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Q4FU71

- SYL_PSYA2

UniProt

Q4FU71 - SYL_PSYA2

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Psychrobacter arcticus (strain DSM 17307 / 273-4)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei670 – 6701ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPARC259536:GI3A-600-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Psyc_0576
OrganismiPsychrobacter arcticus (strain DSM 17307 / 273-4)
Taxonomic identifieri259536 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter
ProteomesiUP000000546: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 921921Leucine--tRNA ligasePRO_0000334797Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi259536.Psyc_0576.

Structurei

3D structure databases

ProteinModelPortaliQ4FU71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi80 – 9011"HIGH" regionAdd
BLAST
Motifi667 – 6715"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiMAFAGPP.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4FU71-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLWHYKISPH LSVITNSEPT MSNAVTAETA NTNNTSIENA QYQPQLIEAA
60 70 80 90 100
QQAKWATDKR FEVSNEPSDK PSRYMLSMFP YPSGKLHMGH VRNYTISDVL
110 120 130 140 150
SRYYRLKGYE VMQPMGWDGF GLPAENAAIA NQTPPAKWTF ENIDSMRAQL
160 170 180 190 200
KLLGLSIDWS REFATCSPEY YQWEQWLFLQ LYKKGLVYKK LATVNWDPID
210 220 230 240 250
NTVLANEQVI DGKGWRSGAM VEKRDIPMYY FNITDYADEL LDDLDQLEGH
260 270 280 290 300
WPSEVITMQR NWIGRSSGME VHFPYELAGE SNSLDVFTTR PDTLMGVTYV
310 320 330 340 350
AVAAEHPLAQ YASEHNEAIA AFCALCKKGS VAEADLAKAE KVGIDTGLTV
360 370 380 390 400
THPLTGEEVP VWVANYVLMS YGSGAVMAVP AHDERDYEFA TKYSLPIKQV
410 420 430 440 450
IDIPARYFDD IEEGNDNRAY TERNTLVNSG EFDGMDFEQA FAAMLAKLEP
460 470 480 490 500
QSLAKKKIQY RLRDWGVSRQ RYWGCPIPMV NCEHCGTVPV EEQDLPVILP
510 520 530 540 550
TDVVPDGRGN PLKNIPEFVN TTCPKCGNPA ERETDTFDTF VESSWYYARF
560 570 580 590 600
ASPNDTTNMV NKSAANKWLP VDQYIGGVEH AVMHLLYARF FHKLMRDENL
610 620 630 640 650
VSGDEPFANL MTQGMVLAGT FYRVNPDGST TYYFTKDIDI DFNERGQPIK
660 670 680 690 700
AILKSDGQPV TIGKIEKMSK SKNNGVDPQI TIDKYGADTV RLYTLFTAPA
710 720 730 740 750
DQTLEWSDDA LKGPYNFVKK VWRIASEHMQ ALTAANLSLD TLNNGTLNND
760 770 780 790 800
ALNTEGLSKE AKALRRKTHE TIGKIDSDLG KRLALNTPVS SLMELANELS
810 820 830 840 850
NFKANSEQEL QVQHEALIDL LIMLSVYAPH IGEHLLEQLG LDTVTLNYPA
860 870 880 890 900
VDESALVQDM ITMVIQVNGK MRGKMDVAPN SDPEALKAQA RAIEGVAKFL
910 920
TGEIKKEIVV PNKLVNIVVA G
Length:921
Mass (Da):103,244
Last modified:August 30, 2005 - v1
Checksum:iA3E4AA9983B25748
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000082 Genomic DNA. Translation: AAZ18437.1.
RefSeqiYP_263871.1. NC_007204.1.

Genome annotation databases

EnsemblBacteriaiAAZ18437; AAZ18437; Psyc_0576.
GeneIDi3514464.
KEGGipar:Psyc_0576.
PATRICi23055543. VBIPsyArc98534_0695.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000082 Genomic DNA. Translation: AAZ18437.1 .
RefSeqi YP_263871.1. NC_007204.1.

3D structure databases

ProteinModelPortali Q4FU71.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 259536.Psyc_0576.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ18437 ; AAZ18437 ; Psyc_0576 .
GeneIDi 3514464.
KEGGi par:Psyc_0576.
PATRICi 23055543. VBIPsyArc98534_0695.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi MAFAGPP.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci PARC259536:GI3A-600-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Psychrobacter arcticus 273-4, a psychroactive Siberian permafrost bacterium, reveals mechanisms for adaptation to low-temperature growth."
    Ayala-del-Rio H.L., Chain P.S., Grzymski J.J., Ponder M.A., Ivanova N., Bergholz P.W., Di Bartolo G., Hauser L., Land M., Bakermans C., Rodrigues D., Klappenbach J., Zarka D., Larimer F., Richardson P., Murray A., Thomashow M., Tiedje J.M.
    Appl. Environ. Microbiol. 76:2304-2312(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17307 / 273-4.

Entry informationi

Entry nameiSYL_PSYA2
AccessioniPrimary (citable) accession number: Q4FU71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 30, 2005
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3