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Protein

Methionine-R-sulfoxide reductase B2, mitochondrial

Gene

Msrb2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance (By similarity).By similarity

Catalytic activityi

L-methionine + oxidized thioredoxin = L-methionine R-oxide + reduced thioredoxin.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi82ZincPROSITE-ProRule annotation1
Metal bindingi85ZincPROSITE-ProRule annotation1
Metal bindingi138ZincPROSITE-ProRule annotation1
Metal bindingi141ZincPROSITE-ProRule annotation1
Active sitei161NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-5676934. Protein repair.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine-R-sulfoxide reductase B2, mitochondrial (EC:1.8.4.-)
Short name:
MsrB2
Gene namesi
Name:Msrb2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi1306026. Msrb2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 61MitochondrionSequence analysisAdd BLAST61
ChainiPRO_000032724462 – 174Methionine-R-sulfoxide reductase B2, mitochondrialAdd BLAST113

Proteomic databases

PaxDbiQ4FZX5.
PRIDEiQ4FZX5.

PTM databases

PhosphoSitePlusiQ4FZX5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000016873.
GenevisibleiQ4FZX5. RN.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022661.

Structurei

3D structure databases

ProteinModelPortaliQ4FZX5.
SMRiQ4FZX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 172MsrBPROSITE-ProRule annotationAdd BLAST111

Sequence similaritiesi

Contains 1 MsrB (methionine-R-sulfoxide reductase) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0856. Eukaryota.
COG0229. LUCA.
GeneTreeiENSGT00510000046802.
HOGENOMiHOG000243424.
HOVERGENiHBG002192.
InParanoidiQ4FZX5.
KOiK07305.
OMAiHGTWERD.
OrthoDBiEOG091G043K.
PhylomeDBiQ4FZX5.
TreeFamiTF329147.

Family and domain databases

Gene3Di2.170.150.20. 1 hit.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002579. Met_Sox_Rdtase_MsrB.
IPR011057. Mss4-like.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01641. SelR. 1 hit.
[Graphical view]
SUPFAMiSSF51316. SSF51316. 1 hit.
TIGRFAMsiTIGR00357. TIGR00357. 1 hit.
PROSITEiPS51790. MSRB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4FZX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARLLRALRG LPWLEAPGRA RGCAGSGRGD TGSLIKSKLS LSKADWQKKL
60 70 80 90 100
TPEQFYVTRE KGTEAPFSGM YLKNKETGMY HCVCCDSPLF SSEKKYCSGT
110 120 130 140 150
GWPSFSEAHG TKGSDESHTG ILRRLDTSLG CPRMEVVCKQ CEAHLGHVFP
160 170
DGPDPTGQRF CINSVALKFK PSKP
Length:174
Mass (Da):19,073
Last modified:August 30, 2005 - v1
Checksum:iAE44A32C8AD71A6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098953 mRNA. Translation: AAH98953.1.
RefSeqiNP_001026830.1. NM_001031660.1.
UniGeneiRn.23802.

Genome annotation databases

EnsembliENSRNOT00000022661; ENSRNOP00000022661; ENSRNOG00000016873.
GeneIDi361286.
KEGGirno:361286.
UCSCiRGD:1306026. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098953 mRNA. Translation: AAH98953.1.
RefSeqiNP_001026830.1. NM_001031660.1.
UniGeneiRn.23802.

3D structure databases

ProteinModelPortaliQ4FZX5.
SMRiQ4FZX5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022661.

PTM databases

PhosphoSitePlusiQ4FZX5.

Proteomic databases

PaxDbiQ4FZX5.
PRIDEiQ4FZX5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022661; ENSRNOP00000022661; ENSRNOG00000016873.
GeneIDi361286.
KEGGirno:361286.
UCSCiRGD:1306026. rat.

Organism-specific databases

CTDi22921.
RGDi1306026. Msrb2.

Phylogenomic databases

eggNOGiKOG0856. Eukaryota.
COG0229. LUCA.
GeneTreeiENSGT00510000046802.
HOGENOMiHOG000243424.
HOVERGENiHBG002192.
InParanoidiQ4FZX5.
KOiK07305.
OMAiHGTWERD.
OrthoDBiEOG091G043K.
PhylomeDBiQ4FZX5.
TreeFamiTF329147.

Enzyme and pathway databases

ReactomeiR-RNO-5676934. Protein repair.

Miscellaneous databases

PROiQ4FZX5.

Gene expression databases

BgeeiENSRNOG00000016873.
GenevisibleiQ4FZX5. RN.

Family and domain databases

Gene3Di2.170.150.20. 1 hit.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002579. Met_Sox_Rdtase_MsrB.
IPR011057. Mss4-like.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01641. SelR. 1 hit.
[Graphical view]
SUPFAMiSSF51316. SSF51316. 1 hit.
TIGRFAMsiTIGR00357. TIGR00357. 1 hit.
PROSITEiPS51790. MSRB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMSRB2_RAT
AccessioniPrimary (citable) accession number: Q4FZX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: August 30, 2005
Last modified: November 2, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.