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Q4FVL5

- IF2_PSYA2

UniProt

Q4FVL5 - IF2_PSYA2

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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Psychrobacter arcticus (strain DSM 17307 / 273-4)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi418 – 4258GTPUniRule annotation
Nucleotide bindingi464 – 4685GTPUniRule annotation
Nucleotide bindingi518 – 5214GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: UniProtKB-HAMAP
  2. GTP binding Source: UniProtKB-KW
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPARC259536:GI3A-71-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:Psyc_0069
OrganismiPsychrobacter arcticus (strain DSM 17307 / 273-4)
Taxonomic identifieri259536 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter
ProteomesiUP000000546: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 908908Translation initiation factor IF-2PRO_0000228233Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi259536.Psyc_0069.

Structurei

3D structure databases

ProteinModelPortaliQ4FVL5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini409 – 578170tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni418 – 4258G1By similarity
Regioni443 – 4475G2By similarity
Regioni464 – 4674G3By similarity
Regioni518 – 5214G4By similarity
Regioni554 – 5563G5By similarity

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076907.
KOiK02519.
OMAiHANTDVI.
OrthoDBiEOG67HJSV.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR009061. DNA-bd_dom_put.
IPR000795. EF_GTP-bd_dom.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4FVL5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADKTVKELA DMVSKTASAV QQQLVDAGLP ARAEGDLVTE LEQEKLVTYL
60 70 80 90 100
KQSHGQEEKR RISLKSKTTS TARVTGSSGK SKSVNVEVRK KKVFEKPDPE
110 120 130 140 150
KMAEELAARE QAMIESQARA AKDAEDRAAT KKKSEERQAA TLAAMRASLG
160 170 180 190 200
SSKKSDDKND DISTSVVVKK GGKTTIEVKP KEQPKKKVAA TKPKVETAVE
210 220 230 240 250
RKAREVREKE EARLREIETE TRRTQAEEAQ KRTLEQMRKM AGQYTDQPAT
260 270 280 290 300
EVRKDEPLAE GLVGDALEES FEKERREIKR GTSSTTARGR GRRKNQDERE
310 320 330 340 350
IKNRKNGLRS SQSAQHKFEK PVEKIVYDVE ISEQITVSDL AQRMAVKARE
360 370 380 390 400
VTKLLMKMGE IARESDTIDQ ATASLIVEEM GHNPVPVSDT KVEDDLQDAA
410 420 430 440 450
DERSSNVQTR PPVVTIMGHV DHGKTSLLDK IRETKVATGE AGGITQHIGA
460 470 480 490 500
YHVKTARGVI TFLDTPGHAA FSAMRSRGAQ ATDIVVLVVA ADDGMMPQTE
510 520 530 540 550
EAIDHARAAG TPLIVAINKM DKPSADPDRV LNELTAKEVV SEEWGGDTPM
560 570 580 590 600
ARISAKTGDG IDELLELISL QAELMELEAP LDGPAQGVVI ESRLEKGRGP
610 620 630 640 650
VVSVLVKKGT LKQGDLVLAG EHYGKVRAMT DEHGQRIQSA GPSIPVEILG
660 670 680 690 700
LPETPAAGSE FLVLTDEKKA REVADFRTNR ERERQLERQN AMRLESMFDQ
710 720 730 740 750
MEQGNVSYLN IVLKTDVRGS LEALLSALNE LSTDEVKVRV ISSGVGPISE
760 770 780 790 800
SDVTLAESSE AVLLGFNVRA DATARRKSDT ANMDIRYYSV IYGLIDDVKA
810 820 830 840 850
AMSGMLAPEH REKILGVADV REVFRSSKFG AAAGCMVVEG TIYRNKPIRV
860 870 880 890 900
LRNDQVIFTG QLQSLRRYKE DVNEVRTGME CGLAVRGYDV EAGDKIEVFE

IQEFARTI
Length:908
Mass (Da):99,875
Last modified:August 30, 2005 - v1
Checksum:i7B5B55166A0CB41C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000082 Genomic DNA. Translation: AAZ17943.1.
RefSeqiYP_263377.1. NC_007204.1.

Genome annotation databases

EnsemblBacteriaiAAZ17943; AAZ17943; Psyc_0069.
GeneIDi3514157.
KEGGipar:Psyc_0069.
PATRICi23054275. VBIPsyArc98534_0082.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000082 Genomic DNA. Translation: AAZ17943.1 .
RefSeqi YP_263377.1. NC_007204.1.

3D structure databases

ProteinModelPortali Q4FVL5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 259536.Psyc_0069.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ17943 ; AAZ17943 ; Psyc_0069 .
GeneIDi 3514157.
KEGGi par:Psyc_0069.
PATRICi 23054275. VBIPsyArc98534_0082.

Phylogenomic databases

eggNOGi COG0532.
HOGENOMi HOG000076907.
KOi K02519.
OMAi HANTDVI.
OrthoDBi EOG67HJSV.

Enzyme and pathway databases

BioCyci PARC259536:GI3A-71-MONOMER.

Family and domain databases

Gene3Di 3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00100_B. IF_2_B.
InterProi IPR009061. DNA-bd_dom_put.
IPR000795. EF_GTP-bd_dom.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view ]
PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 1 hit.
[Graphical view ]
SUPFAMi SSF46955. SSF46955. 1 hit.
SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Psychrobacter arcticus 273-4, a psychroactive Siberian permafrost bacterium, reveals mechanisms for adaptation to low-temperature growth."
    Ayala-del-Rio H.L., Chain P.S., Grzymski J.J., Ponder M.A., Ivanova N., Bergholz P.W., Di Bartolo G., Hauser L., Land M., Bakermans C., Rodrigues D., Klappenbach J., Zarka D., Larimer F., Richardson P., Murray A., Thomashow M., Tiedje J.M.
    Appl. Environ. Microbiol. 76:2304-2312(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17307 / 273-4.

Entry informationi

Entry nameiIF2_PSYA2
AccessioniPrimary (citable) accession number: Q4FVL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: August 30, 2005
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3