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Protein

26S proteasome non-ATPase regulatory subunit 2

Gene

Psmd2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.By similarity
Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-1169091 Activation of NF-kappaB in B cells
R-RNO-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-RNO-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-RNO-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-RNO-174113 SCF-beta-TrCP mediated degradation of Emi1
R-RNO-174154 APC/C:Cdc20 mediated degradation of Securin
R-RNO-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-RNO-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-RNO-187577 SCF(Skp2)-mediated degradation of p27/p21
R-RNO-195253 Degradation of beta-catenin by the destruction complex
R-RNO-202424 Downstream TCR signaling
R-RNO-2467813 Separation of Sister Chromatids
R-RNO-2871837 FCERI mediated NF-kB activation
R-RNO-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-RNO-350562 Regulation of ornithine decarboxylase (ODC)
R-RNO-382556 ABC-family proteins mediated transport
R-RNO-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-RNO-4608870 Asymmetric localization of PCP proteins
R-RNO-4641257 Degradation of AXIN
R-RNO-4641258 Degradation of DVL
R-RNO-5358346 Hedgehog ligand biogenesis
R-RNO-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-RNO-5607764 CLEC7A (Dectin-1) signaling
R-RNO-5610780 Degradation of GLI1 by the proteasome
R-RNO-5610785 GLI3 is processed to GLI3R by the proteasome
R-RNO-5632684 Hedgehog 'on' state
R-RNO-5658442 Regulation of RAS by GAPs
R-RNO-5668541 TNFR2 non-canonical NF-kB pathway
R-RNO-5676590 NIK-->noncanonical NF-kB signaling
R-RNO-5687128 MAPK6/MAPK4 signaling
R-RNO-5689603 UCH proteinases
R-RNO-5689880 Ub-specific processing proteases
R-RNO-6798695 Neutrophil degranulation
R-RNO-68827 CDT1 association with the CDC6:ORC:origin complex
R-RNO-68949 Orc1 removal from chromatin
R-RNO-69017 CDK-mediated phosphorylation and removal of Cdc6
R-RNO-69229 Ubiquitin-dependent degradation of Cyclin D1
R-RNO-69481 G2/M Checkpoints
R-RNO-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-RNO-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-RNO-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-RNO-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-RNO-8939902 Regulation of RUNX2 expression and activity
R-RNO-8941858 Regulation of RUNX3 expression and activity
R-RNO-8948751 Regulation of PTEN stability and activity
R-RNO-9020702 Interleukin-1 signaling
R-RNO-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome non-ATPase regulatory subunit 2
Gene namesi
Name:Psmd2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi1305752 Psmd2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003170281 – 90826S proteasome non-ATPase regulatory subunit 2Add BLAST908

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei9PhosphothreonineBy similarity1
Modified residuei29PhosphoserineBy similarity1
Modified residuei147PhosphoserineBy similarity1
Modified residuei194PhosphotyrosineBy similarity1
Modified residuei361PhosphoserineCombined sources1
Modified residuei363PhosphoserineBy similarity1
Modified residuei551N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ4FZT9
PRIDEiQ4FZT9

PTM databases

iPTMnetiQ4FZT9
PhosphoSitePlusiQ4FZT9

Expressioni

Gene expression databases

BgeeiENSRNOG00000001719
GenevisibleiQ4FZT9 RN

Interactioni

Subunit structurei

Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases and few additional components including PSMD2 (By similarity). Interacts with RPGRIP1L (By similarity).By similarity

Protein-protein interaction databases

BioGridi252405, 1 interactor
IntActiQ4FZT9, 3 interactors
STRINGi10116.ENSRNOP00000002358

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6EPCelectron microscopy12.30Z1-908[»]
6EPDelectron microscopy15.40Z1-908[»]
6EPEelectron microscopy12.80Z1-908[»]
6EPFelectron microscopy11.80Z1-908[»]
SMRiQ4FZT9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati409 – 442PC 1Add BLAST34
Repeati443 – 479PC 2Add BLAST37
Repeati480 – 514PC 3Add BLAST35
Repeati517 – 551PC 4Add BLAST35
Repeati560 – 589PC 5Add BLAST30
Repeati692 – 723PC 6Add BLAST32
Repeati742 – 757PC 7Add BLAST16

