Q4FUA5 (PYRB_PSYA2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	Psyc_0542

Organism

Psychrobacter arcticus (strain DSM 17307 / 273-4) [Complete proteome] [HAMAP]

Taxonomic identifier

259536 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Psychrobacter

Protein attributes

Sequence length	357 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 357	357	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000329113

Sequences

	Sequence		Length	Mass (Da)
	Q4FUA5 [UniParc]. Last modified August 30, 2005. Version 1. Checksum: E27BD15E28132C74	FASTA	357	39,238
	10 20 30 40 50 60 MSNSIDSQSI PTISPTDYTK FDPDTIHEKL DASLSRPQLN TDGSIRHFLG IEGLNKAQLR 70 80 90 100 110 120 AIIAKAETFF DDKGQLINRP ELEGYTVMNL FFEPSTRTRT TFEVAEKRLG ANVLNIDIER 130 140 150 160 170 180 SSTKKGESLR DTLWNLQAMT ADIFVVRHSA SGAAHFMATE VTPDIAIING GDGWHAHPTQ 190 200 210 220 230 240 GMLDMLTIHR EAPRPFEELS VAIVGDIKHS RVARSDISAL QTLGVKDIRV CAPRTLLPKG 250 260 270 280 290 300 IERFGVQVYE NMNECVTDCD VIMGLRIQNE RIGSPLLASS SEYYKHYGIT PERMALAKPD 310 320 330 340 350 AFVMHPGPMN RGVEIASSVA DGAQSVILKQ VNNGIAIRMA VLSLAMEGQR AHQAAGN

References

[1]

"The genome sequence of Psychrobacter arcticus 273-4, a psychroactive Siberian permafrost bacterium, reveals mechanisms for adaptation to low-temperature growth." Ayala-del-Rio H.L., Chain P.S., Grzymski J.J., Ponder M.A., Ivanova N., Bergholz P.W., Di Bartolo G., Hauser L., Land M., Bakermans C., Rodrigues D., Klappenbach J., Zarka D., Larimer F., Richardson P., Murray A., Thomashow M., Tiedje J.M. Appl. Environ. Microbiol. 76:2304-2312(2010) [PubMed: 20154119] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 17307 / 273-4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000082 Genomic DNA. Translation: AAZ18403.1.
RefSeq	YP_263837.1. NC_007204.1.
3D structure databases
HSSP	HSSP built from PDB template 2AIR based on UniProtKB P0A786.
ProteinModelPortal	Q4FUA5.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4FUA5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3513969.
GenomeReviews	Gene locus Psyc_0542 in contig CP000082_GR.
KEGG	par:Psyc_0542.
NMPDR	fig|259536.4.peg.255.
PATRIC	23055451. VBIPsyArc98534_0656.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0540.
HOGENOM	HBG579429.
OMA	VGIPIIN.
PhylomeDB	Q4FUA5.
ProtClustDB	PRK00856.
Enzyme and pathway databases
BioCyc	PARC259536:PSYC_0542-MONOMER.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_PSYA2

Accession

Primary (citable) accession number: Q4FUA5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	August 30, 2005
Last modified:	January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program