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Protein

Annexin A8

Gene

Anxa8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi266 – 2661Calcium; via carbonyl oxygenBy similarity
Metal bindingi268 – 2681Calcium; via carbonyl oxygenBy similarity
Metal bindingi270 – 2701Calcium; via carbonyl oxygenBy similarity
Metal bindingi310 – 3101CalciumBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Blood coagulation, Hemostasis

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A8
Alternative name(s):
Annexin VIII
Annexin-8
Gene namesi
Name:Anxa8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi1307719. Anxa8.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327Annexin A8PRO_0000277887Add
BLAST

Proteomic databases

PaxDbiQ4FZU6.
PRIDEiQ4FZU6.

PTM databases

iPTMnetiQ4FZU6.

Expressioni

Gene expression databases

GenevisibleiQ4FZU6. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027464.

Structurei

3D structure databases

ProteinModelPortaliQ4FZU6.
SMRiQ4FZU6. Positions 8-326.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati38 – 9053Annexin 1Add
BLAST
Repeati110 – 16253Annexin 2Add
BLAST
Repeati195 – 24753Annexin 3Add
BLAST
Repeati270 – 32253Annexin 4Add
BLAST

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated
Contains 4 annexin repeats.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiQ4FZU6.
KOiK17096.
OMAiPHFNPDP.
OrthoDBiEOG74XS72.
PhylomeDBiQ4FZU6.
TreeFamiTF105452.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR009115. AnnexinVIII.
[Graphical view]
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR01808. ANNEXINVIII.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4FZU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWWKAWVEQ EGVSVKGSSH FNPDPDAETL YKAMKGIGTN EQAIIDVLTK
60 70 80 90 100
RSNVQRQQIA KSFKAQFGKD LTETLKSELS GKFERLIVAL MYPPYRYEAK
110 120 130 140 150
ELHDAMKGLG TKEGVIIEIL ASRTKNQLRE IMKAYEEDYG STLEEDIQGD
160 170 180 190 200
TSGYLERILV CLLQGCRDDV SGFVDPGLAL QDAQDLHAAG EKILGTDEMK
210 220 230 240 250
FITILCTRSA THLMRVFEEY EKIANKSIED SIKSETHGSL EEAMLTVVKC
260 270 280 290 300
TRNVHSYFAE RLYYAMKGAG TLDGTLIRNI VSRSEIDLNL IKSQFQKMYG
310 320
KTLSSMIMGD TSGYYKTALL NLVGTDL
Length:327
Mass (Da):36,706
Last modified:August 30, 2005 - v1
Checksum:i9E999F1D872A00E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099106 mRNA. Translation: AAH99106.1.
RefSeqiNP_001026824.1. NM_001031654.1.
UniGeneiRn.104326.

Genome annotation databases

EnsembliENSRNOT00000082186; ENSRNOP00000069969; ENSRNOG00000060949.
GeneIDi306283.
KEGGirno:306283.
UCSCiRGD:1307719. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099106 mRNA. Translation: AAH99106.1.
RefSeqiNP_001026824.1. NM_001031654.1.
UniGeneiRn.104326.

3D structure databases

ProteinModelPortaliQ4FZU6.
SMRiQ4FZU6. Positions 8-326.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027464.

PTM databases

iPTMnetiQ4FZU6.

Proteomic databases

PaxDbiQ4FZU6.
PRIDEiQ4FZU6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000082186; ENSRNOP00000069969; ENSRNOG00000060949.
GeneIDi306283.
KEGGirno:306283.
UCSCiRGD:1307719. rat.

Organism-specific databases

CTDi653145.
RGDi1307719. Anxa8.

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiQ4FZU6.
KOiK17096.
OMAiPHFNPDP.
OrthoDBiEOG74XS72.
PhylomeDBiQ4FZU6.
TreeFamiTF105452.

Miscellaneous databases

NextBioi655797.
PROiQ4FZU6.

Gene expression databases

GenevisibleiQ4FZU6. RN.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR009115. AnnexinVIII.
[Graphical view]
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR01808. ANNEXINVIII.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  2. Lubec G., Kang S.U., Lubec S.
    Submitted (SEP-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 36-56; 101-107 AND 234-249, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiANXA8_RAT
AccessioniPrimary (citable) accession number: Q4FZU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: August 30, 2005
Last modified: January 20, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.