Q4FX34 (Q4FX34_LEIMA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Aspartate aminotransferase EMBL CAJ40954.1
EC=2.6.1.1 EMBL CAJ40954.1

Submitted name:
Putative aspartate aminotransferase EMBL CBZ12710.1
EC=2.6.1.1 EMBL CBZ12710.1

Gene names

Name:	asat EMBL CAJ40954.1
ORF Names:	LMJF_35_0820 EMBL CBZ12710.1

Organism

Leishmania major [Reference proteome] EMBL CAJ40954.1

Taxonomic identifier

5664 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Leishmaniinae › Leishmania › Leishmania › Leishmania major species complex

Protein attributes

Sequence length	412 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Molecular function	Aminotransferase EMBL CAJ40954.1 Transferase
Technical term	3D-structure PDB 4H51 Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	L-aspartate:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC L-phenylalanine:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q4FX34 [UniParc]. Last modified August 30, 2005. Version 1. Checksum: A6398BDDF00CB5BB	FASTA	412	45,990
	10 20 30 40 50 60 MSTQAAMTTA ERWQKIQAQA PDVIFDLAKR AAAAKGPKAN LVIGAYRDEQ GRPYPLRVVR 70 80 90 100 110 120 KAEQLLLDMN LDYEYLPISG YQPFIDEAVK IIYGNTVELE NLVAVQTLSG TGAVSLGAKL 130 140 150 160 170 180 LTRVFDAETT PIYLSDPTWP NHYGVVKAAG WKNICTYAYY DPKTVSLNFE GMKKDILAAP 190 200 210 220 230 240 DGSVFILHQC AHNPTGVDPS QEQWNEIASL MLAKHHQVFF DSAYQGYASG SLDTDAYAAR 250 260 270 280 290 300 LFARRGIEVL LAQSFSKNMG LYSERAGTLS LLLKDKTKRA DVKSVMDSLI REEYTCPPAH 310 320 330 340 350 360 GARLAHLILS NNELRKEWEA ELSAMAERIR TMRRTVYDEL LRLQTPGSWE HVINQIGMFS 370 380 390 400 410 FLGLSKAQCE YCQNHNIFIT VSGRANMAGL THETALMLAQ TINDAVRNVN RE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome of the kinetoplastid parasite, Leishmania major." Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G., Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A., Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M., Bianchettin G. , Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E., Ciarloni L., Clayton C., Coulson R.M.R., Cronin A., Cruz A.K., Davies R.M., De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N., Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A., Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S., Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M., Masuy D., Matthews K., Michaeli S., Mottram J.C., Mueller-Auer S., Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M., Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E., Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C., Rutter S., Saunders D., Schaefer M., Schein J., Schwartz D.C., Seeger K., Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V., Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J., Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D., Barrell B.G., Myler P.J. Science 309:436-442(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Friedlin and MHOM/IL/81/Friedlin.
[2]	"Towards multilocus sequence typing of the Leishmania donovani complex: resolving genotypes and haplotypes for five polymorphic metabolic enzymes (ASAT, GPI, NH1, NH2, PGD)." Mauricio I.L., Yeo M., Baghaei M., Doto D., Pratlong F., Zemanova E., Dedet J.P., Lukes J., Miles M.A. Int. J. Parasitol. 36:757-769(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: MHOM/SU/1973/5-ASKH EMBL CAJ40954.1.
[3]	Aslett M. Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Friedlin.
[4]	"Chromosome and gene copy number variation allow genomic structural differences between species and strains of Leishmania." Hilley J.D., Rogers M., Wilkes J., Dickens N.J., Bates P., Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D., Saad W., Seeger K., Berriman M., Smith D.F., Hertz-Fowler C., Mottram J.C. Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Friedlin.
[5]	"Crystal structure of a putative Aspartate Aminotransferase from Leishmania major Friedlin." Seattle Structural Genomics Center for Infectious Disease (SSGCID) Abendroth J., Edwards T.E., Staker B.L., Stewart L.J., Myler P. Submitted (SEP-2012) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AM117189 Genomic DNA. Translation: CAJ40954.1.
FR796431 Genomic DNA. Translation: CBZ12710.1.

RefSeq

XP_003722477.1. XM_003722429.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4H51	X-ray	1.85	A/B	1-412	[»]

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblProtists

LmjF.35.0820:mRNA; LmjF.35.0820:pep; LmjF.35.0820.

GeneID

12982266.

KEGG

lma:LMJF_35_0820.

Phylogenomic databases

HOGENOM

HOG000185898.

OMA

QWNEIAS.

ProtClustDB

PTZ00376.

Family and domain databases

Gene3D

3.40.640.10. 1 hit.

InterPro

IPR004839. Aminotransferase_I/II.
IPR000796. Asp_trans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]

PANTHER

PTHR11879. PTHR11879. 1 hit.

Pfam

PF00155. Aminotran_1_2. 1 hit.
[Graphical view]

PRINTS

PR00799. TRANSAMINASE.

SUPFAM

SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.

ProtoNet

Search...

Entry information

Entry name

Q4FX34_LEIMA

Accession

Primary (citable) accession number: Q4FX34
Secondary accession number(s): E9AEQ7, Q18L72

Entry history

Integrated into UniProtKB/TrEMBL:	August 30, 2005
Last sequence update:	August 30, 2005
Last modified:	May 1, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)