Unreviewed, UniProtKB/TrEMBL Q4FZR6 (Q4FZR6_RAT)

Names and origin

Protein names

Submitted name:
    Lck protein EMBL AAH99218.1

Gene names

Name:

Lck RGD 1586168

Organism

Rattus norvegicus (Rat) EMBL AAH99218.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	379 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. Spearmint SPM020635
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. Contains 1 protein kinase domain.

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU000304V2 Spearmint SPM020635 Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase RuleBase RU000307V5 Spearmint SPM020635
Gene Ontology (GO)
Biological process	B cell receptor signaling pathway Inferred from electronic annotation. Source: Compara aging Inferred from expression pattern. Source: RGD apoptosis Inferred from expression pattern. Source: RGD peptidyl-tyrosine phosphorylation Inferred from direct assay. Source: RGD positive regulation of gamma-delta T cell differentiation Inferred from electronic annotation. Source: Compara protein amino acid autophosphorylation Inferred from direct assay. Source: RGD regulation of T cell receptor signaling pathway Inferred from electronic annotation. Source: Compara release of sequestered calcium ion into cytosol Inferred from electronic annotation. Source: Compara response to hydrogen peroxide Inferred from direct assay. Source: RGD response to zinc ion Inferred from expression pattern. Source: RGD
Cellular component	endocytic vesicle Inferred from direct assay. Source: RGD plasma membrane Inferred from direct assay. Source: RGD
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein complex binding Inferred from direct assay. Source: RGD protein tyrosine kinase activity Inferred from direct assay. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAH99218.1

Sequences

	Sequence		Length	Mass (Da)
	Q4FZR6-1 [UniParc]. Last modified August 30, 2005. Version 1. Checksum: 7CDEB573BAFB53AB	FASTA	379	43,336
	10 20 30 40 50 60 NLSRKDAERQ LLAPGNTHGS FLIRESESTA GSFSLSVRDF DQNQGEVVKH YKIRNLDNGG 70 80 90 100 110 120 FYISPRITFP GLHDLVRHYT NASDGLCTKL SRPCQTQKPQ KPWWEDEWEV PRETLKLVER 130 140 150 160 170 180 LGAGQFGEVW MGYYNGHTKV AVKSLKQGSM SPDAFLAEAN LMKQLQHPRL VRLYAVVTQE 190 200 210 220 230 240 PIYIITEYME NGSLVDFLKT PSGIKLNVNK LLDMAAQIAE GMAFIEEQNY IHRDLRAANI 250 260 270 280 290 300 LVSDTLSCKI ADFGLARLIE DNEYTAREGA KFPIKWTAPE AINYGTFTIK SDVWSFGILL 310 320 330 340 350 360 TEIVTHGRIP YPGMTNPEVI QNLEKGYRMV RPDNCPEELY HLMMLCWKER PEDRPTFDYL 370 RSVLDDFFTA TEGQYQPQP

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thymus EMBL AAH99218.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC099218 mRNA. Translation: AAH99218.1.
IPI	IPI00205116.
UniGene	Rn.222163
3D structure databases
SMR	Q4FZR6. Positions 2-379.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4FZR6.
Genome annotation databases
Ensembl	ENSRNOT00000012936; ENSRNOP00000012936; ENSRNOG00000009705; Rattus norvegicus. [Genome view]
Phylogenomic databases
HOVERGEN	Q4FZR6.
InParanoid	Q4FZR6.
Gene expression databases
Genevestigator	Q4FZR6.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR000980. SH2. IPR020749. Tyr_kinase_non-rcpt_Lck. IPR020635. Tyr_Pkinase_cat_dom. IPR020685. Tyr_prot_kinase. IPR008266. Tyr_prot_kinase_AS. [Graphical view]
Gene3D	G3DSA:3.30.505.10. SH2. 1 hit.
PANTHER	PTHR23256:SF260. Tyr_kinase_non-rcpt_Lck. 1 hit. PTHR23256. Tyr_prot_kinase. 1 hit.
Pfam	PF00017. SH2. 1 hit. [Graphical view]
PRINTS	PR00401. SH2DOMAIN.
SMART	SM00252. SH2. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS50001. SH2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q4FZR6_RAT

Accession

Primary (citable) accession number: Q4FZR6

Entry history

Integrated into UniProtKB/TrEMBL:	August 30, 2005
Last sequence update:	August 30, 2005
Last modified:	February 9, 2010
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)