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Protein

Stomatin-like protein 2, mitochondrial

Gene

Stoml2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Stomatin-like protein 2, mitochondrial
Short name:
SLP-2
Gene namesi
Name:Stoml2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1308285. Stoml2.

Subcellular locationi

  • Cell membrane By similarity; Peripheral membrane protein By similarity
  • Mitochondrion By similarity
  • Mitochondrion inner membrane By similarity; Lipid-anchor By similarity
  • Mitochondrion intermembrane space By similarity
  • Membrane raft By similarity
  • Cytoplasmcytoskeleton By similarity

  • Note: Behaves as an integral membrane protein of the mitochondrion despite the absence of a detectable transmembrane domain. Also associates with the actin cytoskeleton and membrane rafts in activated T-cells. A minor pool is associated with the plasma membrane and is enriched at the immunological synapse in activated T-cells.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 28MitochondrionSequence analysisAdd BLAST28
ChainiPRO_000028849429 – 353Stomatin-like protein 2, mitochondrialAdd BLAST325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei17Phosphoserine; by PKC/PRKCZBy similarity1
Modified residuei124PhosphotyrosineBy similarity1
Modified residuei145N6-acetyllysine; alternateBy similarity1
Modified residuei145N6-succinyllysine; alternateBy similarity1
Modified residuei233N6-acetyllysineBy similarity1
Modified residuei330PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ4FZT0.
PRIDEiQ4FZT0.

PTM databases

iPTMnetiQ4FZT0.
PhosphoSitePlusiQ4FZT0.

Expressioni

Gene expression databases

BgeeiENSRNOG00000009535.
GenevisibleiQ4FZT0. RN.

Interactioni

Subunit structurei

Forms homooligomers. Interacts with MFN2; may form heterooligomers. Interacts with PHB and PHB2; recruits them to cardiolipin-enriched mitochondrial membranes and stabilizes them. Interacts with CACNA2D2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi255804. 1 interactor.
IntActiQ4FZT0. 1 interactor.
STRINGi10116.ENSRNOP00000013151.

Structurei

3D structure databases

ProteinModelPortaliQ4FZT0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili215 – 252Sequence analysisAdd BLAST38

Sequence similaritiesi

Belongs to the band 7/mec-2 family.Curated

Keywords - Domaini

Coiled coil, Transit peptide

Phylogenomic databases

eggNOGiKOG2620. Eukaryota.
COG0330. LUCA.
GeneTreeiENSGT00550000074454.
HOGENOMiHOG000217038.
HOVERGENiHBG061488.
InParanoidiQ4FZT0.
OMAiPQQNAWV.
OrthoDBiEOG091G0MSB.
PhylomeDBiQ4FZT0.
TreeFamiTF105750.

Family and domain databases

InterProiIPR001107. Band_7.
IPR032435. Band_7_C.
IPR001972. Stomatin_fam.
[Graphical view]
PANTHERiPTHR10264. PTHR10264. 1 hit.
PfamiPF01145. Band_7. 1 hit.
PF16200. Band_7_C. 1 hit.
[Graphical view]
PRINTSiPR00721. STOMATIN.
SMARTiSM00244. PHB. 1 hit.
[Graphical view]
SUPFAMiSSF117892. SSF117892. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4FZT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLARAARGTG ALLLRGSVQA SGRIPRRASS GLPRNTVILF VPQQEAWVVE
60 70 80 90 100
RMGRFHRILE PGLNVLIPVL DRIRYVQSLK EIVINVPEQS AVTLDNVTLQ
110 120 130 140 150
IDGVLYLRIM DPYKASYGVE DPEYAVTQLA QTTMRSELGK LSLDKVFRER
160 170 180 190 200
ESLNANIVDA INQAADCWGI RCLRYEIKDI HVPPRVKESM QMQVEAERRK
210 220 230 240 250
RATVLESEGT RESAINVAEG KKQAQILASE AEKAEQINQA AGEASAVLAK
260 270 280 290 300
AKAKAEAIRI LAGALTQHNG DAAASLTVAE QYVSAFSKLA KDSNTVLLPS
310 320 330 340 350
NPSDVTSMVA QAMGVYGALT KAPVPGAQNS SEARRDVQTT DTSIEELGRV

KLS
Length:353
Mass (Da):38,414
Last modified:August 30, 2005 - v1
Checksum:i9E8ED01781B7B08A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099164 mRNA. Translation: AAH99164.1.
RefSeqiNP_001026816.1. NM_001031646.1.
UniGeneiRn.2208.

Genome annotation databases

EnsembliENSRNOT00000013151; ENSRNOP00000013151; ENSRNOG00000009535.
GeneIDi298203.
KEGGirno:298203.
UCSCiRGD:1308285. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099164 mRNA. Translation: AAH99164.1.
RefSeqiNP_001026816.1. NM_001031646.1.
UniGeneiRn.2208.

3D structure databases

ProteinModelPortaliQ4FZT0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi255804. 1 interactor.
IntActiQ4FZT0. 1 interactor.
STRINGi10116.ENSRNOP00000013151.

PTM databases

iPTMnetiQ4FZT0.
PhosphoSitePlusiQ4FZT0.

Proteomic databases

PaxDbiQ4FZT0.
PRIDEiQ4FZT0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000013151; ENSRNOP00000013151; ENSRNOG00000009535.
GeneIDi298203.
KEGGirno:298203.
UCSCiRGD:1308285. rat.

Organism-specific databases

CTDi30968.
RGDi1308285. Stoml2.

Phylogenomic databases

eggNOGiKOG2620. Eukaryota.
COG0330. LUCA.
GeneTreeiENSGT00550000074454.
HOGENOMiHOG000217038.
HOVERGENiHBG061488.
InParanoidiQ4FZT0.
OMAiPQQNAWV.
OrthoDBiEOG091G0MSB.
PhylomeDBiQ4FZT0.
TreeFamiTF105750.

Miscellaneous databases

PROiQ4FZT0.

Gene expression databases

BgeeiENSRNOG00000009535.
GenevisibleiQ4FZT0. RN.

Family and domain databases

InterProiIPR001107. Band_7.
IPR032435. Band_7_C.
IPR001972. Stomatin_fam.
[Graphical view]
PANTHERiPTHR10264. PTHR10264. 1 hit.
PfamiPF01145. Band_7. 1 hit.
PF16200. Band_7_C. 1 hit.
[Graphical view]
PRINTSiPR00721. STOMATIN.
SMARTiSM00244. PHB. 1 hit.
[Graphical view]
SUPFAMiSSF117892. SSF117892. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSTML2_RAT
AccessioniPrimary (citable) accession number: Q4FZT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: August 30, 2005
Last modified: November 2, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.