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Q4FZX7

- SRPRB_RAT

UniProt

Q4FZX7 - SRPRB_RAT

Protein

Signal recognition particle receptor subunit beta

Gene

Srprb

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (30 Aug 2005)
      Previous versions | rss
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    Functioni

    Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei118 – 1181GTP; via amide nitrogenBy similarity
    Binding sitei246 – 2461GTP; via amide nitrogenBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi69 – 779GTPBy similarity
    Nucleotide bindingi90 – 934GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW
    2. ubiquitin protein ligase binding Source: RGD

    GO - Biological processi

    1. small GTPase mediated signal transduction Source: InterPro

    Keywords - Molecular functioni

    Receptor

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_196255. Transferrin endocytosis and recycling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Signal recognition particle receptor subunit beta
    Short name:
    SR-beta
    Gene namesi
    Name:Srprb
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1304698. Srprb.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. basal plasma membrane Source: Ensembl
    3. coated pit Source: Ensembl
    4. cytoplasmic microtubule Source: UniProtKB
    5. early endosome Source: Ensembl
    6. endocytic vesicle Source: Ensembl
    7. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    8. integral component of membrane Source: UniProtKB-KW
    9. late endosome Source: Ensembl
    10. mitochondrion Source: Ensembl
    11. perinuclear region of cytoplasm Source: Ensembl
    12. recycling endosome Source: Ensembl

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 269269Signal recognition particle receptor subunit betaPRO_0000331245Add
    BLAST

    Proteomic databases

    PaxDbiQ4FZX7.
    PRIDEiQ4FZX7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ4FZX7.
    GenevestigatoriQ4FZX7.

    Interactioni

    Subunit structurei

    Heterodimer with SRPR.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ4FZX7.
    SMRiQ4FZX7. Positions 63-269.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei35 – 5521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SRP receptor beta subunit family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2229.
    HOVERGENiHBG054206.
    InParanoidiQ4FZX7.
    KOiK12272.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR024156. Small_GTPase_ARF.
    IPR019009. SRP_receptor_beta_su.
    [Graphical view]
    PfamiPF09439. SRPRB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q4FZX7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASANTRRVG DGAGGAFQPY LDSLRQELQQ RDPTLLSVAV AVLAVLLTLV    50
    FWKFIWSRKS SQRAVLFVGL CDSGKTLLFV RLLTGQYRDT QTSITDSSAI 100
    YKVNNNRGNS LTLIDLPGHE SLRLQFLDRF KSSARAVVFV VDSATFQREV 150
    KDVAEFLYQV LIDSMALKNT PAFLVACNKQ DIAMAKSAKL IQQQLEKELN 200
    TLRVTRSAAP STLDSSSTAP AQLGKKGKEF EFSQLPLKVE FLECSAKGGR 250
    GDAGSADVQD LEKWLAKIA 269
    Length:269
    Mass (Da):29,569
    Last modified:August 30, 2005 - v1
    Checksum:iDA63194232A47386
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC098951 mRNA. Translation: AAH98951.1.
    RefSeqiNP_001013270.1. NM_001013252.1.
    UniGeneiRn.138078.

    Genome annotation databases

    GeneIDi300965.
    KEGGirno:300965.
    UCSCiRGD:1304698. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC098951 mRNA. Translation: AAH98951.1 .
    RefSeqi NP_001013270.1. NM_001013252.1.
    UniGenei Rn.138078.

    3D structure databases

    ProteinModelPortali Q4FZX7.
    SMRi Q4FZX7. Positions 63-269.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q4FZX7.
    PRIDEi Q4FZX7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 300965.
    KEGGi rno:300965.
    UCSCi RGD:1304698. rat.

    Organism-specific databases

    CTDi 58477.
    RGDi 1304698. Srprb.

    Phylogenomic databases

    eggNOGi COG2229.
    HOVERGENi HBG054206.
    InParanoidi Q4FZX7.
    KOi K12272.

    Enzyme and pathway databases

    Reactomei REACT_196255. Transferrin endocytosis and recycling.

    Miscellaneous databases

    NextBioi 647800.
    PROi Q4FZX7.

    Gene expression databases

    ArrayExpressi Q4FZX7.
    Genevestigatori Q4FZX7.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR024156. Small_GTPase_ARF.
    IPR019009. SRP_receptor_beta_su.
    [Graphical view ]
    Pfami PF09439. SRPRB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiSRPRB_RAT
    AccessioniPrimary (citable) accession number: Q4FZX7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: August 30, 2005
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3