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Q4FVJ6 (ARLY_PSYA2) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Argininosuccinate lyase

Short name=ASAL
EC=4.3.2.1
Alternative name(s):
Arginosuccinase
Gene names
Name:argH
Ordered Locus Names:Psyc_0088
OrganismPsychrobacter arcticus (strain DSM 17307 / 273-4) [Complete proteome] [HAMAP]
Taxonomic identifier259536 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter

Protein attributes

Sequence length457 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP-Rule MF_00006

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP-Rule MF_00006

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00006.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionargininosuccinate lyase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 457457Argininosuccinate lyase HAMAP-Rule MF_00006
PRO_0000240756

Sequences

Sequence LengthMass (Da)Tools
Q4FVJ6 [UniParc].

Last modified August 30, 2005. Version 1.
Checksum: E87F69B91809F9C1

FASTA45750,505
        10         20         30         40         50         60 
MWGGRFSEAT DSFVAAFTAS VGFDQRFARH DIQGSIAHAT MLKECSILEA DDVATIIDGL 

        70         80         90        100        110        120 
QQVLREIEAG EFNWSIALED VHMNVESRLT DIVGAVGKKL HTGRSRNDQV ATDIRLWLRE 

       130        140        150        160        170        180 
ETDNIIALLV RLQSGLLDLA EQHTDTIMPG FTHLQTAQPV SFGHHVMAWF EMLYRDTERL 

       190        200        210        220        230        240 
VDARRRINQM PLGSAALAGT TFPIDRTITA ELLGFEGICQ NSLDAVSDRD FAIEFTSAAS 

       250        260        270        280        290        300 
ILMMHMSRMS EEIILWMSAQ FNFVQIPDRF CTGSSIMPQK KNPDVPELVR GKAARVFGQL 

       310        320        330        340        350        360 
MTLLSLMKSQ PLAYNKDNQE DKEPLFDCVD TLTGSLLAFA DMLPNITPNK ENMRAATMKG 

       370        380        390        400        410        420 
YATATDLADY LVRNGVAFRD AHEVVGNAVA LGIKEGVDLS DLSLAQLQQF SNAIGDDVFD 

       430        440        450 
FLTLEGSLAA RDHLGGTAPN QVKQAISRGR TRLEVFA 

« Hide

References

[1]"The genome sequence of Psychrobacter arcticus 273-4, a psychroactive Siberian permafrost bacterium, reveals mechanisms for adaptation to low-temperature growth."
Ayala-del-Rio H.L., Chain P.S., Grzymski J.J., Ponder M.A., Ivanova N., Bergholz P.W., Di Bartolo G., Hauser L., Land M., Bakermans C., Rodrigues D., Klappenbach J., Zarka D., Larimer F., Richardson P., Murray A., Thomashow M., Tiedje J.M.
Appl. Environ. Microbiol. 76:2304-2312(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 17307 / 273-4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000082 Genomic DNA. Translation: AAZ17962.1.
RefSeqYP_263396.1. NC_007204.1.

3D structure databases

ProteinModelPortalQ4FVJ6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING259536.Psyc_0088.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAZ17962; AAZ17962; Psyc_0088.
GeneID3514676.
KEGGpar:Psyc_0088.
PATRIC23054319. VBIPsyArc98534_0104.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0165.
HOGENOMHOG000242744.
KOK01755.
OMAKEGIFDA.
OrthoDBEOG6P5ZF8.

Enzyme and pathway databases

BioCycPARC259536:GI3A-90-MONOMER.
UniPathwayUPA00068; UER00114.

Family and domain databases

Gene3D1.10.275.10. 1 hit.
HAMAPMF_00006. Arg_succ_lyase.
InterProIPR029419. Arg_succ_lyase_C.
IPR009049. Argininosuccinate_lyase.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERPTHR11444. PTHR11444. 1 hit.
PTHR11444:SF3. PTHR11444:SF3. 1 hit.
PfamPF14698. ASL_C2. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00149. FUMRATELYASE.
SUPFAMSSF48557. SSF48557. 1 hit.
TIGRFAMsTIGR00838. argH. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARLY_PSYA2
AccessionPrimary (citable) accession number: Q4FVJ6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: August 30, 2005
Last modified: June 11, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways