UniProtKB - Q4FZR5 (ACD_RAT)
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Protein
Adrenocortical dysplasia protein homolog
Gene
Acd
Organism
Rattus norvegicus (Rat)
Status
Functioni
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.By similarity
GO - Molecular functioni
- DNA polymerase binding Source: RGD
- protein-containing complex binding Source: RGD
- telomeric DNA binding Source: RGD
GO - Biological processi
- embryonic limb morphogenesis Source: RGD
- establishment of protein localization to telomere Source: RGD
- intracellular protein transport Source: RGD
- negative regulation of telomere maintenance via telomerase Source: RGD
- positive regulation of single-stranded telomeric DNA binding Source: RGD
- positive regulation of telomerase activity Source: RGD
- positive regulation of telomere maintenance via telomerase Source: RGD
- protection from non-homologous end joining at telomere Source: RGD
- protein localization to chromosome, telomeric region Source: RGD
- segmentation Source: RGD
- skeletal system development Source: RGD
- telomere assembly Source: RGD
- telomere capping Source: RGD
- telomere maintenance Source: RGD
- urogenital system development Source: RGD
Keywordsi
Molecular function | DNA-binding |
Enzyme and pathway databases
Reactomei | R-RNO-2559586 DNA Damage/Telomere Stress Induced Senescence |
Names & Taxonomyi
Protein namesi | Recommended name: Adrenocortical dysplasia protein homolog |
Gene namesi | Name:Acd |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1565053 Acd |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000239021 | 1 – 417 | Adrenocortical dysplasia protein homologAdd BLAST | 417 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 25 | PhosphoserineCombined sources | 1 | |
Modified residuei | 313 | PhosphoserineBy similarity | 1 | |
Modified residuei | 317 | PhosphoserineBy similarity | 1 | |
Cross-linki | 348 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | Q4FZR5 |
PTM databases
iPTMneti | Q4FZR5 |
PhosphoSitePlusi | Q4FZR5 |
Interactioni
Subunit structurei
Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Forms heterodimers with POT1. Identified in a complex with POT1 and single-stranded telomeric DNA. Interacts with STN1 and TINF2.By similarity
GO - Molecular functioni
- DNA polymerase binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000056334 |
Structurei
3D structure databases
ProteinModelPortali | Q4FZR5 |
SMRi | Q4FZR5 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 156 – 245 | Interaction with POT1By similarityAdd BLAST | 90 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 11 – 13 | PWI | 3 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 236 – 317 | Ser-richAdd BLAST | 82 |
Phylogenomic databases
eggNOGi | ENOG410IGMZ Eukaryota ENOG410YTBM LUCA |
GeneTreei | ENSGT00390000004877 |
HOGENOMi | HOG000033778 |
HOVERGENi | HBG080817 |
InParanoidi | Q4FZR5 |
KOi | K11114 |
OMAi | WEEKEFG |
OrthoDBi | EOG091G05BM |
PhylomeDBi | Q4FZR5 |
TreeFami | TF338536 |
Family and domain databases
InterProi | View protein in InterPro IPR028631 ACD |
PANTHERi | PTHR14487 PTHR14487, 2 hits |
i Sequence
Sequence statusi: Complete.
Q4FZR5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSNSGRLVLR PWIRELILGS ETLSSPQAGH LLKVLQDSET PGPSSAPDTP
60 70 80 90 100
DTGAVLLVSD GTHSVRCVVT RNAIDTSDWE EKEFGFRGTE GRLLLLQACG
110 120 130 140 150
LRIQVAQDYA PAEFYLQVDR FNLLPTEQPR VQVTGCNQDS DVQKKLNKCL
160 170 180 190 200
EDHLSESASS SAGLTLSQLL DEVKEDGDHR GALVRLAESC LVLQGPFTAR
210 220 230 240 250
PLTHWATSCS QATEEAVFTV PSFLLHISEN EEQILSSIDS SQKAQENPAS
260 270 280 290 300
PSLMPQEESG ASVSLLSALP TSDPGQKDNS QPPPTVCSTS PRAQAPSSTP
310 320 330 340 350
CSSTPSSPLL TCSPSLSPLR HAPTSYQACE TRTQFHKLEF RELQWPIKRR
360 370 380 390 400
QLLPRTGAQE PHSVWEPPER HRDTSAFQYK YGTPSASLHT QVQTARLSPQ
410
LVAWALNIVM ESELPQV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC099222 mRNA Translation: AAH99222.1 |
RefSeqi | NP_001032270.1, NM_001037193.1 |
UniGenei | Rn.8611 |
Genome annotation databases
Ensembli | ENSRNOT00000059577; ENSRNOP00000056334; ENSRNOG00000038973 |
GeneIDi | 307798 |
KEGGi | rno:307798 |
UCSCi | RGD:1565053 rat |
Similar proteinsi
Entry informationi
Entry namei | ACD_RAT | |
Accessioni | Q4FZR5Primary (citable) accession number: Q4FZR5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2006 |
Last sequence update: | August 30, 2005 | |
Last modified: | April 25, 2018 | |
This is version 91 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |