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Protein
Submitted name:

Protein Sirt6

Gene

Sirt6

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-5693607. Processing of DNA double-strand break ends.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Sirt6Imported
Submitted name:
Sirtuin 6 (Silent mating type information regulation 2, homolog) 6 (S. cerevisiae)Imported
Submitted name:
Sirtuin 6 (Silent mating type information regulation 2, homolog) 6 (S. cerevisiae), isoform CRA_aImported
Gene namesi
Name:Sirt6Imported
ORF Names:rCG_29316Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1305216. Sirt6.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • nuclear telomeric heterochromatin Source: Ensembl
  • nucleoplasm Source: Ensembl
  • nucleus Source: RGD
Complete GO annotation...

PTM / Processingi

PTM databases

PhosphoSiteiQ4FZY2.

Expressioni

Gene expression databases

BgeeiENSRNOG00000006393.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008758.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 274240Deacetylase sirtuin-typeInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG1905. Eukaryota.
COG0846. LUCA.
GeneTreeiENSGT00530000063706.
HOGENOMiHOG000231240.
HOVERGENiHBG060028.
KOiK11416.
OMAiNVLDWEH.
OrthoDBiEOG091G0FOW.
TreeFamiTF106184.

Family and domain databases

Gene3Di3.40.50.1220. 2 hits.
InterProiIPR029035. DHS-like_NAD/FAD-binding_dom.
IPR003000. Sirtuin.
IPR026590. Ssirtuin_cat_dom.
[Graphical view]
PANTHERiPTHR11085. PTHR11085. 1 hit.
PfamiPF02146. SIR2. 2 hits.
[Graphical view]
SUPFAMiSSF52467. SSF52467. 1 hit.
PROSITEiPS50305. SIRTUIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4FZY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVNYAAGLS PYADKGKCGL PEIFDPPEEL ECKVWELARL MWQSSTVVFH
60 70 80 90 100
TGAGISTASG IPDFRGPHGV WTMEERGLAP KFDITFENAR PSKTHMALVQ
110 120 130 140 150
LERMGFLSFL VSQNVDGLHV RSGFPRDKLA ELHGNMFVEE CPKCKTQYVR
160 170 180 190 200
DTVVGTMGLK ATGRLCTVAK ARGLRACRGE LRDTILDWED ALPDRDLTLA
210 220 230 240 250
DEASRTADLS VTLGTSLQIR PSGNLPLATK RRGGRLVIVN LQPTKHDRQA
260 270 280 290 300
DLCIHGYVDE VMCKLMKHLG LEIPTWDGPR VLEKALPPLP RPVAPKAEPP
310 320 330
VHLNGSYKPK PDSPVPHRPP KRVKTEAAAS
Length:330
Mass (Da):36,365
Last modified:August 30, 2005 - v1
Checksum:iEFB8591B5DA416A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07055840 Genomic DNA. No translation available.
BC098923 mRNA. Translation: AAH98923.1.
CH474029 Genomic DNA. Translation: EDL89132.1.
CH474029 Genomic DNA. Translation: EDL89133.1.
RefSeqiNP_001026819.1. NM_001031649.1.
UniGeneiRn.8108.

Genome annotation databases

EnsembliENSRNOT00000008758; ENSRNOP00000008758; ENSRNOG00000006393.
GeneIDi299638.
KEGGirno:299638.
UCSCiRGD:1305216. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07055840 Genomic DNA. No translation available.
BC098923 mRNA. Translation: AAH98923.1.
CH474029 Genomic DNA. Translation: EDL89132.1.
CH474029 Genomic DNA. Translation: EDL89133.1.
RefSeqiNP_001026819.1. NM_001031649.1.
UniGeneiRn.8108.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008758.

PTM databases

PhosphoSiteiQ4FZY2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000008758; ENSRNOP00000008758; ENSRNOG00000006393.
GeneIDi299638.
KEGGirno:299638.
UCSCiRGD:1305216. rat.

Organism-specific databases

CTDi51548.
RGDi1305216. Sirt6.

Phylogenomic databases

eggNOGiKOG1905. Eukaryota.
COG0846. LUCA.
GeneTreeiENSGT00530000063706.
HOGENOMiHOG000231240.
HOVERGENiHBG060028.
KOiK11416.
OMAiNVLDWEH.
OrthoDBiEOG091G0FOW.
TreeFamiTF106184.

Enzyme and pathway databases

ReactomeiR-RNO-5693607. Processing of DNA double-strand break ends.

Gene expression databases

BgeeiENSRNOG00000006393.

Family and domain databases

Gene3Di3.40.50.1220. 2 hits.
InterProiIPR029035. DHS-like_NAD/FAD-binding_dom.
IPR003000. Sirtuin.
IPR026590. Ssirtuin_cat_dom.
[Graphical view]
PANTHERiPTHR11085. PTHR11085. 1 hit.
PfamiPF02146. SIR2. 2 hits.
[Graphical view]
SUPFAMiSSF52467. SSF52467. 1 hit.
PROSITEiPS50305. SIRTUIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ4FZY2_RAT
AccessioniPrimary (citable) accession number: Q4FZY2
Entry historyi
Integrated into UniProtKB/TrEMBL: August 30, 2005
Last sequence update: August 30, 2005
Last modified: September 7, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.