Acd

Functionⁱ

Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.By similarity

GO - Molecular functionⁱ

DNA polymerase binding Source: Ensembl
macromolecular complex binding Source: Ensembl
telomeric DNA binding Source: Ensembl

Complete GO annotation...

GO - Biological processⁱ

embryonic limb morphogenesis Source: Ensembl
establishment of protein localization to telomere Source: Ensembl
intracellular protein transport Source: Ensembl
negative regulation of telomere maintenance via telomerase Source: Ensembl
positive regulation of single-stranded telomeric DNA binding Source: Ensembl
positive regulation of telomerase activity Source: Ensembl
positive regulation of telomere maintenance via telomerase Source: Ensembl
protection from non-homologous end joining at telomere Source: Ensembl
segmentation Source: Ensembl
skeletal system development Source: Ensembl
telomere assembly Source: Ensembl
urogenital system development Source: Ensembl

Complete GO annotation...

Keywordsⁱ

Molecular function	DNA-binding

Molecular function

DNA-binding

Enzyme and pathway databases

Reactomeⁱ	R-RNO-171306. Packaging Of Telomere Ends. R-RNO-2559586. DNA Damage/Telomere Stress Induced Senescence.

Reactomeⁱ

R-RNO-171306. Packaging Of Telomere Ends.
R-RNO-2559586. DNA Damage/Telomere Stress Induced Senescence.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Adrenocortical dysplasia protein homolog
Gene namesⁱ	Name:Acd
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 19

Organism-specific databases

Rat genome database More...RGDⁱ	1565053. Acd.

RGDⁱ

1565053. Acd.

Subcellular locationⁱ

GO - Cellular componentⁱ

nuclear body Source: Ensembl
shelterin complex Source: Ensembl

Complete GO annotation...

Keywords - Cellular componentⁱ

Chromosome, Nucleus, Telomere

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000239021	1 – 417	Adrenocortical dysplasia protein homologAdd BLAST		417

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	25	PhosphoserineCombined sources	1
Modified residueⁱ	313	PhosphoserineBy similarity	1
Modified residueⁱ	317	PhosphoserineBy similarity	1
Cross-linkⁱ	348	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q4FZR5.

PaxDbⁱ

Q4FZR5.

PTM databases

iPTMnetⁱ	Q4FZR5.
PhosphoSitePlusⁱ	Q4FZR5.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000038973.
Genevisibleⁱ	Q4FZR5. RN.

Interactionⁱ

Subunit structureⁱ

Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Forms heterodimers with POT1. Identified in a complex with POT1 and single-stranded telomeric DNA. Interacts with STN1 and TINF2.By similarity

GO - Molecular functionⁱ

DNA polymerase binding Source: Ensembl

Complete GO annotation...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000056334.

STRINGⁱ

10116.ENSRNOP00000056334.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q4FZR5.
SMRⁱ	Q4FZR5.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	156 – 245	Interaction with POT1By similarityAdd BLAST		90

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	11 – 13	PWI		3

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	236 – 317	Ser-richAdd BLAST		82

Phylogenomic databases

eggNOGⁱ	ENOG410IGMZ. Eukaryota. ENOG410YTBM. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004877.
HOGENOMⁱ	HOG000033778.
HOVERGENⁱ	HBG080817.
InParanoidⁱ	Q4FZR5.
KEGG Orthology (KO) More...KOⁱ	K11114.
OMAⁱ	WEEKEFG.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05BM.
PhylomeDBⁱ	Q4FZR5.
TreeFamⁱ	TF338536.

