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Q4FTK9 (GCSP_PSYA2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:Psyc_0796
OrganismPsychrobacter arcticus (strain DSM 17307 / 273-4) [Complete proteome] [HAMAP]
Taxonomic identifier259536 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter

Protein attributes

Sequence length965 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 965965Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_0000227122

Amino acid modifications

Modified residue7111N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4FTK9 [UniParc].

Last modified August 30, 2005. Version 1.
Checksum: 9CC5BCC617624E50

FASTA965105,914
        10         20         30         40         50         60 
MTISQNPTLD TFKGLFNEAE FVYRHLGSND AKQADLLSAI GYKDMATFIN DTVPEPVRLH 

        70         80         90        100        110        120 
KELDLPVAMS EHAALAKLRT MADDITVNKS YIGQGYSPVR MPAVIQRNVL ENPGWYTAYT 

       130        140        150        160        170        180 
PYQAEIAQGR LEALLNFQQV CIDLTGLELA GASLLDEATA AAEAMAMSKR VSKSKSMQFF 

       190        200        210        220        230        240 
VDDRVYSQTL DVINTRAKYF GWEVVVGDFE LAKSGDYFGA LFQYVGVEGD VKDLTDVIAA 

       250        260        270        280        290        300 
VKKNKTYVNV VSDIMSLVLL KSPADMGADV ALGSTQRFGI PMGFGGPHAA YFAFSDKAKR 

       310        320        330        340        350        360 
SAPGRIIGVS KDSQGNTALR MALQTREQHI RREKANSNIC TSQVLLANLA GMYAVYHGPG 

       370        380        390        400        410        420 
GVKRIATRIH AFATAFADVI KNANDSNLNV VHDQFFDSVV IDCGSEKLAT QIFENADNVG 

       430        440        450        460        470        480 
YNLWRLGDSK LSVAFSETSD QEDFKILTQL FVTKAHDLPE DARISLDSTH LRTDDILTHP 

       490        500        510        520        530        540 
VFNSHHTEHE MLRYLKSLED KDLAMNRSMI SLGSCTMKLN ATSEMLPITW PEFANVHPFA 

       550        560        570        580        590        600 
PRDQVTGYVA MIDSLQEQLK AITGFDDVSM QPNSGASGEY AGLLAIRRYH ESLGETDRDV 

       610        620        630        640        650        660 
CLIPMSAHGT NPATAMMMGM KVVVVKTDDN GNVDIDDLTA KSEEHSARLG ALMITYPSTH 

       670        680        690        700        710        720 
GVFEEGIRKI CDLIHKHGGQ VYMDGANMNA QVGMMQPADV GADVLHMNLH KTFCIPHGGG 

       730        740        750        760        770        780 
GPGMGPIGMK SHLAPFMANH TLSPVHNAQK DCSAVSAAPY GSASILPISW MYIAMMGRDG 

       790        800        810        820        830        840 
LLKATELALL NANYVAAELK DYYPVLYTGK NGRVAHECII DIRPLKEETG ISESDIAKRL 

       850        860        870        880        890        900 
MDYGFHSPTM SFPVAGTLMI EPTESESKEE LDRFISALKS IKAEAMKAKA GEDNWTLENN 

       910        920        930        940        950        960 
PLVNAPHTAA MVIDGEWTYP YSRETAAFPL PYIRTNKFWP SVARVDDAYG DKNLMCSCPS 


IENYM 

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References

[1]"The genome sequence of Psychrobacter arcticus 273-4, a psychroactive Siberian permafrost bacterium, reveals mechanisms for adaptation to low-temperature growth."
Ayala-del-Rio H.L., Chain P.S., Grzymski J.J., Ponder M.A., Ivanova N., Bergholz P.W., Di Bartolo G., Hauser L., Land M., Bakermans C., Rodrigues D., Klappenbach J., Zarka D., Larimer F., Richardson P., Murray A., Thomashow M., Tiedje J.M.
Appl. Environ. Microbiol. 76:2304-2312(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 17307 / 273-4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000082 Genomic DNA. Translation: AAZ18649.1.
RefSeqYP_264083.1. NC_007204.1.

3D structure databases

ProteinModelPortalQ4FTK9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING259536.Psyc_0796.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAZ18649; AAZ18649; Psyc_0796.
GeneID3514644.
KEGGpar:Psyc_0796.
PATRIC23056049. VBIPsyArc98534_0945.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAFDSRPYS.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycPARC259536:GI3A-823-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_PSYA2
AccessionPrimary (citable) accession number: Q4FTK9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: August 30, 2005
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families