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Protein

Adrenocortical dysplasia protein homolog

Gene

Acd

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

ReactomeiR-RNO-171306. Packaging Of Telomere Ends.
R-RNO-2559586. DNA Damage/Telomere Stress Induced Senescence.

Names & Taxonomyi

Protein namesi
Recommended name:
Adrenocortical dysplasia protein homolog
Gene namesi
Name:Acd
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1565053. Acd.

Subcellular locationi

  • Nucleus By similarity
  • Chromosometelomere By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002390211 – 417Adrenocortical dysplasia protein homologAdd BLAST417

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25PhosphoserineCombined sources1
Modified residuei313PhosphoserineBy similarity1
Modified residuei317PhosphoserineBy similarity1
Cross-linki348Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ4FZR5.

PTM databases

iPTMnetiQ4FZR5.
PhosphoSitePlusiQ4FZR5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000038973.
GenevisibleiQ4FZR5. RN.

Interactioni

Subunit structurei

Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Forms heterodimers with POT1. Identified in a complex with POT1 and single-stranded telomeric DNA. Interacts with STN1 and TINF2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000056334.

Structurei

3D structure databases

ProteinModelPortaliQ4FZR5.
SMRiQ4FZR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni156 – 245Interaction with POT1By similarityAdd BLAST90

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi11 – 13PWI3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi236 – 317Ser-richAdd BLAST82

Phylogenomic databases

eggNOGiENOG410IGMZ. Eukaryota.
ENOG410YTBM. LUCA.
GeneTreeiENSGT00390000004877.
HOGENOMiHOG000033778.
HOVERGENiHBG080817.
InParanoidiQ4FZR5.
KOiK11114.
OMAiWEEKEFG.
OrthoDBiEOG091G05BM.
PhylomeDBiQ4FZR5.
TreeFamiTF338536.

Family and domain databases

Gene3Di2.40.200.10. 1 hit.
InterProiView protein in InterPro
IPR028631. ACD.
IPR023113. TEBP_beta_domain.
PANTHERiPTHR14487. PTHR14487. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4FZR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNSGRLVLR PWIRELILGS ETLSSPQAGH LLKVLQDSET PGPSSAPDTP
60 70 80 90 100
DTGAVLLVSD GTHSVRCVVT RNAIDTSDWE EKEFGFRGTE GRLLLLQACG
110 120 130 140 150
LRIQVAQDYA PAEFYLQVDR FNLLPTEQPR VQVTGCNQDS DVQKKLNKCL
160 170 180 190 200
EDHLSESASS SAGLTLSQLL DEVKEDGDHR GALVRLAESC LVLQGPFTAR
210 220 230 240 250
PLTHWATSCS QATEEAVFTV PSFLLHISEN EEQILSSIDS SQKAQENPAS
260 270 280 290 300
PSLMPQEESG ASVSLLSALP TSDPGQKDNS QPPPTVCSTS PRAQAPSSTP
310 320 330 340 350
CSSTPSSPLL TCSPSLSPLR HAPTSYQACE TRTQFHKLEF RELQWPIKRR
360 370 380 390 400
QLLPRTGAQE PHSVWEPPER HRDTSAFQYK YGTPSASLHT QVQTARLSPQ
410
LVAWALNIVM ESELPQV
Length:417
Mass (Da):45,591
Last modified:August 30, 2005 - v1
Checksum:i0D71769328AEF1B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099222 mRNA. Translation: AAH99222.1.
RefSeqiNP_001032270.1. NM_001037193.1.
UniGeneiRn.8611.

Genome annotation databases

EnsembliENSRNOT00000059577; ENSRNOP00000056334; ENSRNOG00000038973.
GeneIDi307798.
KEGGirno:307798.
UCSCiRGD:1565053. rat.

Entry informationi

Entry nameiACD_RAT
AccessioniPrimary (citable) accession number: Q4FZR5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: August 30, 2005
Last modified: August 30, 2017
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome