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Protein
Submitted name:

Aspartate aminotransferase

Gene

asat

Organism
Leishmania major
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. L-aspartate:2-oxoglutarate aminotransferase activity Source: UniProtKB-EC
  2. L-phenylalanine:2-oxoglutarate aminotransferase activity Source: UniProtKB-EC
  3. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. biosynthetic process Source: InterPro
  2. cellular amino acid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

AminotransferaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Aspartate aminotransferaseImported (EC:2.6.1.1Imported)
Submitted name:
Complete genome, chromosome 35Imported (EC:2.6.1.1Imported)
Gene namesi
Name:asatImported
ORF Names:LMJF_35_0820Imported
OrganismiLeishmania majorImported
Taxonomic identifieri5664 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
ProteomesiUP000000542 Componenti: Chromosome 35

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4H51X-ray1.85A/B1-412[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000185898.
KOiK14454.
OMAiKDCKAIK.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR000796. Asp_trans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11879. PTHR11879. 1 hit.
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
PRINTSiPR00799. TRANSAMINASE.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4FX34-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTQAAMTTA ERWQKIQAQA PDVIFDLAKR AAAAKGPKAN LVIGAYRDEQ
60 70 80 90 100
GRPYPLRVVR KAEQLLLDMN LDYEYLPISG YQPFIDEAVK IIYGNTVELE
110 120 130 140 150
NLVAVQTLSG TGAVSLGAKL LTRVFDAETT PIYLSDPTWP NHYGVVKAAG
160 170 180 190 200
WKNICTYAYY DPKTVSLNFE GMKKDILAAP DGSVFILHQC AHNPTGVDPS
210 220 230 240 250
QEQWNEIASL MLAKHHQVFF DSAYQGYASG SLDTDAYAAR LFARRGIEVL
260 270 280 290 300
LAQSFSKNMG LYSERAGTLS LLLKDKTKRA DVKSVMDSLI REEYTCPPAH
310 320 330 340 350
GARLAHLILS NNELRKEWEA ELSAMAERIR TMRRTVYDEL LRLQTPGSWE
360 370 380 390 400
HVINQIGMFS FLGLSKAQCE YCQNHNIFIT VSGRANMAGL THETALMLAQ
410
TINDAVRNVN RE
Length:412
Mass (Da):45,990
Last modified:August 30, 2005 - v1
Checksum:iA6398BDDF00CB5BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM117189 Genomic DNA. Translation: CAJ40954.1.
FR796431 Genomic DNA. Translation: CBZ12710.1.
RefSeqiXP_003722477.1. XM_003722429.1.

Genome annotation databases

EnsemblProtistsiLmjF.35.0820:mRNA; LmjF.35.0820:pep; LmjF.35.0820.
GeneIDi12982266.
KEGGilma:LMJF_35_0820.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM117189 Genomic DNA. Translation: CAJ40954.1.
FR796431 Genomic DNA. Translation: CBZ12710.1.
RefSeqiXP_003722477.1. XM_003722429.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4H51X-ray1.85A/B1-412[»]
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiLmjF.35.0820:mRNA; LmjF.35.0820:pep; LmjF.35.0820.
GeneIDi12982266.
KEGGilma:LMJF_35_0820.

Phylogenomic databases

HOGENOMiHOG000185898.
KOiK14454.
OMAiKDCKAIK.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR000796. Asp_trans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11879. PTHR11879. 1 hit.
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
PRINTSiPR00799. TRANSAMINASE.
SUPFAMiSSF53383. SSF53383. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome of the kinetoplastid parasite, Leishmania major."
    Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G., Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A., Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M., Bianchettin G.
    , Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E., Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M., De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N., Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A., Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S., Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M., Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S., Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M., Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E., Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C., Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K., Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V., Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J., Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D., Barrell B., Myler P.J.
    Science 309:436-442(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FriedlinImported and MHOM/IL/81/FriedlinImported.
  2. "Towards multilocus sequence typing of the Leishmania donovani complex: resolving genotypes and haplotypes for five polymorphic metabolic enzymes (ASAT, GPI, NH1, NH2, PGD)."
    Mauricio I.L., Yeo M., Baghaei M., Doto D., Pratlong F., Zemanova E., Dedet J.P., Lukes J., Miles M.A.
    Int. J. Parasitol. 36:757-769(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MHOM/SU/1973/5-ASKHImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FriedlinImported.
  4. Aslett M.
    Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: FriedlinImported.
  5. "Chromosome and gene copy number variation allow genomic structural differences between species and strains of Leishmania."
    Hilley J.D., Rogers M., Wilkes J., Dickens N.J., Bates P., Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D., Saad W., Seeger K., Berriman M., Smith D.F., Hertz-Fowler C., Mottram J.C.
    Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Friedlin.
  6. "Crystal structure of a putative Aspartate Aminotransferase from Leishmania major Friedlin."
    Seattle Structural Genomics Center for Infectious Disease (SSGCID)
    Abendroth J., Edwards T.E., Staker B.L., Stewart L.J., Myler P.
    Submitted (SEP-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).

Entry informationi

Entry nameiQ4FX34_LEIMA
AccessioniPrimary (citable) accession number: Q4FX34
Secondary accession number(s): E9AEQ7, Q18L72
Entry historyi
Integrated into UniProtKB/TrEMBL: August 30, 2005
Last sequence update: August 30, 2005
Last modified: April 29, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.