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Protein

EF-hand domain-containing protein D2

Gene

Efhd2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi104 – 1151PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi140 – 1512PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
EF-hand domain-containing protein D2
Alternative name(s):
Swiprosin-1
Gene namesi
Name:Efhd2
Synonyms:Sws1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1307585 Efhd2

Subcellular locationi

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002875802 – 239EF-hand domain-containing protein D2Add BLAST238

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei11PhosphoserineBy similarity1
Modified residuei73PhosphoserineCombined sources1
Modified residuei75PhosphoserineBy similarity1
Modified residuei82PhosphotyrosineBy similarity1
Modified residuei232N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ4FZY0
PRIDEiQ4FZY0

PTM databases

iPTMnetiQ4FZY0
PhosphoSitePlusiQ4FZY0

Expressioni

Gene expression databases

BgeeiENSRNOG00000013783
GenevisibleiQ4FZY0 RN

Interactioni

Subunit structurei

Interacts with CASP9; with inactive form.By similarity

Protein-protein interaction databases

BioGridi255962, 1 interactor
IntActiQ4FZY0, 2 interactors
STRINGi10116.ENSRNOP00000018864

Structurei

3D structure databases

ProteinModelPortaliQ4FZY0
SMRiQ4FZY0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini91 – 126EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini127 – 162EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0041 Eukaryota
ENOG4111JG9 LUCA
GeneTreeiENSGT00390000012058
HOGENOMiHOG000007978
HOVERGENiHBG051446
InParanoidiQ4FZY0
OMAiQYDAGKD
OrthoDBiEOG091G106K
PhylomeDBiQ4FZY0
TreeFamiTF320736

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4FZY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATDELASKL SRRLQMEDEG GEATEQPGLN GAAAAAAEAP DETAQALGSA
60 70 80 90 100
DDELSAKLLR RADLNQGIGE PQSPSRRVFN PYTEFKEFSR KQIKDMEKMF
110 120 130 140 150
KQYDAGKDGF IDLMELKLMM EKLGAPQTHL GLKSMIQEVD EDFDSKLSFR
160 170 180 190 200
EFLLIFRKAA AGELQEDSGL HVLARLSEID VSTEGVKGAK NFFEAKVQAI
210 220 230
NVSSRFEEEI KAEQEERKKQ AEEVKQRKAA FKELQSTFK
Length:239
Mass (Da):26,759
Last modified:August 30, 2005 - v1
Checksum:iBDA6F71C95D77ABB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098936 mRNA Translation: AAH98936.1
RefSeqiNP_001026818.1, NM_001031648.1
UniGeneiRn.92713

Genome annotation databases

EnsembliENSRNOT00000018864; ENSRNOP00000018864; ENSRNOG00000013783
GeneIDi298609
KEGGirno:298609
UCSCiRGD:1307585 rat

Similar proteinsi

Entry informationi

Entry nameiEFHD2_RAT
AccessioniPrimary (citable) accession number: Q4FZY0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: August 30, 2005
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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