Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ADAMTS-like protein 4

Gene

Adamtsl4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiR-RNO-5173214. O-glycosylation of TSR domain-containing proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
ADAMTS-like protein 4
Short name:
ADAMTSL-4
Gene namesi
Name:Adamtsl4Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1561012. Adamtsl4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 10301006ADAMTS-like protein 4Sequence analysisPRO_0000257968Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi451 – 4511N-linked (GlcNAc...)Sequence analysis
Glycosylationi731 – 7311N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Glycosylated (By similarity). Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ4FZU4.
PRIDEiQ4FZU4.

Expressioni

Gene expression databases

GenevisibleiQ4FZU4. RN.

Interactioni

Subunit structurei

Interacts with CTSB. Interacts with FBN1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063998.

Structurei

3D structure databases

ProteinModelPortaliQ4FZU4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 9145TSP type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini681 – 74060TSP type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini741 – 80060TSP type-1 3PROSITE-ProRule annotationAdd
BLAST
Domaini803 – 86563TSP type-1 4PROSITE-ProRule annotationAdd
BLAST
Domaini866 – 92560TSP type-1 5PROSITE-ProRule annotationAdd
BLAST
Domaini926 – 98257TSP type-1 6PROSITE-ProRule annotationAdd
BLAST
Domaini985 – 102238PLACPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PLAC domain.PROSITE-ProRule annotation
Contains 6 TSP type-1 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410KCTP. Eukaryota.
ENOG41102GD. LUCA.
GeneTreeiENSGT00760000118885.
HOVERGENiHBG080879.
InParanoidiQ4FZU4.
OMAiRCGRGQR.
OrthoDBiEOG73FQKT.
PhylomeDBiQ4FZU4.

Family and domain databases

InterProiIPR010294. ADAM_spacer1.
IPR010909. PLAC.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF05986. ADAM_spacer1. 1 hit.
PF08686. PLAC. 1 hit.
PF00090. TSP_1. 5 hits.
[Graphical view]
SMARTiSM00209. TSP1. 7 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 6 hits.
PROSITEiPS50900. PLAC. 1 hit.
PS50092. TSP1. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4FZU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELWLGRLWL YVMLLLLLLQ LCQDQELLGP SLQTPSEEDQ VPEGLWGPWG
60 70 80 90 100
RWASCSQPCG VGVQRRSRTC ELHPALSLPP RPPRHPEAPQ PRGQGSRPQT
110 120 130 140 150
PRDPQSLYRP QPRGRGGPLR GPASQVGREE TQEPRGAQRF RVRDPIKPGM
160 170 180 190 200
FGYGRVPFAL PLHRSRRLAH KPGQPKDSST AEETLPSQPP STEPASEKHS
210 220 230 240 250
PHMQPPELRA QSRSPSAETP RSGTAQTEVP SRTSSAPSDM GIPAPTSSFR
260 270 280 290 300
DSRSFQGSPE PRMPTSQGAE RQPHPFSPVT RSQLSRRHWR PPGSPHRSPD
310 320 330 340 350
GWLPLTRDSS PHWSLFAPSS PTPECSGESE QMRACSQEPC PPEQPDPRAL
360 370 380 390 400
QCAAFDSQEF MGQLYQWEPF TEVQGSQRCE LNCRPRGFRF YVRHTEKVQD
410 420 430 440 450
GTLCQPGSLD ICVAGHCLSP GCDGILGSGR RPDGCGVCGG DGSTCRLVSG
460 470 480 490 500
NLTDRGGPLG YQKILWIPAG ASHLRISQFR PSSNYLALRG PGGRSIINGN
510 520 530 540 550
WAVDPPGSYA AVGTVFQYNR PPREEGKGET LSAEGPTTQP VDVYMIFQED
560 570 580 590 600
NPGVFYQYVT SAAPESPSTM PPALQLQPEM LRGEPLLPSA PRPVRAPGTL
610 620 630 640 650
QRQARIPQVP PPTHVRTAMG SSAGYWKQVG HSECSASCGK GVWRPIFLCV
660 670 680 690 700
SRESGEELDE QSCAVGARPP ASPESCHRPP CPPYWEAGEW TSCSRSCGPG
710 720 730 740 750
TQHRQLLCRQ EFGGGGSSVP PERCGHLPRP NITQSCQLRL CGHWEISSPW
760 770 780 790 800
SQCSVRCGRG QRSRQVRCVG SNGHEVGKQE CASGPPPPPS REACDMGPCT
810 820 830 840 850
TAWFYSDWSS KCSAECGTGI QRRAVVCLRS GETLQGDPEA GSTEQGCPLR
860 870 880 890 900
SRPPDMRACS LGPCEKTWRW YTGPWSECSS ECGSGTQHRD IICVSKLGTK
910 920 930 940 950
FNVTSPSNCS HLPRPPALQP CQGQACEDQW FSTLWSPCSQ SCQGGVQTRE
960 970 980 990 1000
VQCLSSNHTL SSRCPPHLRP SRKRPCNSQP CNQRPDDQCK DSSPHCPLVV
1010 1020 1030
QARLCVYPYY TATCCRSCAH VLEQSQLEPA
Length:1,030
Mass (Da):112,785
Last modified:August 30, 2005 - v1
Checksum:iE38CC6486E08546B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099119 mRNA. Translation: AAH99119.1.
RefSeqiNP_001029184.1. NM_001034012.1.
UniGeneiRn.62115.

Genome annotation databases

EnsembliENSRNOT00000074156; ENSRNOP00000063998; ENSRNOG00000049385.
GeneIDi310670.
KEGGirno:310670.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099119 mRNA. Translation: AAH99119.1.
RefSeqiNP_001029184.1. NM_001034012.1.
UniGeneiRn.62115.

3D structure databases

ProteinModelPortaliQ4FZU4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063998.

Proteomic databases

PaxDbiQ4FZU4.
PRIDEiQ4FZU4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000074156; ENSRNOP00000063998; ENSRNOG00000049385.
GeneIDi310670.
KEGGirno:310670.

Organism-specific databases

CTDi54507.
RGDi1561012. Adamtsl4.

Phylogenomic databases

eggNOGiENOG410KCTP. Eukaryota.
ENOG41102GD. LUCA.
GeneTreeiENSGT00760000118885.
HOVERGENiHBG080879.
InParanoidiQ4FZU4.
OMAiRCGRGQR.
OrthoDBiEOG73FQKT.
PhylomeDBiQ4FZU4.

Enzyme and pathway databases

ReactomeiR-RNO-5173214. O-glycosylation of TSR domain-containing proteins.

Miscellaneous databases

NextBioi662400.
PROiQ4FZU4.

Gene expression databases

GenevisibleiQ4FZU4. RN.

Family and domain databases

InterProiIPR010294. ADAM_spacer1.
IPR010909. PLAC.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF05986. ADAM_spacer1. 1 hit.
PF08686. PLAC. 1 hit.
PF00090. TSP_1. 5 hits.
[Graphical view]
SMARTiSM00209. TSP1. 7 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 6 hits.
PROSITEiPS50900. PLAC. 1 hit.
PS50092. TSP1. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PlacentaImported.

Entry informationi

Entry nameiATL4_RAT
AccessioniPrimary (citable) accession number: Q4FZU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: August 30, 2005
Last modified: December 9, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Although similar to members of the ADAMTS family, it lacks the metalloprotease and disintegrin-like domains which are typical of that family.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.