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Protein

Solute carrier family 52, riboflavin transporter, member 3

Gene

Slc52a3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Riboflavin transporter. Riboflavin transport is Na+-independent but moderately pH-sensitive. Activity is strongly inhibited by riboflavin analogs, such as lumiflavin, flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), and to a lesser extent by amiloride.1 Publication

Kineticsi

  1. KM=0.21 µM for riboflavin1 Publication
  1. Vmax=11 pmol/min/mg enzyme1 Publication

GO - Molecular functioni

  • riboflavin transporter activity Source: UniProtKB

GO - Biological processi

  • riboflavin transport Source: UniProtKB
  • sensory perception of sound Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 52, riboflavin transporter, member 3
Alternative name(s):
Riboflavin transporter 2
Short name:
rRFT2
Gene namesi
Name:Slc52a3
Synonyms:Rft2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1304644. Slc52a3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721HelicalSequence analysisAdd
BLAST
Transmembranei38 – 5821HelicalSequence analysisAdd
BLAST
Transmembranei72 – 9221HelicalSequence analysisAdd
BLAST
Transmembranei106 – 12621HelicalSequence analysisAdd
BLAST
Transmembranei138 – 15821HelicalSequence analysisAdd
BLAST
Transmembranei215 – 23521HelicalSequence analysisAdd
BLAST
Transmembranei295 – 31521HelicalSequence analysisAdd
BLAST
Transmembranei330 – 35021HelicalSequence analysisAdd
BLAST
Transmembranei354 – 37421HelicalSequence analysisAdd
BLAST
Transmembranei391 – 41121HelicalSequence analysisAdd
BLAST
Transmembranei422 – 44221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 463463Solute carrier family 52, riboflavin transporter, member 3PRO_0000399792Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence analysis
Modified residuei245 – 2451PhosphoserineCombined sources
Modified residuei269 – 2691PhosphoserineCombined sources

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ4FZU9.

PTM databases

iPTMnetiQ4FZU9.

Expressioni

Tissue specificityi

Predominantly expressed in small intestine. Highly expressed in jejunum and ileum. Also expressed in testis and at lower level in lung, kidney, stomach and colon.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006828.

Family & Domainsi

Sequence similaritiesi

Belongs to the riboflavin transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4255. Eukaryota.
ENOG410YE1U. LUCA.
HOGENOMiHOG000247012.
HOVERGENiHBG051170.
InParanoidiQ4FZU9.
KOiK14620.
PhylomeDBiQ4FZU9.

Family and domain databases

InterProiIPR009357. Riboflavin_transptr.
[Graphical view]
PANTHERiPTHR12929. PTHR12929. 1 hit.
PfamiPF06237. DUF1011. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4FZU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFLTHLLVC VFGMGSWVAI NGLWVELPLL VTKLPEGWYL PSYLTVVIQL
60 70 80 90 100
ANTGPLLVTL MHRFRPGCLS EVPVIFLILC VGTTACILLA FLWSMTSWIQ
110 120 130 140 150
GRQHSVAFIV LTFFLALVDC TSSVTFLPFM SQLPTYYLTT FFIGEGLSGL
160 170 180 190 200
LPALVALVQG SGITTCVNVT ETPGTTLNPV TTMETSITQR TLSPSLTPLT
210 220 230 240 250
WHLESRYLAP RFSPLLFFLL LSFLMGCCLV AFFLLQRQPW GRQGSIEDLL
260 270 280 290 300
HSQVTLHSIK PRDTEDTGSV GAPVSSPGKG SVEVSVASLR PAQLAFIYSV
310 320 330 340 350
VAFVNALTNG VLPSVQTYSC LPYGPVAYHL SATLSSVASP LACFLPIFLP
360 370 380 390 400
NRSLLFLGVL TVLGTGFGTY NMAMAAMSPC PILQGHWGGE VLIVLSWMLF
410 420 430 440 450
VACLSYVKVM LGVILRDRSR SALLWCGAAV QLGSLIGALL MFPLVNVLKL
460
FSSADYCSLD CSA
Length:463
Mass (Da):50,130
Last modified:August 30, 2005 - v1
Checksum:i3D513AD8339D4B15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099097 mRNA. Translation: AAH99097.1.
RefSeqiNP_001032275.1. NM_001037198.1.
UniGeneiRn.14715.

Genome annotation databases

GeneIDi311536.
KEGGirno:311536.
UCSCiRGD:1304644. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099097 mRNA. Translation: AAH99097.1.
RefSeqiNP_001032275.1. NM_001037198.1.
UniGeneiRn.14715.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006828.

PTM databases

iPTMnetiQ4FZU9.

Proteomic databases

PaxDbiQ4FZU9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi311536.
KEGGirno:311536.
UCSCiRGD:1304644. rat.

Organism-specific databases

CTDi113278.
RGDi1304644. Slc52a3.

Phylogenomic databases

eggNOGiKOG4255. Eukaryota.
ENOG410YE1U. LUCA.
HOGENOMiHOG000247012.
HOVERGENiHBG051170.
InParanoidiQ4FZU9.
KOiK14620.
PhylomeDBiQ4FZU9.

Miscellaneous databases

PROiQ4FZU9.

Family and domain databases

InterProiIPR009357. Riboflavin_transptr.
[Graphical view]
PANTHERiPTHR12929. PTHR12929. 1 hit.
PfamiPF06237. DUF1011. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  2. "Identification and functional characterization of rat riboflavin transporter 2."
    Yamamoto S., Inoue K., Ohta K.Y., Fukatsu R., Maeda J.Y., Yoshida Y., Yuasa H.
    J. Biochem. 145:437-443(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, BIOPHYSICOCHEMICAL PROPERTIES.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-245 AND SER-269, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiS52A3_RAT
AccessioniPrimary (citable) accession number: Q4FZU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: August 30, 2005
Last modified: July 6, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.