Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Signal recognition particle receptor subunit beta

Gene

Srprb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei118 – 1181GTP; via amide nitrogenBy similarity
Binding sitei246 – 2461GTP; via amide nitrogenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi69 – 779GTPBy similarity
Nucleotide bindingi90 – 934GTPBy similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. ubiquitin protein ligase binding Source: RGD

GO - Biological processi

  1. retina homeostasis Source: Ensembl
  2. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_280231. Transferrin endocytosis and recycling.
REACT_288006. Platelet degranulation.
REACT_313297. Iron uptake and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal recognition particle receptor subunit beta
Short name:
SR-beta
Gene namesi
Name:Srprb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1304698. Srprb.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei35 – 5521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. basal plasma membrane Source: Ensembl
  3. blood microparticle Source: Ensembl
  4. cell surface Source: Ensembl
  5. coated pit Source: Ensembl
  6. cytoplasmic microtubule Source: UniProtKB
  7. early endosome Source: Ensembl
  8. endocytic vesicle Source: Ensembl
  9. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  10. extracellular vesicular exosome Source: Ensembl
  11. integral component of membrane Source: UniProtKB-KW
  12. late endosome Source: Ensembl
  13. perinuclear region of cytoplasm Source: Ensembl
  14. recycling endosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Signal recognition particle receptor subunit betaPRO_0000331245Add
BLAST

Proteomic databases

PaxDbiQ4FZX7.
PRIDEiQ4FZX7.

Expressioni

Gene expression databases

ExpressionAtlasiQ4FZX7. baseline and differential.
GenevestigatoriQ4FZX7.

Interactioni

Subunit structurei

Heterodimer with SRPR.By similarity

Protein-protein interaction databases

BioGridi256772. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ4FZX7.
SMRiQ4FZX7. Positions 63-269.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SRP receptor beta subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2229.
HOVERGENiHBG054206.
InParanoidiQ4FZX7.
KOiK12272.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR024156. Small_GTPase_ARF.
IPR019009. SRP_receptor_beta_su.
[Graphical view]
PfamiPF09439. SRPRB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4FZX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASANTRRVG DGAGGAFQPY LDSLRQELQQ RDPTLLSVAV AVLAVLLTLV
60 70 80 90 100
FWKFIWSRKS SQRAVLFVGL CDSGKTLLFV RLLTGQYRDT QTSITDSSAI
110 120 130 140 150
YKVNNNRGNS LTLIDLPGHE SLRLQFLDRF KSSARAVVFV VDSATFQREV
160 170 180 190 200
KDVAEFLYQV LIDSMALKNT PAFLVACNKQ DIAMAKSAKL IQQQLEKELN
210 220 230 240 250
TLRVTRSAAP STLDSSSTAP AQLGKKGKEF EFSQLPLKVE FLECSAKGGR
260
GDAGSADVQD LEKWLAKIA
Length:269
Mass (Da):29,569
Last modified:August 30, 2005 - v1
Checksum:iDA63194232A47386
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098951 mRNA. Translation: AAH98951.1.
RefSeqiNP_001013270.1. NM_001013252.1.
UniGeneiRn.138078.

Genome annotation databases

GeneIDi300965.
KEGGirno:300965.
UCSCiRGD:1304698. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098951 mRNA. Translation: AAH98951.1.
RefSeqiNP_001013270.1. NM_001013252.1.
UniGeneiRn.138078.

3D structure databases

ProteinModelPortaliQ4FZX7.
SMRiQ4FZX7. Positions 63-269.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi256772. 1 interaction.

Proteomic databases

PaxDbiQ4FZX7.
PRIDEiQ4FZX7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi300965.
KEGGirno:300965.
UCSCiRGD:1304698. rat.

Organism-specific databases

CTDi58477.
RGDi1304698. Srprb.

Phylogenomic databases

eggNOGiCOG2229.
HOVERGENiHBG054206.
InParanoidiQ4FZX7.
KOiK12272.

Enzyme and pathway databases

ReactomeiREACT_280231. Transferrin endocytosis and recycling.
REACT_288006. Platelet degranulation.
REACT_313297. Iron uptake and transport.

Miscellaneous databases

NextBioi647800.
PROiQ4FZX7.

Gene expression databases

ExpressionAtlasiQ4FZX7. baseline and differential.
GenevestigatoriQ4FZX7.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR024156. Small_GTPase_ARF.
IPR019009. SRP_receptor_beta_su.
[Graphical view]
PfamiPF09439. SRPRB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiSRPRB_RAT
AccessioniPrimary (citable) accession number: Q4FZX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: August 30, 2005
Last modified: April 1, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.