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Protein

Adrenocortical dysplasia protein homolog

Gene

Acd

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-RNO-171306. Packaging Of Telomere Ends.
R-RNO-2559586. DNA Damage/Telomere Stress Induced Senescence.

Names & Taxonomyi

Protein namesi
Recommended name:
Adrenocortical dysplasia protein homolog
Gene namesi
Name:Acd
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1565053. Acd.

Subcellular locationi

  • Nucleus By similarity
  • Chromosometelomere By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 417417Adrenocortical dysplasia protein homologPRO_0000239021Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei25 – 251PhosphoserineCombined sources
Modified residuei313 – 3131PhosphoserineBy similarity
Modified residuei317 – 3171PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ4FZR5.
PRIDEiQ4FZR5.

PTM databases

iPTMnetiQ4FZR5.
PhosphoSiteiQ4FZR5.

Expressioni

Gene expression databases

GenevisibleiQ4FZR5. RN.

Interactioni

Subunit structurei

Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Forms heterodimers with POT1. Identified in a complex with POT1 and single-stranded telomeric DNA. Interacts with STN1/OBFC1 and TINF2.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000056334.

Structurei

3D structure databases

ProteinModelPortaliQ4FZR5.
SMRiQ4FZR5. Positions 4-153.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni156 – 24590Interaction with POT1By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi11 – 133PWI

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi236 – 31782Ser-richAdd
BLAST

Phylogenomic databases

eggNOGiENOG410IGMZ. Eukaryota.
ENOG410YTBM. LUCA.
GeneTreeiENSGT00390000004877.
HOGENOMiHOG000033778.
HOVERGENiHBG080817.
InParanoidiQ4FZR5.
KOiK11114.
OMAiWEEKEFG.
OrthoDBiEOG7HHWSJ.
PhylomeDBiQ4FZR5.
TreeFamiTF338536.

Family and domain databases

InterProiIPR028631. ACD.
[Graphical view]
PANTHERiPTHR14487. PTHR14487. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4FZR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNSGRLVLR PWIRELILGS ETLSSPQAGH LLKVLQDSET PGPSSAPDTP
60 70 80 90 100
DTGAVLLVSD GTHSVRCVVT RNAIDTSDWE EKEFGFRGTE GRLLLLQACG
110 120 130 140 150
LRIQVAQDYA PAEFYLQVDR FNLLPTEQPR VQVTGCNQDS DVQKKLNKCL
160 170 180 190 200
EDHLSESASS SAGLTLSQLL DEVKEDGDHR GALVRLAESC LVLQGPFTAR
210 220 230 240 250
PLTHWATSCS QATEEAVFTV PSFLLHISEN EEQILSSIDS SQKAQENPAS
260 270 280 290 300
PSLMPQEESG ASVSLLSALP TSDPGQKDNS QPPPTVCSTS PRAQAPSSTP
310 320 330 340 350
CSSTPSSPLL TCSPSLSPLR HAPTSYQACE TRTQFHKLEF RELQWPIKRR
360 370 380 390 400
QLLPRTGAQE PHSVWEPPER HRDTSAFQYK YGTPSASLHT QVQTARLSPQ
410
LVAWALNIVM ESELPQV
Length:417
Mass (Da):45,591
Last modified:August 30, 2005 - v1
Checksum:i0D71769328AEF1B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099222 mRNA. Translation: AAH99222.1.
RefSeqiNP_001032270.1. NM_001037193.1.
UniGeneiRn.8611.

Genome annotation databases

EnsembliENSRNOT00000059577; ENSRNOP00000056334; ENSRNOG00000038973.
GeneIDi307798.
KEGGirno:307798.
UCSCiRGD:1565053. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099222 mRNA. Translation: AAH99222.1.
RefSeqiNP_001032270.1. NM_001037193.1.
UniGeneiRn.8611.

3D structure databases

ProteinModelPortaliQ4FZR5.
SMRiQ4FZR5. Positions 4-153.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000056334.

PTM databases

iPTMnetiQ4FZR5.
PhosphoSiteiQ4FZR5.

Proteomic databases

PaxDbiQ4FZR5.
PRIDEiQ4FZR5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000059577; ENSRNOP00000056334; ENSRNOG00000038973.
GeneIDi307798.
KEGGirno:307798.
UCSCiRGD:1565053. rat.

Organism-specific databases

CTDi65057.
RGDi1565053. Acd.

Phylogenomic databases

eggNOGiENOG410IGMZ. Eukaryota.
ENOG410YTBM. LUCA.
GeneTreeiENSGT00390000004877.
HOGENOMiHOG000033778.
HOVERGENiHBG080817.
InParanoidiQ4FZR5.
KOiK11114.
OMAiWEEKEFG.
OrthoDBiEOG7HHWSJ.
PhylomeDBiQ4FZR5.
TreeFamiTF338536.

Enzyme and pathway databases

ReactomeiR-RNO-171306. Packaging Of Telomere Ends.
R-RNO-2559586. DNA Damage/Telomere Stress Induced Senescence.

Miscellaneous databases

PROiQ4FZR5.

Gene expression databases

GenevisibleiQ4FZR5. RN.

Family and domain databases

InterProiIPR028631. ACD.
[Graphical view]
PANTHERiPTHR14487. PTHR14487. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiACD_RAT
AccessioniPrimary (citable) accession number: Q4FZR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: August 30, 2005
Last modified: July 6, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.