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Q4FU71

- SYL_PSYA2

UniProt

Q4FU71 - SYL_PSYA2

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Psychrobacter arcticus (strain DSM 17307 / 273-4)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (30 Aug 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei670 – 6701ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPARC259536:GI3A-600-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Psyc_0576
    OrganismiPsychrobacter arcticus (strain DSM 17307 / 273-4)
    Taxonomic identifieri259536 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter
    ProteomesiUP000000546: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 921921Leucine--tRNA ligasePRO_0000334797Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi259536.Psyc_0576.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4FU71.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi80 – 9011"HIGH" regionAdd
    BLAST
    Motifi667 – 6715"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiMAFAGPP.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4FU71-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLWHYKISPH LSVITNSEPT MSNAVTAETA NTNNTSIENA QYQPQLIEAA    50
    QQAKWATDKR FEVSNEPSDK PSRYMLSMFP YPSGKLHMGH VRNYTISDVL 100
    SRYYRLKGYE VMQPMGWDGF GLPAENAAIA NQTPPAKWTF ENIDSMRAQL 150
    KLLGLSIDWS REFATCSPEY YQWEQWLFLQ LYKKGLVYKK LATVNWDPID 200
    NTVLANEQVI DGKGWRSGAM VEKRDIPMYY FNITDYADEL LDDLDQLEGH 250
    WPSEVITMQR NWIGRSSGME VHFPYELAGE SNSLDVFTTR PDTLMGVTYV 300
    AVAAEHPLAQ YASEHNEAIA AFCALCKKGS VAEADLAKAE KVGIDTGLTV 350
    THPLTGEEVP VWVANYVLMS YGSGAVMAVP AHDERDYEFA TKYSLPIKQV 400
    IDIPARYFDD IEEGNDNRAY TERNTLVNSG EFDGMDFEQA FAAMLAKLEP 450
    QSLAKKKIQY RLRDWGVSRQ RYWGCPIPMV NCEHCGTVPV EEQDLPVILP 500
    TDVVPDGRGN PLKNIPEFVN TTCPKCGNPA ERETDTFDTF VESSWYYARF 550
    ASPNDTTNMV NKSAANKWLP VDQYIGGVEH AVMHLLYARF FHKLMRDENL 600
    VSGDEPFANL MTQGMVLAGT FYRVNPDGST TYYFTKDIDI DFNERGQPIK 650
    AILKSDGQPV TIGKIEKMSK SKNNGVDPQI TIDKYGADTV RLYTLFTAPA 700
    DQTLEWSDDA LKGPYNFVKK VWRIASEHMQ ALTAANLSLD TLNNGTLNND 750
    ALNTEGLSKE AKALRRKTHE TIGKIDSDLG KRLALNTPVS SLMELANELS 800
    NFKANSEQEL QVQHEALIDL LIMLSVYAPH IGEHLLEQLG LDTVTLNYPA 850
    VDESALVQDM ITMVIQVNGK MRGKMDVAPN SDPEALKAQA RAIEGVAKFL 900
    TGEIKKEIVV PNKLVNIVVA G 921
    Length:921
    Mass (Da):103,244
    Last modified:August 30, 2005 - v1
    Checksum:iA3E4AA9983B25748
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000082 Genomic DNA. Translation: AAZ18437.1.
    RefSeqiYP_263871.1. NC_007204.1.

    Genome annotation databases

    EnsemblBacteriaiAAZ18437; AAZ18437; Psyc_0576.
    GeneIDi3514464.
    KEGGipar:Psyc_0576.
    PATRICi23055543. VBIPsyArc98534_0695.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000082 Genomic DNA. Translation: AAZ18437.1 .
    RefSeqi YP_263871.1. NC_007204.1.

    3D structure databases

    ProteinModelPortali Q4FU71.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 259536.Psyc_0576.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ18437 ; AAZ18437 ; Psyc_0576 .
    GeneIDi 3514464.
    KEGGi par:Psyc_0576.
    PATRICi 23055543. VBIPsyArc98534_0695.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi MAFAGPP.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci PARC259536:GI3A-600-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Psychrobacter arcticus 273-4, a psychroactive Siberian permafrost bacterium, reveals mechanisms for adaptation to low-temperature growth."
      Ayala-del-Rio H.L., Chain P.S., Grzymski J.J., Ponder M.A., Ivanova N., Bergholz P.W., Di Bartolo G., Hauser L., Land M., Bakermans C., Rodrigues D., Klappenbach J., Zarka D., Larimer F., Richardson P., Murray A., Thomashow M., Tiedje J.M.
      Appl. Environ. Microbiol. 76:2304-2312(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 17307 / 273-4.

    Entry informationi

    Entry nameiSYL_PSYA2
    AccessioniPrimary (citable) accession number: Q4FU71
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: August 30, 2005
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3