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Protein
Submitted name:

Protein Serinc2

Gene

Serinc2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • L-serine transmembrane transporter activity Source: HGNC

GO - Biological processi

  • L-serine transport Source: HGNC
  • phosphatidylserine metabolic process Source: HGNC
  • positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity Source: BHF-UCL
  • positive regulation of serine C-palmitoyltransferase activity Source: BHF-UCL
  • sphingolipid metabolic process Source: HGNC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Serinc2Imported
Submitted name:
Serine incorporator 2Imported
Gene namesi
Name:Serinc2Imported
ORF Names:rCG_31282Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1311396. Serinc2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei36 – 57HelicalSequence analysisAdd BLAST22
Transmembranei100 – 121HelicalSequence analysisAdd BLAST22
Transmembranei133 – 151HelicalSequence analysisAdd BLAST19
Transmembranei158 – 179HelicalSequence analysisAdd BLAST22
Transmembranei199 – 226HelicalSequence analysisAdd BLAST28
Transmembranei238 – 256HelicalSequence analysisAdd BLAST19
Transmembranei268 – 286HelicalSequence analysisAdd BLAST19
Transmembranei315 – 337HelicalSequence analysisAdd BLAST23
Transmembranei381 – 399HelicalSequence analysisAdd BLAST19
Transmembranei420 – 444HelicalSequence analysisAdd BLAST25

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: HGNC
  • extracellular exosome Source: Ensembl
  • integral component of membrane Source: GO_Central
  • plasma membrane Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500878050420 – 450Sequence analysisAdd BLAST431

Expressioni

Gene expression databases

BgeeiENSRNOG00000012989.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017577.

Family & Domainsi

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2592. Eukaryota.
ENOG410XP7K. LUCA.
GeneTreeiENSGT00550000074522.
HOGENOMiHOG000165463.
HOVERGENiHBG025699.
OMAiPEQKCNP.
OrthoDBiEOG091G07WS.

Family and domain databases

InterProiIPR029554. SERINC2.
IPR005016. TDE1/TMS.
[Graphical view]
PANTHERiPTHR10383. PTHR10383. 1 hit.
PTHR10383:SF22. PTHR10383:SF22. 1 hit.
PfamiPF03348. Serinc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4FZV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGACLGACSL LSCASCLCGS APCILCSCCP STRNSTVSRL LFTGFLFLGV
60 70 80 90 100
LVSIIMLSPG VESQLYKLPW VCEDRAQQPV VLQGPLDCGS LLGFRAVYRM
110 120 130 140 150
CFATAAFFFL FMMLMICVRS SRDPRAAIQN GFWFFKFLIL VGITVGAFYI
160 170 180 190 200
PDGSFPKIWF YFGVVGSFLF ILIQLILFID FAHSWNQRWL CKAEECDSPV
210 220 230 240 250
WYAGLFFFTF LFYLLSIAAV ALMFVYYTES GACHEGKVFI GLNLTFCVCV
260 270 280 290 300
SIIAVLPKVQ SAQPNSGLLQ ASVVTLYTMF VTWSALSNVP DQKCNPHLPT
310 320 330 340 350
KNGTGQVNLE DYSTVWWDAP SIVGLVIFIL CTFFISLRSS DHRQVNSLMQ
360 370 380 390 400
TEECPAEMVQ QQQVAVGDGR TYDNEQDGVT YSYSFFHFCL VLASLHVMMT
410 420 430 440 450
LTNWYSPGET RKMISTWTSV WVKICASWAG LFLYLWTLVA PLLLPNRDFS
Length:450
Mass (Da):50,387
Last modified:August 30, 2005 - v1
Checksum:i66001E14CA5D48BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07050017 Genomic DNA. No translation available.
BC099093 mRNA. Translation: AAH99093.1.
DQ103709 mRNA. Translation: AAZ80296.1.
CH473968 Genomic DNA. Translation: EDL80589.1.
RefSeqiNP_001026826.1. NM_001031656.1.
UniGeneiRn.144273.

Genome annotation databases

EnsembliENSRNOT00000017577; ENSRNOP00000017577; ENSRNOG00000012989.
GeneIDi313057.
KEGGirno:313057.
UCSCiRGD:1311396. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07050017 Genomic DNA. No translation available.
BC099093 mRNA. Translation: AAH99093.1.
DQ103709 mRNA. Translation: AAZ80296.1.
CH473968 Genomic DNA. Translation: EDL80589.1.
RefSeqiNP_001026826.1. NM_001031656.1.
UniGeneiRn.144273.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017577.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000017577; ENSRNOP00000017577; ENSRNOG00000012989.
GeneIDi313057.
KEGGirno:313057.
UCSCiRGD:1311396. rat.

Organism-specific databases

CTDi347735.
RGDi1311396. Serinc2.

Phylogenomic databases

eggNOGiKOG2592. Eukaryota.
ENOG410XP7K. LUCA.
GeneTreeiENSGT00550000074522.
HOGENOMiHOG000165463.
HOVERGENiHBG025699.
OMAiPEQKCNP.
OrthoDBiEOG091G07WS.

Gene expression databases

BgeeiENSRNOG00000012989.

Family and domain databases

InterProiIPR029554. SERINC2.
IPR005016. TDE1/TMS.
[Graphical view]
PANTHERiPTHR10383. PTHR10383. 1 hit.
PTHR10383:SF22. PTHR10383:SF22. 1 hit.
PfamiPF03348. Serinc. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ4FZV1_RAT
AccessioniPrimary (citable) accession number: Q4FZV1
Entry historyi
Integrated into UniProtKB/TrEMBL: August 30, 2005
Last sequence update: August 30, 2005
Last modified: November 30, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.