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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Psychrobacter arcticus (strain DSM 17307 / 273-4)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi418 – 425GTPUniRule annotation8
Nucleotide bindingi464 – 468GTPUniRule annotation5
Nucleotide bindingi518 – 521GTPUniRule annotation4

GO - Molecular functioni

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPARC259536:PSYC_RS00365-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:Psyc_0069
OrganismiPsychrobacter arcticus (strain DSM 17307 / 273-4)
Taxonomic identifieri259536 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter
Proteomesi
  • UP000000546 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002282331 – 908Translation initiation factor IF-2Add BLAST908

Proteomic databases

PRIDEiQ4FVL5

Interactioni

Protein-protein interaction databases

STRINGi259536.Psyc_0069

Structurei

3D structure databases

ProteinModelPortaliQ4FVL5
SMRiQ4FVL5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini409 – 578tr-type GAdd BLAST170

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni418 – 425G1By similarity8
Regioni443 – 447G2By similarity5
Regioni464 – 467G3By similarity4
Regioni518 – 521G4By similarity4
Regioni554 – 556G5By similarity3

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QHU Bacteria
COG0532 LUCA
HOGENOMiHOG000076907
KOiK02519
OMAiDNRTGGY
OrthoDBiPOG091H00EY

Family and domain databases

Gene3Di3.40.50.10050, 1 hit
HAMAPiMF_00100_B IF_2_B, 1 hit
InterProiView protein in InterPro
IPR009061 DNA-bd_dom_put_sf
IPR013575 IF2_assoc_dom_bac
IPR006847 IF2_N
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR000795 TF_GTP-bd_dom
IPR000178 TF_IF2_bacterial-like
IPR015760 TIF_IF2
IPR023115 TIF_IF2_dom3
IPR036925 TIF_IF2_dom3_sf
IPR009000 Transl_B-barrel_sf
PANTHERiPTHR43381 PTHR43381, 1 hit
PfamiView protein in Pfam
PF00009 GTP_EFTU, 1 hit
PF11987 IF-2, 1 hit
PF08364 IF2_assoc, 1 hit
PF04760 IF2_N, 1 hit
SUPFAMiSSF46955 SSF46955, 1 hit
SSF50447 SSF50447, 2 hits
SSF52156 SSF52156, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00487 IF-2, 1 hit
TIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51722 G_TR_2, 1 hit
PS01176 IF2, 1 hit

Sequencei

Sequence statusi: Complete.

Q4FVL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADKTVKELA DMVSKTASAV QQQLVDAGLP ARAEGDLVTE LEQEKLVTYL
60 70 80 90 100
KQSHGQEEKR RISLKSKTTS TARVTGSSGK SKSVNVEVRK KKVFEKPDPE
110 120 130 140 150
KMAEELAARE QAMIESQARA AKDAEDRAAT KKKSEERQAA TLAAMRASLG
160 170 180 190 200
SSKKSDDKND DISTSVVVKK GGKTTIEVKP KEQPKKKVAA TKPKVETAVE
210 220 230 240 250
RKAREVREKE EARLREIETE TRRTQAEEAQ KRTLEQMRKM AGQYTDQPAT
260 270 280 290 300
EVRKDEPLAE GLVGDALEES FEKERREIKR GTSSTTARGR GRRKNQDERE
310 320 330 340 350
IKNRKNGLRS SQSAQHKFEK PVEKIVYDVE ISEQITVSDL AQRMAVKARE
360 370 380 390 400
VTKLLMKMGE IARESDTIDQ ATASLIVEEM GHNPVPVSDT KVEDDLQDAA
410 420 430 440 450
DERSSNVQTR PPVVTIMGHV DHGKTSLLDK IRETKVATGE AGGITQHIGA
460 470 480 490 500
YHVKTARGVI TFLDTPGHAA FSAMRSRGAQ ATDIVVLVVA ADDGMMPQTE
510 520 530 540 550
EAIDHARAAG TPLIVAINKM DKPSADPDRV LNELTAKEVV SEEWGGDTPM
560 570 580 590 600
ARISAKTGDG IDELLELISL QAELMELEAP LDGPAQGVVI ESRLEKGRGP
610 620 630 640 650
VVSVLVKKGT LKQGDLVLAG EHYGKVRAMT DEHGQRIQSA GPSIPVEILG
660 670 680 690 700
LPETPAAGSE FLVLTDEKKA REVADFRTNR ERERQLERQN AMRLESMFDQ
710 720 730 740 750
MEQGNVSYLN IVLKTDVRGS LEALLSALNE LSTDEVKVRV ISSGVGPISE
760 770 780 790 800
SDVTLAESSE AVLLGFNVRA DATARRKSDT ANMDIRYYSV IYGLIDDVKA
810 820 830 840 850
AMSGMLAPEH REKILGVADV REVFRSSKFG AAAGCMVVEG TIYRNKPIRV
860 870 880 890 900
LRNDQVIFTG QLQSLRRYKE DVNEVRTGME CGLAVRGYDV EAGDKIEVFE

IQEFARTI
Length:908
Mass (Da):99,875
Last modified:August 30, 2005 - v1
Checksum:i7B5B55166A0CB41C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000082 Genomic DNA Translation: AAZ17943.1
RefSeqiWP_011279382.1, NC_007204.1

Genome annotation databases

EnsemblBacteriaiAAZ17943; AAZ17943; Psyc_0069
KEGGipar:Psyc_0069

Similar proteinsi

Entry informationi

Entry nameiIF2_PSYA2
AccessioniPrimary (citable) accession number: Q4FVL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: August 30, 2005
Last modified: June 20, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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