Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Argininosuccinate lyase

Gene

argH

Organism
Psychrobacter arcticus (strain DSM 17307 / 273-4)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. argininosuccinate lyase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process via ornithine Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

BioCyciPARC259536:GI3A-90-MONOMER.
UniPathwayiUPA00068; UER00114.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotation (EC:4.3.2.1UniRule annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotation
Ordered Locus Names:Psyc_0088
OrganismiPsychrobacter arcticus (strain DSM 17307 / 273-4)
Taxonomic identifieri259536 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter
ProteomesiUP000000546: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457Argininosuccinate lyasePRO_0000240756Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi259536.Psyc_0088.

Structurei

3D structure databases

ProteinModelPortaliQ4FVJ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0165.
HOGENOMiHOG000242744.
KOiK01755.
OMAiATDFRLW.
OrthoDBiEOG6P5ZF8.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
HAMAPiMF_00006. Arg_succ_lyase.
InterProiIPR029419. Arg_succ_lyase_C.
IPR009049. Argininosuccinate_lyase.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PTHR11444:SF3. PTHR11444:SF3. 1 hit.
PfamiPF14698. ASL_C2. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00838. argH. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4FVJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWGGRFSEAT DSFVAAFTAS VGFDQRFARH DIQGSIAHAT MLKECSILEA
60 70 80 90 100
DDVATIIDGL QQVLREIEAG EFNWSIALED VHMNVESRLT DIVGAVGKKL
110 120 130 140 150
HTGRSRNDQV ATDIRLWLRE ETDNIIALLV RLQSGLLDLA EQHTDTIMPG
160 170 180 190 200
FTHLQTAQPV SFGHHVMAWF EMLYRDTERL VDARRRINQM PLGSAALAGT
210 220 230 240 250
TFPIDRTITA ELLGFEGICQ NSLDAVSDRD FAIEFTSAAS ILMMHMSRMS
260 270 280 290 300
EEIILWMSAQ FNFVQIPDRF CTGSSIMPQK KNPDVPELVR GKAARVFGQL
310 320 330 340 350
MTLLSLMKSQ PLAYNKDNQE DKEPLFDCVD TLTGSLLAFA DMLPNITPNK
360 370 380 390 400
ENMRAATMKG YATATDLADY LVRNGVAFRD AHEVVGNAVA LGIKEGVDLS
410 420 430 440 450
DLSLAQLQQF SNAIGDDVFD FLTLEGSLAA RDHLGGTAPN QVKQAISRGR

TRLEVFA
Length:457
Mass (Da):50,505
Last modified:August 30, 2005 - v1
Checksum:iE87F69B91809F9C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000082 Genomic DNA. Translation: AAZ17962.1.
RefSeqiYP_263396.1. NC_007204.1.

Genome annotation databases

EnsemblBacteriaiAAZ17962; AAZ17962; Psyc_0088.
GeneIDi3514676.
KEGGipar:Psyc_0088.
PATRICi23054319. VBIPsyArc98534_0104.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000082 Genomic DNA. Translation: AAZ17962.1.
RefSeqiYP_263396.1. NC_007204.1.

3D structure databases

ProteinModelPortaliQ4FVJ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi259536.Psyc_0088.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAZ17962; AAZ17962; Psyc_0088.
GeneIDi3514676.
KEGGipar:Psyc_0088.
PATRICi23054319. VBIPsyArc98534_0104.

Phylogenomic databases

eggNOGiCOG0165.
HOGENOMiHOG000242744.
KOiK01755.
OMAiATDFRLW.
OrthoDBiEOG6P5ZF8.

Enzyme and pathway databases

UniPathwayiUPA00068; UER00114.
BioCyciPARC259536:GI3A-90-MONOMER.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
HAMAPiMF_00006. Arg_succ_lyase.
InterProiIPR029419. Arg_succ_lyase_C.
IPR009049. Argininosuccinate_lyase.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PTHR11444:SF3. PTHR11444:SF3. 1 hit.
PfamiPF14698. ASL_C2. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00838. argH. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Psychrobacter arcticus 273-4, a psychroactive Siberian permafrost bacterium, reveals mechanisms for adaptation to low-temperature growth."
    Ayala-del-Rio H.L., Chain P.S., Grzymski J.J., Ponder M.A., Ivanova N., Bergholz P.W., Di Bartolo G., Hauser L., Land M., Bakermans C., Rodrigues D., Klappenbach J., Zarka D., Larimer F., Richardson P., Murray A., Thomashow M., Tiedje J.M.
    Appl. Environ. Microbiol. 76:2304-2312(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17307 / 273-4.

Entry informationi

Entry nameiARLY_PSYA2
AccessioniPrimary (citable) accession number: Q4FVJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: August 30, 2005
Last modified: February 4, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.