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Protein

Probable ATP-dependent RNA helicase DDX49

Gene

Ddx49

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi46 – 538ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-6791226. Major pathway of rRNA processing in the nucleolus.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent RNA helicase DDX49 (EC:3.6.4.13)
Alternative name(s):
DEAD box protein 49
Gene namesi
Name:Ddx49
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2136689. Ddx49.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 480480Probable ATP-dependent RNA helicase DDX49PRO_0000055053Add
BLAST

Proteomic databases

EPDiQ4FZF3.
MaxQBiQ4FZF3.
PaxDbiQ4FZF3.
PeptideAtlasiQ4FZF3.
PRIDEiQ4FZF3.

PTM databases

iPTMnetiQ4FZF3.
PhosphoSiteiQ4FZF3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000057788.
CleanExiMM_DDX49.
GenevisibleiQ4FZF3. MM.

Interactioni

Protein-protein interaction databases

BioGridi231521. 1 interaction.
STRINGi10090.ENSMUSP00000008004.

Structurei

3D structure databases

ProteinModelPortaliQ4FZF3.
SMRiQ4FZF3. Positions 4-448.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 207175Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini218 – 382165Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi2 – 3029Q motifAdd
BLAST
Motifi152 – 1554DEAD box

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0330. Eukaryota.
ENOG410XQU7. LUCA.
GeneTreeiENSGT00730000111231.
HOGENOMiHOG000268802.
HOVERGENiHBG100512.
InParanoidiQ4FZF3.
KOiK14778.
OMAiNYDVPRN.
OrthoDBiEOG091G07QH.
PhylomeDBiQ4FZF3.
TreeFamiTF320511.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4FZF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGFAEIGLS SWLVEQCRQL GLKQPTPVQL GCIPAILEGR DCLGCAKTGS
60 70 80 90 100
GKTAAFVLPI LQKLSEDPYG IFCLVLTPTR ELAYQIAEQF RVLGKPLGLK
110 120 130 140 150
DCIIVGGMDM VAQALELSRK PHVVIATPGR LADHLRSSNT FNMKKIQFLV
160 170 180 190 200
MDEADRLLEQ GCTDFTTDLE TILAAVPARR QTLLFSATLT DTLKELQGLA
210 220 230 240 250
TNEPFFWEAQ ATVRTVEQLD QRYLLVPEKV KDAYLVHLVQ TFQDQLEDCS
260 270 280 290 300
IIIFTNTCKT CQILCMMLRK FNFPTVALHS MMKQKERFAA LAKFKSSIYR
310 320 330 340 350
ILIATDVASR GLDIPTVQVV INHNTPGLPK IYIHRVGRTA RAGRQGQAIT
360 370 380 390 400
LVTQYDIHLL HAIEEQIKQQ LAELVVEEAE VLQILTQVNV VRRECEIKLE
410 420 430 440 450
ASHFDEKKEI NKRKQMILEG KDPDLEAKRK AELAKIKQQN RRFKEKVGQT
460 470 480
LRRQKAGSTV RRSRPPRSRP QEPAQAEAQD
Length:480
Mass (Da):54,094
Last modified:August 30, 2005 - v1
Checksum:i526E8383D5CF8933
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099554 mRNA. Translation: AAH99554.1.
CCDSiCCDS22364.1.
RefSeqiNP_001020093.2. NM_001024922.2.
UniGeneiMm.388127.
Mm.440659.

Genome annotation databases

EnsembliENSMUST00000008004; ENSMUSP00000008004; ENSMUSG00000057788.
GeneIDi234374.
KEGGimmu:234374.
UCSCiuc009lzu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099554 mRNA. Translation: AAH99554.1.
CCDSiCCDS22364.1.
RefSeqiNP_001020093.2. NM_001024922.2.
UniGeneiMm.388127.
Mm.440659.

3D structure databases

ProteinModelPortaliQ4FZF3.
SMRiQ4FZF3. Positions 4-448.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231521. 1 interaction.
STRINGi10090.ENSMUSP00000008004.

PTM databases

iPTMnetiQ4FZF3.
PhosphoSiteiQ4FZF3.

Proteomic databases

EPDiQ4FZF3.
MaxQBiQ4FZF3.
PaxDbiQ4FZF3.
PeptideAtlasiQ4FZF3.
PRIDEiQ4FZF3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000008004; ENSMUSP00000008004; ENSMUSG00000057788.
GeneIDi234374.
KEGGimmu:234374.
UCSCiuc009lzu.1. mouse.

Organism-specific databases

CTDi54555.
MGIiMGI:2136689. Ddx49.

Phylogenomic databases

eggNOGiKOG0330. Eukaryota.
ENOG410XQU7. LUCA.
GeneTreeiENSGT00730000111231.
HOGENOMiHOG000268802.
HOVERGENiHBG100512.
InParanoidiQ4FZF3.
KOiK14778.
OMAiNYDVPRN.
OrthoDBiEOG091G07QH.
PhylomeDBiQ4FZF3.
TreeFamiTF320511.

Enzyme and pathway databases

ReactomeiR-MMU-6791226. Major pathway of rRNA processing in the nucleolus.

Miscellaneous databases

PROiQ4FZF3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000057788.
CleanExiMM_DDX49.
GenevisibleiQ4FZF3. MM.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDDX49_MOUSE
AccessioniPrimary (citable) accession number: Q4FZF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: August 30, 2005
Last modified: September 7, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.