Q4FVE5 (AROE_PSYA2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	Psyc_0139

Organism

Psychrobacter arcticus (strain DSM 17307 / 273-4) [Complete proteome] [HAMAP]

Taxonomic identifier

259536 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Psychrobacter

Protein attributes

Sequence length	288 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 288	288	Shikimate dehydrogenase HAMAP MF_00222		PRO_0000325152
Regions
	Nucleotide binding	141 – 145	5	NADP By similarity
Sites
	Active site	68	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q4FVE5 [UniParc]. Last modified August 30, 2005. Version 1. Checksum: 399012D3AD584CF0	FASTA	288	30,240
	10 20 30 40 50 60 MTQHFIVIGN PIAHSKSPEI HTLFGAHAGL DICYQCQYCP DDPASFTAVI EAFFHGGGVG 70 80 90 100 110 120 ANVTVPFKQV AYECCAARGG LSEHAKIAGA VNTLSLNQAL LASGVSRAEA LYGDNTDGQG 130 140 150 160 170 180 LVNHMQRLGW PLNGARIAII GAGGAARGVV LPLIEAGIEA LTIANRTLSK ATELVNELST 190 200 210 220 230 240 ASVVIHNQQI QTCCTADLSG DFDIIVNATS IGLSGETLPL ADELNCQYAY DMMYGRELPF 250 260 270 280 LQHFAARGAQ TSDGYGMLIG QAALSFECWT GHAIDVTQAT AALEKSSI

References

[1]

"The genome sequence of Psychrobacter arcticus 273-4, a psychroactive Siberian permafrost bacterium, reveals mechanisms for adaptation to low-temperature growth." Ayala-del-Rio H.L., Chain P.S., Grzymski J.J., Ponder M.A., Ivanova N., Bergholz P.W., Di Bartolo G., Hauser L., Land M., Bakermans C., Rodrigues D., Klappenbach J., Zarka D., Larimer F., Richardson P., Murray A., Thomashow M., Tiedje J.M. Appl. Environ. Microbiol. 76:2304-2312(2010) [PubMed: 20154119] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 17307 / 273-4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000082 Genomic DNA. Translation: AAZ18013.1.
RefSeq	YP_263447.1. NC_007204.1.
3D structure databases
HSSP	HSSP built from PDB template 2GPT based on UniProtKB Q9SQT8.
ProteinModelPortal	Q4FVE5.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4FVE5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3514505.
GenomeReviews	Gene locus Psyc_0139 in contig CP000082_GR.
KEGG	par:Psyc_0139.
NMPDR	fig|259536.4.peg.331.
PATRIC	23054443. VBIPsyArc98534_0166.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0169.
HOGENOM	HBG553408.
OMA	VVFGNPI.
PhylomeDB	Q4FVE5.
ProtClustDB	CLSK838830.
Enzyme and pathway databases
BioCyc	PARC259536:PSYC_0139-MONOMER.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_PSYA2

Accession

Primary (citable) accession number: Q4FVE5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	August 30, 2005
Last modified:	January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program