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Q4FZV1

- Q4FZV1_RAT

UniProt

Q4FZV1 - Q4FZV1_RAT

Protein
Submitted name:

Protein Serinc2

Gene

Serinc2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (30 Aug 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. L-serine transmembrane transporter activity Source: HGNC

    GO - Biological processi

    1. L-serine transport Source: HGNC
    2. phosphatidylserine metabolic process Source: HGNC
    3. positive regulation of transferase activity Source: HGNC
    4. sphingolipid metabolic process Source: HGNC

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Protein Serinc2Imported
    Submitted name:
    Serine incorporator 2Imported
    Gene namesi
    Name:Serinc2Imported
    ORF Names:rCG_31282Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 5

    Organism-specific databases

    RGDi1311396. Serinc2.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: HGNC
    2. plasma membrane Source: HGNC

    Expressioni

    Gene expression databases

    GenevestigatoriQ4FZV1.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000060952.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG308011.
    GeneTreeiENSGT00550000074522.
    HOGENOMiHOG000165463.
    HOVERGENiHBG025699.
    InParanoidiQ4FZV1.
    OMAiKCNPHLP.
    OrthoDBiEOG7TXKGQ.

    Family and domain databases

    InterProiIPR029554. SERINC2.
    IPR005016. TDE1/TMS.
    [Graphical view]
    PANTHERiPTHR10383. PTHR10383. 1 hit.
    PTHR10383:SF22. PTHR10383:SF22. 1 hit.
    PfamiPF03348. Serinc. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4FZV1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGACLGACSL LSCASCLCGS APCILCSCCP STRNSTVSRL LFTGFLFLGV    50
    LVSIIMLSPG VESQLYKLPW VCEDRAQQPV VLQGPLDCGS LLGFRAVYRM 100
    CFATAAFFFL FMMLMICVRS SRDPRAAIQN GFWFFKFLIL VGITVGAFYI 150
    PDGSFPKIWF YFGVVGSFLF ILIQLILFID FAHSWNQRWL CKAEECDSPV 200
    WYAGLFFFTF LFYLLSIAAV ALMFVYYTES GACHEGKVFI GLNLTFCVCV 250
    SIIAVLPKVQ SAQPNSGLLQ ASVVTLYTMF VTWSALSNVP DQKCNPHLPT 300
    KNGTGQVNLE DYSTVWWDAP SIVGLVIFIL CTFFISLRSS DHRQVNSLMQ 350
    TEECPAEMVQ QQQVAVGDGR TYDNEQDGVT YSYSFFHFCL VLASLHVMMT 400
    LTNWYSPGET RKMISTWTSV WVKICASWAG LFLYLWTLVA PLLLPNRDFS 450
    Length:450
    Mass (Da):50,387
    Last modified:August 30, 2005 - v1
    Checksum:i66001E14CA5D48BC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06040090 Genomic DNA. No translation available.
    BC099093 mRNA. Translation: AAH99093.1.
    DQ103709 mRNA. Translation: AAZ80296.1.
    CH473968 Genomic DNA. Translation: EDL80589.1.
    RefSeqiNP_001026826.1. NM_001031656.1.
    UniGeneiRn.144273.

    Genome annotation databases

    EnsembliENSRNOT00000017577; ENSRNOP00000017577; ENSRNOG00000012989.
    GeneIDi313057.
    KEGGirno:313057.
    UCSCiRGD:1311396. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06040090 Genomic DNA. No translation available.
    BC099093 mRNA. Translation: AAH99093.1 .
    DQ103709 mRNA. Translation: AAZ80296.1 .
    CH473968 Genomic DNA. Translation: EDL80589.1 .
    RefSeqi NP_001026826.1. NM_001031656.1.
    UniGenei Rn.144273.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000060952.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000017577 ; ENSRNOP00000017577 ; ENSRNOG00000012989 .
    GeneIDi 313057.
    KEGGi rno:313057.
    UCSCi RGD:1311396. rat.

    Organism-specific databases

    CTDi 347735.
    RGDi 1311396. Serinc2.

    Phylogenomic databases

    eggNOGi NOG308011.
    GeneTreei ENSGT00550000074522.
    HOGENOMi HOG000165463.
    HOVERGENi HBG025699.
    InParanoidi Q4FZV1.
    OMAi KCNPHLP.
    OrthoDBi EOG7TXKGQ.

    Miscellaneous databases

    NextBioi 665569.

    Gene expression databases

    Genevestigatori Q4FZV1.

    Family and domain databases

    InterProi IPR029554. SERINC2.
    IPR005016. TDE1/TMS.
    [Graphical view ]
    PANTHERi PTHR10383. PTHR10383. 1 hit.
    PTHR10383:SF22. PTHR10383:SF22. 1 hit.
    Pfami PF03348. Serinc. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: PlacentaImported.
    2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. "Serinc, an activity-regulated protein family, incorporates serine into membrane lipid synthesis."
      Inuzuka M., Hayakawa M., Ingi T.
      J. Biol. Chem. 280:35776-35783(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Sprague-DawleyImported.
      Tissue: BrainImported.
    5. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    6. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiQ4FZV1_RAT
    AccessioniPrimary (citable) accession number: Q4FZV1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 30, 2005
    Last sequence update: August 30, 2005
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3