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Q4FTK9

- GCSP_PSYA2

UniProt

Q4FTK9 - GCSP_PSYA2

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Psychrobacter arcticus (strain DSM 17307 / 273-4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (30 Aug 2005)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciPARC259536:GI3A-823-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:Psyc_0796
    OrganismiPsychrobacter arcticus (strain DSM 17307 / 273-4)
    Taxonomic identifieri259536 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter
    ProteomesiUP000000546: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 965965Glycine dehydrogenase (decarboxylating)PRO_0000227122Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei711 – 7111N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi259536.Psyc_0796.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4FTK9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q4FTK9-1 [UniParc]FASTAAdd to Basket

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    MTISQNPTLD TFKGLFNEAE FVYRHLGSND AKQADLLSAI GYKDMATFIN    50
    DTVPEPVRLH KELDLPVAMS EHAALAKLRT MADDITVNKS YIGQGYSPVR 100
    MPAVIQRNVL ENPGWYTAYT PYQAEIAQGR LEALLNFQQV CIDLTGLELA 150
    GASLLDEATA AAEAMAMSKR VSKSKSMQFF VDDRVYSQTL DVINTRAKYF 200
    GWEVVVGDFE LAKSGDYFGA LFQYVGVEGD VKDLTDVIAA VKKNKTYVNV 250
    VSDIMSLVLL KSPADMGADV ALGSTQRFGI PMGFGGPHAA YFAFSDKAKR 300
    SAPGRIIGVS KDSQGNTALR MALQTREQHI RREKANSNIC TSQVLLANLA 350
    GMYAVYHGPG GVKRIATRIH AFATAFADVI KNANDSNLNV VHDQFFDSVV 400
    IDCGSEKLAT QIFENADNVG YNLWRLGDSK LSVAFSETSD QEDFKILTQL 450
    FVTKAHDLPE DARISLDSTH LRTDDILTHP VFNSHHTEHE MLRYLKSLED 500
    KDLAMNRSMI SLGSCTMKLN ATSEMLPITW PEFANVHPFA PRDQVTGYVA 550
    MIDSLQEQLK AITGFDDVSM QPNSGASGEY AGLLAIRRYH ESLGETDRDV 600
    CLIPMSAHGT NPATAMMMGM KVVVVKTDDN GNVDIDDLTA KSEEHSARLG 650
    ALMITYPSTH GVFEEGIRKI CDLIHKHGGQ VYMDGANMNA QVGMMQPADV 700
    GADVLHMNLH KTFCIPHGGG GPGMGPIGMK SHLAPFMANH TLSPVHNAQK 750
    DCSAVSAAPY GSASILPISW MYIAMMGRDG LLKATELALL NANYVAAELK 800
    DYYPVLYTGK NGRVAHECII DIRPLKEETG ISESDIAKRL MDYGFHSPTM 850
    SFPVAGTLMI EPTESESKEE LDRFISALKS IKAEAMKAKA GEDNWTLENN 900
    PLVNAPHTAA MVIDGEWTYP YSRETAAFPL PYIRTNKFWP SVARVDDAYG 950
    DKNLMCSCPS IENYM 965
    Length:965
    Mass (Da):105,914
    Last modified:August 30, 2005 - v1
    Checksum:i9CC5BCC617624E50
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000082 Genomic DNA. Translation: AAZ18649.1.
    RefSeqiYP_264083.1. NC_007204.1.

    Genome annotation databases

    EnsemblBacteriaiAAZ18649; AAZ18649; Psyc_0796.
    GeneIDi3514644.
    KEGGipar:Psyc_0796.
    PATRICi23056049. VBIPsyArc98534_0945.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000082 Genomic DNA. Translation: AAZ18649.1 .
    RefSeqi YP_264083.1. NC_007204.1.

    3D structure databases

    ProteinModelPortali Q4FTK9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 259536.Psyc_0796.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ18649 ; AAZ18649 ; Psyc_0796 .
    GeneIDi 3514644.
    KEGGi par:Psyc_0796.
    PATRICi 23056049. VBIPsyArc98534_0945.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci PARC259536:GI3A-823-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Psychrobacter arcticus 273-4, a psychroactive Siberian permafrost bacterium, reveals mechanisms for adaptation to low-temperature growth."
      Ayala-del-Rio H.L., Chain P.S., Grzymski J.J., Ponder M.A., Ivanova N., Bergholz P.W., Di Bartolo G., Hauser L., Land M., Bakermans C., Rodrigues D., Klappenbach J., Zarka D., Larimer F., Richardson P., Murray A., Thomashow M., Tiedje J.M.
      Appl. Environ. Microbiol. 76:2304-2312(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 17307 / 273-4.

    Entry informationi

    Entry nameiGCSP_PSYA2
    AccessioniPrimary (citable) accession number: Q4FTK9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: August 30, 2005
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3