNT
310 320 330 340 350
CRLLDLENSL LGLPSFYRSY FTQFRKINTL ESVDVHCFGH LLYEMTYGRP
360 370 380 390 400
PDSVPVDSFP PASSMAVVAV LESTLSCEAC KNGMPTVSRL LQMPLFSDVL
410 420 430 440 450
LTTSEKPQFK IPTKLREALR IAKECIEKRL TEEQKQIHQH RRLTRAQSHH
460 470 480 490 500
GSEEERKRRK ILARKKSKRS AVENSEEQPV KHSNANNSAG SGASSPLTSP
510 520 530 540 550
SSPTPPSTAG LSSALPPPPP PPPPPPPPAG PSPGTEMPAP PLPQAVNGVN
560 570 580
RGALLSSIQN FQKGTLRKAK TCDHSAPKIG
Length:580
Mass (Da):65,098
Last modified:August 30, 2005 - v1
Checksum:iC40F1923DC99C1BB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti489 – 4891Missing in AAP92800 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY327408 mRNA. Translation: AAP92800.1.
BC098901 mRNA. Translation: AAH98901.1.
RefSeqiNP_877973.1. NM_182821.1.
XP_006251837.1. XM_006251775.1.
UniGeneiRn.86175.

Genome annotation databases

GeneIDi306203.
KEGGirno:306203.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY327408 mRNA. Translation: AAP92800.1.
BC098901 mRNA. Translation: AAH98901.1.
RefSeqiNP_877973.1. NM_182821.1.
XP_006251837.1. XM_006251775.1.
UniGeneiRn.86175.

3D structure databases

ProteinModelPortaliQ4FZZ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010763.

Chemistry

ChEMBLiCHEMBL2176805.

PTM databases

iPTMnetiQ4FZZ1.

Proteomic databases

PaxDbiQ4FZZ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi306203.
KEGGirno:306203.

Organism-specific databases

CTDi54899.
RGDi727819. Pxk.

Phylogenomic databases

eggNOGiENOG410IF7B. Eukaryota.
ENOG410Z20X. LUCA.
HOGENOMiHOG000230568.
HOVERGENiHBG061245.
InParanoidiQ4FZZ1.
KOiK17543.
OMAiLESICKF.
OrthoDBiEOG7FFMRQ.
PhylomeDBiQ4FZZ1.

Miscellaneous databases

PROiQ4FZZ1.

Gene expression databases

GenevisibleiQ4FZZ1. RN.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR001683. Phox.
IPR000719. Prot_kinase_dom.
IPR003124. WH2_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00787. PX. 1 hit.
PF02205. WH2. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50195. PX. 1 hit.
PS51082. WH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Shan Y.X., Yu L.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-DawleyImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiPXK_RAT
AccessioniPrimary (citable) accession number: Q4FZZ1
Secondary accession number(s): Q7TNZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: August 30, 2005
Last modified: July 6, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.