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Protein

EF-hand domain-containing protein D2

Gene

Efhd2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi104 – 115121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi140 – 151122PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
EF-hand domain-containing protein D2
Alternative name(s):
Swiprosin-1
Gene namesi
Name:Efhd2
Synonyms:Sws1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1307585. Efhd2.

Subcellular locationi

  • Membrane raft By similarity

  • Note: In a mouse immature B-cell line WEHI-231.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 239238EF-hand domain-containing protein D2PRO_0000287580Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei11 – 111PhosphoserineBy similarity
Modified residuei73 – 731PhosphoserineCombined sources
Modified residuei75 – 751PhosphoserineBy similarity
Modified residuei82 – 821PhosphotyrosineBy similarity
Modified residuei232 – 2321N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ4FZY0.
PRIDEiQ4FZY0.

PTM databases

iPTMnetiQ4FZY0.
PhosphoSiteiQ4FZY0.

Expressioni

Gene expression databases

GenevisibleiQ4FZY0. RN.

Interactioni

Subunit structurei

Interacts with CASP9; with inactive form.By similarity

Protein-protein interaction databases

BioGridi255962. 1 interaction.
STRINGi10116.ENSRNOP00000018864.

Structurei

3D structure databases

ProteinModelPortaliQ4FZY0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini91 – 12636EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini127 – 16236EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0041. Eukaryota.
ENOG4111JG9. LUCA.
GeneTreeiENSGT00390000012058.
HOGENOMiHOG000007978.
HOVERGENiHBG051446.
InParanoidiQ4FZY0.
OMAiKYDVGND.
OrthoDBiEOG7H1JNV.
PhylomeDBiQ4FZY0.
TreeFamiTF320736.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4FZY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATDELASKL SRRLQMEDEG GEATEQPGLN GAAAAAAEAP DETAQALGSA
60 70 80 90 100
DDELSAKLLR RADLNQGIGE PQSPSRRVFN PYTEFKEFSR KQIKDMEKMF
110 120 130 140 150
KQYDAGKDGF IDLMELKLMM EKLGAPQTHL GLKSMIQEVD EDFDSKLSFR
160 170 180 190 200
EFLLIFRKAA AGELQEDSGL HVLARLSEID VSTEGVKGAK NFFEAKVQAI
210 220 230
NVSSRFEEEI KAEQEERKKQ AEEVKQRKAA FKELQSTFK
Length:239
Mass (Da):26,759
Last modified:August 30, 2005 - v1
Checksum:iBDA6F71C95D77ABB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098936 mRNA. Translation: AAH98936.1.
RefSeqiNP_001026818.1. NM_001031648.1.
UniGeneiRn.92713.

Genome annotation databases

EnsembliENSRNOT00000018864; ENSRNOP00000018864; ENSRNOG00000013783.
GeneIDi298609.
KEGGirno:298609.
UCSCiRGD:1307585. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098936 mRNA. Translation: AAH98936.1.
RefSeqiNP_001026818.1. NM_001031648.1.
UniGeneiRn.92713.

3D structure databases

ProteinModelPortaliQ4FZY0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi255962. 1 interaction.
STRINGi10116.ENSRNOP00000018864.

PTM databases

iPTMnetiQ4FZY0.
PhosphoSiteiQ4FZY0.

Proteomic databases

PaxDbiQ4FZY0.
PRIDEiQ4FZY0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018864; ENSRNOP00000018864; ENSRNOG00000013783.
GeneIDi298609.
KEGGirno:298609.
UCSCiRGD:1307585. rat.

Organism-specific databases

CTDi79180.
RGDi1307585. Efhd2.

Phylogenomic databases

eggNOGiKOG0041. Eukaryota.
ENOG4111JG9. LUCA.
GeneTreeiENSGT00390000012058.
HOGENOMiHOG000007978.
HOVERGENiHBG051446.
InParanoidiQ4FZY0.
OMAiKYDVGND.
OrthoDBiEOG7H1JNV.
PhylomeDBiQ4FZY0.
TreeFamiTF320736.

Miscellaneous databases

PROiQ4FZY0.

Gene expression databases

GenevisibleiQ4FZY0. RN.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  2. Lubec G., Chen W.-Q.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 123-133; 151-157; 159-187; 197-217 AND 233-239, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Hippocampus.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiEFHD2_RAT
AccessioniPrimary (citable) accession number: Q4FZY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: August 30, 2005
Last modified: June 8, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.