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Q4FTK9

- GCSP_PSYA2

UniProt

Q4FTK9 - GCSP_PSYA2

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Psychrobacter arcticus (strain DSM 17307 / 273-4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPARC259536:GI3A-823-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Psyc_0796
OrganismiPsychrobacter arcticus (strain DSM 17307 / 273-4)
Taxonomic identifieri259536 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter
ProteomesiUP000000546: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 965965Glycine dehydrogenase (decarboxylating)PRO_0000227122Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei711 – 7111N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi259536.Psyc_0796.

Structurei

3D structure databases

ProteinModelPortaliQ4FTK9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4FTK9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTISQNPTLD TFKGLFNEAE FVYRHLGSND AKQADLLSAI GYKDMATFIN
60 70 80 90 100
DTVPEPVRLH KELDLPVAMS EHAALAKLRT MADDITVNKS YIGQGYSPVR
110 120 130 140 150
MPAVIQRNVL ENPGWYTAYT PYQAEIAQGR LEALLNFQQV CIDLTGLELA
160 170 180 190 200
GASLLDEATA AAEAMAMSKR VSKSKSMQFF VDDRVYSQTL DVINTRAKYF
210 220 230 240 250
GWEVVVGDFE LAKSGDYFGA LFQYVGVEGD VKDLTDVIAA VKKNKTYVNV
260 270 280 290 300
VSDIMSLVLL KSPADMGADV ALGSTQRFGI PMGFGGPHAA YFAFSDKAKR
310 320 330 340 350
SAPGRIIGVS KDSQGNTALR MALQTREQHI RREKANSNIC TSQVLLANLA
360 370 380 390 400
GMYAVYHGPG GVKRIATRIH AFATAFADVI KNANDSNLNV VHDQFFDSVV
410 420 430 440 450
IDCGSEKLAT QIFENADNVG YNLWRLGDSK LSVAFSETSD QEDFKILTQL
460 470 480 490 500
FVTKAHDLPE DARISLDSTH LRTDDILTHP VFNSHHTEHE MLRYLKSLED
510 520 530 540 550
KDLAMNRSMI SLGSCTMKLN ATSEMLPITW PEFANVHPFA PRDQVTGYVA
560 570 580 590 600
MIDSLQEQLK AITGFDDVSM QPNSGASGEY AGLLAIRRYH ESLGETDRDV
610 620 630 640 650
CLIPMSAHGT NPATAMMMGM KVVVVKTDDN GNVDIDDLTA KSEEHSARLG
660 670 680 690 700
ALMITYPSTH GVFEEGIRKI CDLIHKHGGQ VYMDGANMNA QVGMMQPADV
710 720 730 740 750
GADVLHMNLH KTFCIPHGGG GPGMGPIGMK SHLAPFMANH TLSPVHNAQK
760 770 780 790 800
DCSAVSAAPY GSASILPISW MYIAMMGRDG LLKATELALL NANYVAAELK
810 820 830 840 850
DYYPVLYTGK NGRVAHECII DIRPLKEETG ISESDIAKRL MDYGFHSPTM
860 870 880 890 900
SFPVAGTLMI EPTESESKEE LDRFISALKS IKAEAMKAKA GEDNWTLENN
910 920 930 940 950
PLVNAPHTAA MVIDGEWTYP YSRETAAFPL PYIRTNKFWP SVARVDDAYG
960
DKNLMCSCPS IENYM
Length:965
Mass (Da):105,914
Last modified:August 30, 2005 - v1
Checksum:i9CC5BCC617624E50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000082 Genomic DNA. Translation: AAZ18649.1.
RefSeqiYP_264083.1. NC_007204.1.

Genome annotation databases

EnsemblBacteriaiAAZ18649; AAZ18649; Psyc_0796.
GeneIDi3514644.
KEGGipar:Psyc_0796.
PATRICi23056049. VBIPsyArc98534_0945.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000082 Genomic DNA. Translation: AAZ18649.1 .
RefSeqi YP_264083.1. NC_007204.1.

3D structure databases

ProteinModelPortali Q4FTK9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 259536.Psyc_0796.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ18649 ; AAZ18649 ; Psyc_0796 .
GeneIDi 3514644.
KEGGi par:Psyc_0796.
PATRICi 23056049. VBIPsyArc98534_0945.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci PARC259536:GI3A-823-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Psychrobacter arcticus 273-4, a psychroactive Siberian permafrost bacterium, reveals mechanisms for adaptation to low-temperature growth."
    Ayala-del-Rio H.L., Chain P.S., Grzymski J.J., Ponder M.A., Ivanova N., Bergholz P.W., Di Bartolo G., Hauser L., Land M., Bakermans C., Rodrigues D., Klappenbach J., Zarka D., Larimer F., Richardson P., Murray A., Thomashow M., Tiedje J.M.
    Appl. Environ. Microbiol. 76:2304-2312(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17307 / 273-4.

Entry informationi

Entry nameiGCSP_PSYA2
AccessioniPrimary (citable) accession number: Q4FTK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: August 30, 2005
Last modified: November 26, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3