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Q4FX34

- Q4FX34_LEIMA

UniProt

Q4FX34 - Q4FX34_LEIMA

Protein
Submitted name:

Aspartate aminotransferase

Gene

asat

Organism
Leishmania major
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (30 Aug 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. L-aspartate:2-oxoglutarate aminotransferase activity Source: UniProtKB-EC
    2. L-phenylalanine:2-oxoglutarate aminotransferase activity Source: UniProtKB-EC
    3. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. biosynthetic process Source: InterPro
    2. cellular amino acid metabolic process Source: InterPro

    Keywords - Molecular functioni

    AminotransferaseImported, Transferase

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Aspartate aminotransferaseImported (EC:2.6.1.1Imported)
    Submitted name:
    Putative aspartate aminotransferaseImported (EC:2.6.1.1Imported)
    Gene namesi
    Name:asatImported
    ORF Names:LMJF_35_0820Imported
    OrganismiLeishmania majorImported
    Taxonomic identifieri5664 [NCBI]
    Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
    ProteomesiUP000000542: Chromosome 35

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4H51X-ray1.85A/B1-412[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000185898.
    KOiK14454.
    OMAiMAGLTHE.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    InterProiIPR004839. Aminotransferase_I/II.
    IPR000796. Asp_trans.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11879. PTHR11879. 1 hit.
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00799. TRANSAMINASE.
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q4FX34-1 [UniParc]FASTAAdd to Basket

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    MSTQAAMTTA ERWQKIQAQA PDVIFDLAKR AAAAKGPKAN LVIGAYRDEQ    50
    GRPYPLRVVR KAEQLLLDMN LDYEYLPISG YQPFIDEAVK IIYGNTVELE 100
    NLVAVQTLSG TGAVSLGAKL LTRVFDAETT PIYLSDPTWP NHYGVVKAAG 150
    WKNICTYAYY DPKTVSLNFE GMKKDILAAP DGSVFILHQC AHNPTGVDPS 200
    QEQWNEIASL MLAKHHQVFF DSAYQGYASG SLDTDAYAAR LFARRGIEVL 250
    LAQSFSKNMG LYSERAGTLS LLLKDKTKRA DVKSVMDSLI REEYTCPPAH 300
    GARLAHLILS NNELRKEWEA ELSAMAERIR TMRRTVYDEL LRLQTPGSWE 350
    HVINQIGMFS FLGLSKAQCE YCQNHNIFIT VSGRANMAGL THETALMLAQ 400
    TINDAVRNVN RE 412
    Length:412
    Mass (Da):45,990
    Last modified:August 30, 2005 - v1
    Checksum:iA6398BDDF00CB5BB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM117189 Genomic DNA. Translation: CAJ40954.1.
    FR796431 Genomic DNA. Translation: CBZ12710.1.
    RefSeqiXP_003722477.1. XM_003722429.1.

    Genome annotation databases

    EnsemblProtistsiLmjF.35.0820:mRNA; LmjF.35.0820:pep; LmjF.35.0820.
    GeneIDi12982266.
    KEGGilma:LMJF_35_0820.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM117189 Genomic DNA. Translation: CAJ40954.1 .
    FR796431 Genomic DNA. Translation: CBZ12710.1 .
    RefSeqi XP_003722477.1. XM_003722429.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4H51 X-ray 1.85 A/B 1-412 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi LmjF.35.0820:mRNA ; LmjF.35.0820:pep ; LmjF.35.0820 .
    GeneIDi 12982266.
    KEGGi lma:LMJF_35_0820.

    Phylogenomic databases

    HOGENOMi HOG000185898.
    KOi K14454.
    OMAi MAGLTHE.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    InterProi IPR004839. Aminotransferase_I/II.
    IPR000796. Asp_trans.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11879. PTHR11879. 1 hit.
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00799. TRANSAMINASE.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the kinetoplastid parasite, Leishmania major."
      Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G., Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A., Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M., Bianchettin G.
      , Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E., Ciarloni L., Clayton C., Coulson R.M.R., Cronin A., Cruz A.K., Davies R.M., De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N., Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A., Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S., Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M., Masuy D., Matthews K., Michaeli S., Mottram J.C., Mueller-Auer S., Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M., Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E., Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C., Rutter S., Saunders D., Schaefer M., Schein J., Schwartz D.C., Seeger K., Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V., Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J., Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D., Barrell B.G., Myler P.J.
      Science 309:436-442(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: FriedlinImported and MHOM/IL/81/FriedlinImported.
    2. "Towards multilocus sequence typing of the Leishmania donovani complex: resolving genotypes and haplotypes for five polymorphic metabolic enzymes (ASAT, GPI, NH1, NH2, PGD)."
      Mauricio I.L., Yeo M., Baghaei M., Doto D., Pratlong F., Zemanova E., Dedet J.P., Lukes J., Miles M.A.
      Int. J. Parasitol. 36:757-769(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MHOM/SU/1973/5-ASKHImported.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: FriedlinImported.
    4. Aslett M.
      Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: FriedlinImported.
    5. "Chromosome and gene copy number variation allow genomic structural differences between species and strains of Leishmania."
      Hilley J.D., Rogers M., Wilkes J., Dickens N.J., Bates P., Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D., Saad W., Seeger K., Berriman M., Smith D.F., Hertz-Fowler C., Mottram J.C.
      Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Friedlin.
    6. "Crystal structure of a putative Aspartate Aminotransferase from Leishmania major Friedlin."
      Seattle Structural Genomics Center for Infectious Disease (SSGCID)
      Abendroth J., Edwards T.E., Staker B.L., Stewart L.J., Myler P.
      Submitted (SEP-2012) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).

    Entry informationi

    Entry nameiQ4FX34_LEIMA
    AccessioniPrimary (citable) accession number: Q4FX34
    Secondary accession number(s): E9AEQ7, Q18L72
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 30, 2005
    Last sequence update: August 30, 2005
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3