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Protein

Methionine-R-sulfoxide reductase B2, mitochondrial

Gene

Msrb2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance.By similarity

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin.By similarity
L-methionine + thioredoxin disulfide + H2O = L-methionine (R)-S-oxide + thioredoxin.By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi82ZincPROSITE-ProRule annotation1
Metal bindingi85ZincPROSITE-ProRule annotation1
Metal bindingi138ZincPROSITE-ProRule annotation1
Metal bindingi141ZincPROSITE-ProRule annotation1
Active sitei161NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-5676934 Protein repair

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine-R-sulfoxide reductase B2, mitochondrial (EC:1.8.4.12By similarity, EC:1.8.4.14By similarity)
Short name:
MsrB2
Gene namesi
Name:Msrb2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi1306026 Msrb2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 61MitochondrionSequence analysisAdd BLAST61
ChainiPRO_000032724462 – 174Methionine-R-sulfoxide reductase B2, mitochondrialAdd BLAST113

Proteomic databases

PaxDbiQ4FZX5
PRIDEiQ4FZX5

PTM databases

PhosphoSitePlusiQ4FZX5

Expressioni

Gene expression databases

BgeeiENSRNOG00000016873
GenevisibleiQ4FZX5 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022661

Structurei

3D structure databases

ProteinModelPortaliQ4FZX5
SMRiQ4FZX5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 172MsrBPROSITE-ProRule annotationAdd BLAST111

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0856 Eukaryota
COG0229 LUCA
GeneTreeiENSGT00510000046802
HOGENOMiHOG000243424
HOVERGENiHBG002192
InParanoidiQ4FZX5
KOiK07305
OMAiQYVVTRE
OrthoDBiEOG091G043K
PhylomeDBiQ4FZX5
TreeFamiTF329147

Family and domain databases

InterProiView protein in InterPro
IPR028427 Met_Sox_Rdtase
IPR002579 Met_Sox_Rdtase_MsrB
IPR011057 Mss4-like_sf
PANTHERiPTHR10173 PTHR10173, 1 hit
PfamiView protein in Pfam
PF01641 SelR, 1 hit
SUPFAMiSSF51316 SSF51316, 1 hit
TIGRFAMsiTIGR00357 TIGR00357, 1 hit
PROSITEiView protein in PROSITE
PS51790 MSRB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4FZX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARLLRALRG LPWLEAPGRA RGCAGSGRGD TGSLIKSKLS LSKADWQKKL
60 70 80 90 100
TPEQFYVTRE KGTEAPFSGM YLKNKETGMY HCVCCDSPLF SSEKKYCSGT
110 120 130 140 150
GWPSFSEAHG TKGSDESHTG ILRRLDTSLG CPRMEVVCKQ CEAHLGHVFP
160 170
DGPDPTGQRF CINSVALKFK PSKP
Length:174
Mass (Da):19,073
Last modified:August 30, 2005 - v1
Checksum:iAE44A32C8AD71A6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098953 mRNA Translation: AAH98953.1
RefSeqiNP_001026830.1, NM_001031660.1
UniGeneiRn.23802

Genome annotation databases

EnsembliENSRNOT00000022661; ENSRNOP00000022661; ENSRNOG00000016873
GeneIDi361286
KEGGirno:361286
UCSCiRGD:1306026 rat

Similar proteinsi

Entry informationi

Entry nameiMSRB2_RAT
AccessioniPrimary (citable) accession number: Q4FZX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: August 30, 2005
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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