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Q4FVL5 (IF2_PSYA2) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Translation initiation factor IF-2
Gene names
Name:infB
Ordered Locus Names:Psyc_0069
OrganismPsychrobacter arcticus (strain DSM 17307 / 273-4) [Complete proteome] [HAMAP]
Taxonomic identifier259536 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter

Protein attributes

Sequence length908 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity. HAMAP-Rule MF_00100

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00100.

Sequence similarities

Belongs to the IF-2 family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandGTP-binding
Nucleotide-binding
   Molecular functionInitiation factor
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

GTPase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

translation initiation factor activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 908908Translation initiation factor IF-2 HAMAP-Rule MF_00100
PRO_0000228233

Regions

Nucleotide binding418 – 4258GTP By similarity
Nucleotide binding464 – 4685GTP By similarity
Nucleotide binding518 – 5214GTP By similarity
Region412 – 560149G-domain HAMAP-Rule MF_00100

Sequences

Sequence LengthMass (Da)Tools
Q4FVL5 [UniParc].

Last modified August 30, 2005. Version 1.
Checksum: 7B5B55166A0CB41C

FASTA90899,875
        10         20         30         40         50         60 
MADKTVKELA DMVSKTASAV QQQLVDAGLP ARAEGDLVTE LEQEKLVTYL KQSHGQEEKR 

        70         80         90        100        110        120 
RISLKSKTTS TARVTGSSGK SKSVNVEVRK KKVFEKPDPE KMAEELAARE QAMIESQARA 

       130        140        150        160        170        180 
AKDAEDRAAT KKKSEERQAA TLAAMRASLG SSKKSDDKND DISTSVVVKK GGKTTIEVKP 

       190        200        210        220        230        240 
KEQPKKKVAA TKPKVETAVE RKAREVREKE EARLREIETE TRRTQAEEAQ KRTLEQMRKM 

       250        260        270        280        290        300 
AGQYTDQPAT EVRKDEPLAE GLVGDALEES FEKERREIKR GTSSTTARGR GRRKNQDERE 

       310        320        330        340        350        360 
IKNRKNGLRS SQSAQHKFEK PVEKIVYDVE ISEQITVSDL AQRMAVKARE VTKLLMKMGE 

       370        380        390        400        410        420 
IARESDTIDQ ATASLIVEEM GHNPVPVSDT KVEDDLQDAA DERSSNVQTR PPVVTIMGHV 

       430        440        450        460        470        480 
DHGKTSLLDK IRETKVATGE AGGITQHIGA YHVKTARGVI TFLDTPGHAA FSAMRSRGAQ 

       490        500        510        520        530        540 
ATDIVVLVVA ADDGMMPQTE EAIDHARAAG TPLIVAINKM DKPSADPDRV LNELTAKEVV 

       550        560        570        580        590        600 
SEEWGGDTPM ARISAKTGDG IDELLELISL QAELMELEAP LDGPAQGVVI ESRLEKGRGP 

       610        620        630        640        650        660 
VVSVLVKKGT LKQGDLVLAG EHYGKVRAMT DEHGQRIQSA GPSIPVEILG LPETPAAGSE 

       670        680        690        700        710        720 
FLVLTDEKKA REVADFRTNR ERERQLERQN AMRLESMFDQ MEQGNVSYLN IVLKTDVRGS 

       730        740        750        760        770        780 
LEALLSALNE LSTDEVKVRV ISSGVGPISE SDVTLAESSE AVLLGFNVRA DATARRKSDT 

       790        800        810        820        830        840 
ANMDIRYYSV IYGLIDDVKA AMSGMLAPEH REKILGVADV REVFRSSKFG AAAGCMVVEG 

       850        860        870        880        890        900 
TIYRNKPIRV LRNDQVIFTG QLQSLRRYKE DVNEVRTGME CGLAVRGYDV EAGDKIEVFE 


IQEFARTI 

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References

[1]"The genome sequence of Psychrobacter arcticus 273-4, a psychroactive Siberian permafrost bacterium, reveals mechanisms for adaptation to low-temperature growth."
Ayala-del-Rio H.L., Chain P.S., Grzymski J.J., Ponder M.A., Ivanova N., Bergholz P.W., Di Bartolo G., Hauser L., Land M., Bakermans C., Rodrigues D., Klappenbach J., Zarka D., Larimer F., Richardson P., Murray A., Thomashow M., Tiedje J.M.
Appl. Environ. Microbiol. 76:2304-2312(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 17307 / 273-4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000082 Genomic DNA. Translation: AAZ17943.1.
RefSeqYP_263377.1. NC_007204.1.

3D structure databases

ProteinModelPortalQ4FVL5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING259536.Psyc_0069.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAZ17943; AAZ17943; Psyc_0069.
GeneID3514157.
KEGGpar:Psyc_0069.
PATRIC23054275. VBIPsyArc98534_0082.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0532.
HOGENOMHOG000076907.
KOK02519.
OMAIKFMFKM.
OrthoDBEOG67HJSV.
ProtClustDBPRK05306.

Enzyme and pathway databases

BioCycPARC259536:GI3A-71-MONOMER.

Family and domain databases

Gene3D3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_00100_B. IF_2_B.
InterProIPR009061. DNA-bd_dom_put.
IPR000795. EF_GTP-bd_dom.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 1 hit.
[Graphical view]
SUPFAMSSF46955. SSF46955. 1 hit.
SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEPS01176. IF2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIF2_PSYA2
AccessionPrimary (citable) accession number: Q4FVL5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: August 30, 2005
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Translation initiation factors

List of translation initiation factor entries