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Q4FZX7

- SRPRB_RAT

UniProt

Q4FZX7 - SRPRB_RAT

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Protein
Signal recognition particle receptor subunit beta
Gene
Srprb
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei118 – 1181GTP; via amide nitrogen By similarity
Binding sitei246 – 2461GTP; via amide nitrogen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi69 – 779GTP By similarity
Nucleotide bindingi90 – 934GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. ubiquitin protein ligase binding Source: RGD

GO - Biological processi

  1. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_196255. Transferrin endocytosis and recycling.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal recognition particle receptor subunit beta
Short name:
SR-beta
Gene namesi
Name:Srprb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi1304698. Srprb.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei35 – 5521Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. basal plasma membrane Source: Ensembl
  3. coated pit Source: Ensembl
  4. cytoplasmic microtubule Source: UniProtKB
  5. early endosome Source: Ensembl
  6. endocytic vesicle Source: Ensembl
  7. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  8. integral component of membrane Source: UniProtKB-KW
  9. late endosome Source: Ensembl
  10. mitochondrion Source: Ensembl
  11. perinuclear region of cytoplasm Source: Ensembl
  12. recycling endosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Signal recognition particle receptor subunit beta
PRO_0000331245Add
BLAST

Proteomic databases

PaxDbiQ4FZX7.
PRIDEiQ4FZX7.

Expressioni

Gene expression databases

ArrayExpressiQ4FZX7.
GenevestigatoriQ4FZX7.

Interactioni

Subunit structurei

Heterodimer with SRPR By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ4FZX7.
SMRiQ4FZX7. Positions 63-269.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2229.
HOVERGENiHBG054206.
InParanoidiQ4FZX7.
KOiK12272.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR024156. Small_GTPase_ARF.
IPR019009. SRP_receptor_beta_su.
[Graphical view]
PfamiPF09439. SRPRB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4FZX7-1 [UniParc]FASTAAdd to Basket

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MASANTRRVG DGAGGAFQPY LDSLRQELQQ RDPTLLSVAV AVLAVLLTLV    50
FWKFIWSRKS SQRAVLFVGL CDSGKTLLFV RLLTGQYRDT QTSITDSSAI 100
YKVNNNRGNS LTLIDLPGHE SLRLQFLDRF KSSARAVVFV VDSATFQREV 150
KDVAEFLYQV LIDSMALKNT PAFLVACNKQ DIAMAKSAKL IQQQLEKELN 200
TLRVTRSAAP STLDSSSTAP AQLGKKGKEF EFSQLPLKVE FLECSAKGGR 250
GDAGSADVQD LEKWLAKIA 269
Length:269
Mass (Da):29,569
Last modified:August 30, 2005 - v1
Checksum:iDA63194232A47386
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC098951 mRNA. Translation: AAH98951.1.
RefSeqiNP_001013270.1. NM_001013252.1.
UniGeneiRn.138078.

Genome annotation databases

GeneIDi300965.
KEGGirno:300965.
UCSCiRGD:1304698. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC098951 mRNA. Translation: AAH98951.1 .
RefSeqi NP_001013270.1. NM_001013252.1.
UniGenei Rn.138078.

3D structure databases

ProteinModelPortali Q4FZX7.
SMRi Q4FZX7. Positions 63-269.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q4FZX7.
PRIDEi Q4FZX7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 300965.
KEGGi rno:300965.
UCSCi RGD:1304698. rat.

Organism-specific databases

CTDi 58477.
RGDi 1304698. Srprb.

Phylogenomic databases

eggNOGi COG2229.
HOVERGENi HBG054206.
InParanoidi Q4FZX7.
KOi K12272.

Enzyme and pathway databases

Reactomei REACT_196255. Transferrin endocytosis and recycling.

Miscellaneous databases

NextBioi 647800.
PROi Q4FZX7.

Gene expression databases

ArrayExpressi Q4FZX7.
Genevestigatori Q4FZX7.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR024156. Small_GTPase_ARF.
IPR019009. SRP_receptor_beta_su.
[Graphical view ]
Pfami PF09439. SRPRB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiSRPRB_RAT
AccessioniPrimary (citable) accession number: Q4FZX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: August 30, 2005
Last modified: September 3, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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