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Protein

Histone deacetylase complex subunit SAP18

Gene

Sap18

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits the formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function.UniRule annotation

GO - Biological processi

Keywordsi

Molecular functionRepressorUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase complex subunit SAP18UniRule annotation
Gene namesi
Name:Sap18Imported
ORF Names:mCG_3526Imported, mCG_49778Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

PTM / Processingi

Proteomic databases

PRIDEiQ4FZH3

Structurei

3D structure databases

SMRiQ4FZH3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAP18 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3391 Eukaryota
ENOG4111FBB LUCA
HOGENOMiHOG000238745
HOVERGENiHBG003465
KOiK14324

Family and domain databases

InterProiView protein in InterPro
IPR017250 Hist_deAcase_cplx_SAP18
IPR010516 SAP18
PANTHERiPTHR13082 PTHR13082, 1 hit
PfamiView protein in Pfam
PF06487 SAP18, 1 hit
PIRSFiPIRSF037637 HDAC_SAP18, 1 hit

Sequencei

Sequence statusi: Complete.

Q4FZH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVESRVTQE EIKKEPEKPI DREKTCPLLL RVFTTNNGRH HRMDEFSRGN
60 70 80 90 100
VPSSELQIYT WMDATLKELT SLVKEVYPEA RKKGTHFNFA IVFMDLKRPG
110 120 130 140 150
YRVKEIGSTM SGRKGTDDSM TLQSQKFQIG DYLDIAITPP NRAPPSSGRM

RPY
Length:153
Mass (Da):17,595
Last modified:August 30, 2005 - v1
Checksum:i68FE63E6EAD04E6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099480 mRNA Translation: AAH99480.1
AK133619 mRNA Translation: BAE21751.1
AK144904 mRNA Translation: BAE26125.1
AK146928 mRNA Translation: BAE27539.1
CH466525 Genomic DNA Translation: EDL11186.1
CH466535 Genomic DNA Translation: EDL36164.1
RefSeqiNP_033145.2, NM_009119.3
UniGeneiMm.290178
Mm.30173
Mm.344671

Genome annotation databases

GeneIDi20220
KEGGimmu:20220

Similar proteinsi

Entry informationi

Entry nameiQ4FZH3_MOUSE
AccessioniPrimary (citable) accession number: Q4FZH3
Entry historyiIntegrated into UniProtKB/TrEMBL: August 30, 2005
Last sequence update: August 30, 2005
Last modified: June 20, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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