Lck protein - Rattus norvegicus (Rat)

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Unreviewed, UniProtKB/TrEMBL Q4FZR6 (Q4FZR6_RAT)

Last modified February 9, 2010. Version 46. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information

Names and origin

Protein names

Submitted name:
Lck protein EMBL AAH99218.1

Gene names

Name:

Lck RGD 1586168

Organism

Rattus norvegicus (Rat) EMBL AAH99218.1

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	379 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. Spearmint SPM020635

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family.

Contains 1 protein kinase domain.

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU000304V2 Spearmint SPM020635 Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase RuleBase RU000307V5 Spearmint SPM020635
Gene Ontology (GO)
Biological process	B cell receptor signaling pathway Inferred from electronic annotation. Source: Compara aging Inferred from expression pattern. Source: RGD apoptosis Inferred from expression pattern. Source: RGD peptidyl-tyrosine phosphorylation Inferred from direct assay. Source: RGD positive regulation of gamma-delta T cell differentiation Inferred from electronic annotation. Source: Compara protein amino acid autophosphorylation Inferred from direct assay. Source: RGD regulation of T cell receptor signaling pathway Inferred from electronic annotation. Source: Compara release of sequestered calcium ion into cytosol Inferred from electronic annotation. Source: Compara response to hydrogen peroxide Inferred from direct assay. Source: RGD response to zinc ion Inferred from expression pattern. Source: RGD
Cellular component	endocytic vesicle Inferred from direct assay. Source: RGD plasma membrane Inferred from direct assay. Source: RGD
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein complex binding Inferred from direct assay. Source: RGD protein tyrosine kinase activity Inferred from direct assay. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Experimental info

Non-terminal residue

1

EMBL AAH99218.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q4FZR6-1 [UniParc].

Last modified August 30, 2005. Version 1.
Checksum: 7CDEB573BAFB53AB
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379

43,336

        10         20         30         40         50         60 
NLSRKDAERQ LLAPGNTHGS FLIRESESTA GSFSLSVRDF DQNQGEVVKH YKIRNLDNGG 

        70         80         90        100        110        120 
FYISPRITFP GLHDLVRHYT NASDGLCTKL SRPCQTQKPQ KPWWEDEWEV PRETLKLVER 

       130        140        150        160        170        180 
LGAGQFGEVW MGYYNGHTKV AVKSLKQGSM SPDAFLAEAN LMKQLQHPRL VRLYAVVTQE 

       190        200        210        220        230        240 
PIYIITEYME NGSLVDFLKT PSGIKLNVNK LLDMAAQIAE GMAFIEEQNY IHRDLRAANI 

       250        260        270        280        290        300 
LVSDTLSCKI ADFGLARLIE DNEYTAREGA KFPIKWTAPE AINYGTFTIK SDVWSFGILL 

       310        320        330        340        350        360 
TEIVTHGRIP YPGMTNPEVI QNLEKGYRMV RPDNCPEELY HLMMLCWKER PEDRPTFDYL 

       370 
RSVLDDFFTA TEGQYQPQP

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thymus EMBL AAH99218.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC099218 mRNA. Translation: AAH99218.1.
IPI	IPI00205116.
UniGene	Rn.222163
3D structure databases
SMR	Q4FZR6. Positions 2-379.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4FZR6.
Genome annotation databases
Ensembl	ENSRNOT00000012936; ENSRNOP00000012936; ENSRNOG00000009705; Rattus norvegicus. [Genome view]
Phylogenomic databases
HOVERGEN	Q4FZR6.
InParanoid	Q4FZR6.
Gene expression databases
Genevestigator	Q4FZR6.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR000980. SH2. IPR020749. Tyr_kinase_non-rcpt_Lck. IPR020635. Tyr_Pkinase_cat_dom. IPR020685. Tyr_prot_kinase. IPR008266. Tyr_prot_kinase_AS. [Graphical view]
Gene3D	G3DSA:3.30.505.10. SH2. 1 hit.
PANTHER	PTHR23256:SF260. Tyr_kinase_non-rcpt_Lck. 1 hit. PTHR23256. Tyr_prot_kinase. 1 hit.
Pfam	PF00017. SH2. 1 hit. [Graphical view]
PRINTS	PR00401. SH2DOMAIN.
SMART	SM00252. SH2. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS50001. SH2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q4FZR6_RAT

Accession

Primary (citable) accession number: Q4FZR6

Entry history

Integrated into UniProtKB/TrEMBL:	August 30, 2005
Last sequence update:	August 30, 2005
Last modified:	February 9, 2010
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information