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Protein
Submitted name:

Protein Serinc2

Gene

Serinc2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • L-serine transmembrane transporter activity Source: HGNC

GO - Biological processi

  • L-serine transport Source: HGNC
  • phosphatidylserine metabolic process Source: HGNC
  • positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity Source: BHF-UCL
  • positive regulation of serine C-palmitoyltransferase activity Source: BHF-UCL
  • sphingolipid metabolic process Source: HGNC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Serinc2Imported
Submitted name:
Serine incorporator 2Imported
Gene namesi
Name:Serinc2Imported
ORF Names:rCG_31282Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1311396. Serinc2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei36 – 5722HelicalSequence analysisAdd
BLAST
Transmembranei100 – 12122HelicalSequence analysisAdd
BLAST
Transmembranei133 – 15119HelicalSequence analysisAdd
BLAST
Transmembranei158 – 17922HelicalSequence analysisAdd
BLAST
Transmembranei199 – 22628HelicalSequence analysisAdd
BLAST
Transmembranei238 – 25619HelicalSequence analysisAdd
BLAST
Transmembranei268 – 28619HelicalSequence analysisAdd
BLAST
Transmembranei315 – 33723HelicalSequence analysisAdd
BLAST
Transmembranei381 – 39919HelicalSequence analysisAdd
BLAST
Transmembranei420 – 44425HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: HGNC
  • extracellular exosome Source: Ensembl
  • integral component of membrane Source: GO_Central
  • plasma membrane Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 450431Sequence analysisPRO_5005932681Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017577.

Family & Domainsi

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410XP7K. LUCA.
KOG2592. Eukaryota.
GeneTreeiENSGT00550000074522.
HOGENOMiHOG000165463.
HOVERGENiHBG025699.
OMAiPEQKCNP.
OrthoDBiEOG7TXKGQ.

Family and domain databases

InterProiIPR029554. SERINC2.
IPR005016. TDE1/TMS.
[Graphical view]
PANTHERiPTHR10383. PTHR10383. 1 hit.
PTHR10383:SF22. PTHR10383:SF22. 1 hit.
PfamiPF03348. Serinc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4FZV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGACLGACSL LSCASCLCGS APCILCSCCP STRNSTVSRL LFTGFLFLGV
60 70 80 90 100
LVSIIMLSPG VESQLYKLPW VCEDRAQQPV VLQGPLDCGS LLGFRAVYRM
110 120 130 140 150
CFATAAFFFL FMMLMICVRS SRDPRAAIQN GFWFFKFLIL VGITVGAFYI
160 170 180 190 200
PDGSFPKIWF YFGVVGSFLF ILIQLILFID FAHSWNQRWL CKAEECDSPV
210 220 230 240 250
WYAGLFFFTF LFYLLSIAAV ALMFVYYTES GACHEGKVFI GLNLTFCVCV
260 270 280 290 300
SIIAVLPKVQ SAQPNSGLLQ ASVVTLYTMF VTWSALSNVP DQKCNPHLPT
310 320 330 340 350
KNGTGQVNLE DYSTVWWDAP SIVGLVIFIL CTFFISLRSS DHRQVNSLMQ
360 370 380 390 400
TEECPAEMVQ QQQVAVGDGR TYDNEQDGVT YSYSFFHFCL VLASLHVMMT
410 420 430 440 450
LTNWYSPGET RKMISTWTSV WVKICASWAG LFLYLWTLVA PLLLPNRDFS
Length:450
Mass (Da):50,387
Last modified:August 30, 2005 - v1
Checksum:i66001E14CA5D48BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07050017 Genomic DNA. No translation available.
BC099093 mRNA. Translation: AAH99093.1.
DQ103709 mRNA. Translation: AAZ80296.1.
CH473968 Genomic DNA. Translation: EDL80589.1.
RefSeqiNP_001026826.1. NM_001031656.1.
UniGeneiRn.144273.

Genome annotation databases

EnsembliENSRNOT00000017577; ENSRNOP00000017577; ENSRNOG00000012989.
GeneIDi313057.
KEGGirno:313057.
UCSCiRGD:1311396. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07050017 Genomic DNA. No translation available.
BC099093 mRNA. Translation: AAH99093.1.
DQ103709 mRNA. Translation: AAZ80296.1.
CH473968 Genomic DNA. Translation: EDL80589.1.
RefSeqiNP_001026826.1. NM_001031656.1.
UniGeneiRn.144273.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017577.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000017577; ENSRNOP00000017577; ENSRNOG00000012989.
GeneIDi313057.
KEGGirno:313057.
UCSCiRGD:1311396. rat.

Organism-specific databases

CTDi347735.
RGDi1311396. Serinc2.

Phylogenomic databases

eggNOGiENOG410XP7K. LUCA.
KOG2592. Eukaryota.
GeneTreeiENSGT00550000074522.
HOGENOMiHOG000165463.
HOVERGENiHBG025699.
OMAiPEQKCNP.
OrthoDBiEOG7TXKGQ.

Miscellaneous databases

NextBioi665569.

Family and domain databases

InterProiIPR029554. SERINC2.
IPR005016. TDE1/TMS.
[Graphical view]
PANTHERiPTHR10383. PTHR10383. 1 hit.
PTHR10383:SF22. PTHR10383:SF22. 1 hit.
PfamiPF03348. Serinc. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PlacentaImported.
  2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. "Serinc, an activity-regulated protein family, incorporates serine into membrane lipid synthesis."
    Inuzuka M., Hayakawa M., Ingi T.
    J. Biol. Chem. 280:35776-35783(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.
    Tissue: BrainImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  6. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiQ4FZV1_RAT
AccessioniPrimary (citable) accession number: Q4FZV1
Entry historyi
Integrated into UniProtKB/TrEMBL: August 30, 2005
Last sequence update: August 30, 2005
Last modified: January 20, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.