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi623 – 641Glu/Lys-richAdd BLAST19

Sequence similaritiesi

Belongs to the proteasome subunit S2 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2005 Eukaryota
COG5110 LUCA
GeneTreeiENSGT00550000074983
HOGENOMiHOG000176022
HOVERGENiHBG001842
InParanoidiQ4FZT9
KOiK03028
OMAiMVDICAY
OrthoDBiEOG091G04TC
PhylomeDBiQ4FZT9
TreeFamiTF105739

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR016643 26S_Psome_Rpn1
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR002015 Proteasome/cyclosome_rpt
PANTHERiPTHR10943:SF1 PTHR10943:SF1, 1 hit
PfamiView protein in Pfam
PF01851 PC_rep, 2 hits
PIRSFiPIRSF015965 26S_Psome_Rpn1, 1 hit
SUPFAMiSSF48371 SSF48371, 4 hits

Sequencei

Sequence statusi: Complete.

Q4FZT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEGGRDKTP VQSQQPSATA PSGADEKSSG KERRDAGEKD KEQELSEEDK
60 70 80 90 100
QLQDELEMLV ERLGEKDTSL YRPALEELRR QIRSSTTSMT SVPKPLKFLR
110 120 130 140 150
PHYGKLKEIY ENMAPGENKC FAADIISVLA MTMSGERECL KYRLVGSQEE
160 170 180 190 200
LASWGHEYVR HLAGEVAKEW QELDDAEKAQ REPLLTLVKE IVPYNMAHNA
210 220 230 240 250
EHEACDLLME IEQVDMLEKD IDENAYSKVC LYLTSCVNYV PEPENSALLR
260 270 280 290 300
CALGVFRKFS RFPEALRLAL MLNDMELVED IFTSCKDVVV QKQMAFMLGR
310 320 330 340 350
HGVFLELSED VEEYEDLTEI MSNVQLNSNF LALARELDIM EPKVPDDIYK
360 370 380 390 400
THLENNRFGG SGSQVDSARM NLASSFVNGF VNAAFGQDKL LTDDGNKWLY
410 420 430 440 450
KNKDHGMLSA AASLGMILLW DVDGGLTQID KYLYSSEDYI KSGALLACGI
460 470 480 490 500
VNSGVRNECD PALALLSDYV LHNSNTMRLG SIFGLGLAYA GSNREDVLTL
510 520 530 540 550
LLPVMGDSKS SMEVAGVTAL ACGMIAVGSC NGDVTSTILQ TIMEKSETEL
560 570 580 590 600
KDTYARWLPL GLGLNHLGKG EAIEAILAAL EVVSEPFRSF ANTLVDVCAY
610 620 630 640 650
AGSGNVLKVQ QLLHICSEHF DSKEKEEDKD KKEKKDKDKK EAPADMGAHQ
660 670 680 690 700
GVAVLGIALI AMGEEIGAEM ALRTFGHLLR YGEPTLRRAV PLALALISVS
710 720 730 740 750
NPRLNILDTL SKFSHDADPE VSYNSIFAMG MVGSGTNNAR LAAMLRQLAQ
760 770 780 790 800
YHAKDPNNLF MVRLAQGLTH LGKGTLTLCP YHSDRQLMSQ VAVAGLLTVL
810 820 830 840 850
VSFLDVRNII LGKSHYVLYG LVAAMQPRML VTFDEELRPL PVSVRVGQAV
860 870 880 890 900
DVVGQAGKPK TITGFQTHTT PVLLAHGERA ELATEEFLPV TPILEGFVIL

RKNPNYNL
Length:908
Mass (Da):100,188
Last modified:August 30, 2005 - v1
Checksum:iFAB93C42A49E54FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099135 mRNA Translation: AAH99135.1
RefSeqiNP_001026809.1, NM_001031639.1
UniGeneiRn.29909

Genome annotation databases

EnsembliENSRNOT00000002358; ENSRNOP00000002358; ENSRNOG00000001719
GeneIDi287984
KEGGirno:287984

Similar proteinsi

Entry informationi

Entry nameiPSMD2_RAT
AccessioniPrimary (citable) accession number: Q4FZT9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 30, 2005
Last modified: May 23, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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