Q4FZX7 (SRPRB_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Signal recognition particle receptor subunit beta
Short name=SR-beta

Gene names

Name:

Srprb

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	269 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR By similarity.
Subunit structure	Heterodimer with SRPR By similarity.
Subcellular location	Endoplasmic reticulum membrane; Single-pass membrane protein By similarity.
Sequence similarities	Belongs to the SRP receptor beta subunit family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane Transmembrane helix
Ligand	GTP-binding Nucleotide-binding
Molecular function	Receptor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	apical plasma membrane Inferred from electronic annotation. Source: Compara basal plasma membrane Inferred from electronic annotation. Source: Compara coated pit Inferred from electronic annotation. Source: Compara cytoplasmic microtubule Inferred from sequence or structural similarity. Source: UniProtKB early endosome Inferred from electronic annotation. Source: Compara endocytic vesicle Inferred from electronic annotation. Source: Compara endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW late endosome Inferred from electronic annotation. Source: Compara mitochondrion Inferred from electronic annotation. Source: Compara perinuclear region of cytoplasm Inferred from electronic annotation. Source: Compara recycling endosome Inferred from electronic annotation. Source: Compara
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 269	269	Signal recognition particle receptor subunit beta		PRO_0000331245
Regions
	Transmembrane	35 – 55	21	Helical; Potential
	Nucleotide binding	69 – 77	9	GTP By similarity
	Nucleotide binding	90 – 93	4	GTP By similarity
Sites
	Binding site	118	1	GTP; via amide nitrogen By similarity
	Binding site	246	1	GTP; via amide nitrogen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4FZX7 [UniParc]. Last modified August 30, 2005. Version 1. Checksum: DA63194232A47386	FASTA	269	29,569
	10 20 30 40 50 60 MASANTRRVG DGAGGAFQPY LDSLRQELQQ RDPTLLSVAV AVLAVLLTLV FWKFIWSRKS 70 80 90 100 110 120 SQRAVLFVGL CDSGKTLLFV RLLTGQYRDT QTSITDSSAI YKVNNNRGNS LTLIDLPGHE 130 140 150 160 170 180 SLRLQFLDRF KSSARAVVFV VDSATFQREV KDVAEFLYQV LIDSMALKNT PAFLVACNKQ 190 200 210 220 230 240 DIAMAKSAKL IQQQLEKELN TLRVTRSAAP STLDSSSTAP AQLGKKGKEF EFSQLPLKVE 250 260 FLECSAKGGR GDAGSADVQD LEKWLAKIA

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC098951 mRNA. Translation: AAH98951.1.
IPI	IPI00557236.
RefSeq	NP_001013270.1. NM_001013252.1.
UniGene	Rn.138078.
3D structure databases
ProteinModelPortal	Q4FZX7.
SMR	Q4FZX7. Positions 63-269.
ModBase	Search...
Proteomic databases
PaxDb	Q4FZX7.
PRIDE	Q4FZX7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	300965.
KEGG	rno:300965.
UCSC	RGD:1304698. rat.
Organism-specific databases
CTD	58477.
RGD	1304698. Srprb.
Phylogenomic databases
eggNOG	COG2229.
HOVERGEN	HBG054206.
InParanoid	Q4FZX7.
KO	K12272.
OrthoDB	EOG4CRKZG.
Gene expression databases
ArrayExpress	Q4FZX7.
Genevestigator	Q4FZX7.
Family and domain databases
InterPro	IPR027417. P-loop_NTPase. IPR024156. Small_GTPase_ARF. IPR019009. SRP_receptor_beta_su. [Graphical view]
Pfam	PF09439. SRPRB. 1 hit. [Graphical view]
SUPFAM	SSF52540. SSF52540. 1 hit.
ProtoNet	Search...
Other
NextBio	647800.

Entry information

Entry name

SRPRB_RAT

Accession

Primary (citable) accession number: Q4FZX7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	August 30, 2005
Last modified:	May 29, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program