Family and domain databases

Gene3Dⁱ	2.40.200.10. 1 hit.
InterProⁱ	View protein in InterPro IPR028631. ACD. IPR023113. TEBP_beta_domain.
PANTHERⁱ	PTHR14487. PTHR14487. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q4FZR5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSNSGRLVLR PWIRELILGS ETLSSPQAGH LLKVLQDSET PGPSSAPDTP 
        60         70         80         90        100
DTGAVLLVSD GTHSVRCVVT RNAIDTSDWE EKEFGFRGTE GRLLLLQACG 
       110        120        130        140        150
LRIQVAQDYA PAEFYLQVDR FNLLPTEQPR VQVTGCNQDS DVQKKLNKCL 
       160        170        180        190        200
EDHLSESASS SAGLTLSQLL DEVKEDGDHR GALVRLAESC LVLQGPFTAR 
       210        220        230        240        250
PLTHWATSCS QATEEAVFTV PSFLLHISEN EEQILSSIDS SQKAQENPAS 
       260        270        280        290        300
PSLMPQEESG ASVSLLSALP TSDPGQKDNS QPPPTVCSTS PRAQAPSSTP 
       310        320        330        340        350
CSSTPSSPLL TCSPSLSPLR HAPTSYQACE TRTQFHKLEF RELQWPIKRR 
       360        370        380        390        400
QLLPRTGAQE PHSVWEPPER HRDTSAFQYK YGTPSASLHT QVQTARLSPQ 
       410 
LVAWALNIVM ESELPQV

Length:417

Mass (Da):45,591

Last modified:August 30, 2005 - v1

Checksum:ⁱ0D71769328AEF1B7

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC099222 mRNA. Translation: AAH99222.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001032270.1. NM_001037193.1.
UniGeneⁱ	Rn.8611.

Genome annotation databases

Ensemblⁱ	ENSRNOT00000059577; ENSRNOP00000056334; ENSRNOG00000038973.
GeneIDⁱ	307798.
KEGGⁱ	rno:307798.
UCSC genome browser More...UCSCⁱ	RGD:1565053. rat.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC099222 mRNA. Translation: AAH99222.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001032270.1. NM_001037193.1.
UniGeneⁱ	Rn.8611.

3D structure databases

ProteinModelPortalⁱ	Q4FZR5.
SMRⁱ	Q4FZR5.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000056334.

STRINGⁱ

10116.ENSRNOP00000056334.

PTM databases

iPTMnetⁱ	Q4FZR5.
PhosphoSitePlusⁱ	Q4FZR5.

Proteomic databases

PaxDbⁱ	Q4FZR5.

PaxDbⁱ

Q4FZR5.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000059577; ENSRNOP00000056334; ENSRNOG00000038973.
GeneIDⁱ	307798.
KEGGⁱ	rno:307798.
UCSC genome browser More...UCSCⁱ	RGD:1565053. rat.

Organism-specific databases

CTDⁱ	65057.
Rat genome database More...RGDⁱ	1565053. Acd.

Phylogenomic databases

eggNOGⁱ	ENOG410IGMZ. Eukaryota. ENOG410YTBM. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004877.
HOGENOMⁱ	HOG000033778.
HOVERGENⁱ	HBG080817.
InParanoidⁱ	Q4FZR5.
KEGG Orthology (KO) More...KOⁱ	K11114.
OMAⁱ	WEEKEFG.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05BM.
PhylomeDBⁱ	Q4FZR5.
TreeFamⁱ	TF338536.

Enzyme and pathway databases

Reactomeⁱ	R-RNO-171306. Packaging Of Telomere Ends. R-RNO-2559586. DNA Damage/Telomere Stress Induced Senescence.

Reactomeⁱ

R-RNO-171306. Packaging Of Telomere Ends.
R-RNO-2559586. DNA Damage/Telomere Stress Induced Senescence.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q4FZR5.

PROⁱ

PR:Q4FZR5.

Gene expression databases

Bgeeⁱ	ENSRNOG00000038973.
Genevisibleⁱ	Q4FZR5. RN.

Family and domain databases

Gene3Dⁱ	2.40.200.10. 1 hit.
InterProⁱ	View protein in InterPro IPR028631. ACD. IPR023113. TEBP_beta_domain.
PANTHERⁱ	PTHR14487. PTHR14487. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ACD_RAT
Accessionⁱ	Q4FZR5Primary (citable) accession number: Q4FZR5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
	Last sequence update:	August 30, 2005
	Last modified:	August 30, 2017
	This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q4FZR5 (ACD_RAT)

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Adrenocortical dysplasia protein homolog

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