Q4FVA1 (ACSA_PSYA2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetyl-coenzyme A synthetase
EC=6.2.1.1

Alternative name(s):
Acetate--CoA ligase
Acyl-activating enzyme

Gene names

Name:	acsA
Ordered Locus Names:	Psyc_0184

Organism

Psychrobacter arcticus (strain DSM 17307 / 273-4) [Complete proteome] [HAMAP]

Taxonomic identifier

259536 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Psychrobacter

Protein attributes

Sequence length	653 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123
Post-translational modification	Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
PTM	Acetylation
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 653	653	Acetyl-coenzyme A synthetase HAMAP MF_01123		PRO_1000137272
Sites
	Active site	519	1	By similarity
Amino acid modifications
	Modified residue	611	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4FVA1 [UniParc]. Last modified August 30, 2005. Version 1. Checksum: 66ADF5B698220AE0	FASTA	653	72,059
	10 20 30 40 50 60 MTQKSFPITP EFLAAANVTA EQYVEQYQQS IASPEATDAF WAKQAELIDW IKKPTKISDV 70 80 90 100 110 120 SYDLEDFRIK WFEDGELNIS VNCLDRHVKN NPYKPAIIWE GDHPSLHKII SFKELHEAVC 130 140 150 160 170 180 RLGNAMRKLG VKKGDRVTLY MPMIPEAVVA MLACTRIGAV HSVVFGGFST QSLGNRIIDS 190 200 210 220 230 240 QSKLVITADE GIRGNKRTPL KANVDRALDM DGTDSVSNVI VVHRTGNSVP MSGRRDIWYH 250 260 270 280 290 300 SLVDGESQYC EPEVMNAEDP LFLLYTSGST GKPKGVLHTT GGYITYALST FRDVFDVKDD 310 320 330 340 350 360 DVYWCTADVG WVTGHTYATY APLANGTTTV MFEGVPEYPT WARIGHIIDK HQITVLYTAP 370 380 390 400 410 420 TAIRAMMKEG DTFVRESDRS SLRLLGTVGE PINPEAWDWY YHIVGGGKCP VVDTWWQTET 430 440 450 460 470 480 GGIMLAPIPG TVAMKPGAVM NPLYGIIPEV IDTDGVALEG AAEGNLVING SWPGQMRTIY 490 500 510 520 530 540 KDHARFLETY FTEYPGYYFT GDGVQRDEDG HYWITGRVDD VLNVSGHRLG TAEIESAIVA 550 560 570 580 590 600 HPATAEAAVV GMPHDIRGIG ICAFVILKSS ETATESLKAE LNRHVRTEIG PIANLDAIYM 610 620 630 640 650 VNVLPKTRSG KIMRRILRSL AAGQYVGLGD LSTLADSSVI NELVEVVKTE RAK

References

[1]

"The genome sequence of Psychrobacter arcticus 273-4, a psychroactive Siberian permafrost bacterium, reveals mechanisms for adaptation to low-temperature growth." Ayala-del-Rio H.L., Chain P.S., Grzymski J.J., Ponder M.A., Ivanova N., Bergholz P.W., Di Bartolo G., Hauser L., Land M., Bakermans C., Rodrigues D., Klappenbach J., Zarka D., Larimer F., Richardson P., Murray A., Thomashow M., Tiedje J.M. Appl. Environ. Microbiol. 76:2304-2312(2010) [PubMed: 20154119] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 17307 / 273-4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000082 Genomic DNA. Translation: AAZ18057.1.
RefSeq	YP_263491.1. NC_007204.1.
3D structure databases
ProteinModelPortal	Q4FVA1.
SMR	Q4FVA1. Positions 7-648.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4FVA1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3514221.
GenomeReviews	Gene locus Psyc_0184 in contig CP000082_GR.
KEGG	par:Psyc_0184.
NMPDR	fig|259536.4.peg.347.
PATRIC	23054561. VBIPsyArc98534_0221.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0365.
HOGENOM	HBG547964.
OMA	KGKPYML.
PhylomeDB	Q4FVA1.
ProtClustDB	PRK00174.
Enzyme and pathway databases
BioCyc	PARC259536:PSYC_0184-MONOMER.
Family and domain databases
HAMAP	MF_01123. Ac_CoA_synth. [Tree]
InterPro	IPR011904. Ac_CoA_lig. IPR024597. Acyl-CoA_synth_DUF3448. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
KO	K01895.
PANTHER	PTHR24095:SF42. PTHR24095:SF42. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF11930. DUF3448. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACSA_PSYA2

Accession

Primary (citable) accession number: Q4FVA1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	August 30, 2005
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program