Reviewed, UniProtKB/Swiss-Prot Q4FSH2 (HIS81_PSYA2)

Names and origin

Protein names

Recommended name:
    Histidinol-phosphate aminotransferase 1
    EC=2.6.1.9
Alternative name(s):
    Imidazole acetol-phosphate transaminase 1

Gene names

Name:	hisC1
Ordered Locus Names:	Psyc_1185

Organism

Psychrobacter arcticus (strain DSM 17307 / 273-4) [Complete proteome] [HAMAP]

Taxonomic identifier

259536 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Psychrobacter

Protein attributes

Sequence length	380 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 380	380	Histidinol-phosphate aminotransferase 1 HAMAP MF_01023		PRO_0000153426
Amino acid modifications
	Modified residue	235	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4FSH2-1 [UniParc]. Last modified August 30, 2005. Version 1. Checksum: E2B3C8656D940EA6	FASTA	380	41,809
	10 20 30 40 50 60 MQSTQSTESN LLPLVPAYDS ILALAPYQTG KPIEELTREY GVSDVVKLAS NENPIGCSPH 70 80 90 100 110 120 VTLAITEQIG QLSRYPDGNG YYLKQALADF NDVNVDQITL GNGSDDLLDI LARSFVGADD 130 140 150 160 170 180 AIVYSQYAFV VYSMLAKMQG AMDVEVPAQR FGHDLKAMSQ AIENNSNTKI VFIANPNNPT 190 200 210 220 230 240 GTQLEHGELR EFVASVPSSV LVVLDEAYIE YSPESNNRAL LDEFDNVVIV RTFSKAYGLA 250 260 270 280 290 300 GLRVGYALSS AAVADLLNRI RQPFNVSRVA LAAAAAALAD QDFIEKTRLI NDEQMHWLEK 310 320 330 340 350 360 QFDALGLGFI KSHANFIMVE IAVEMEDTNA AVIYQALLEQ GVIVRQLEVY GLYNWLRISV 370 380 GVAEDNMRLI DTLRSILTDD

References

[1]

"Complete sequence of Psychrobacter arcticum 273-4." NASA Astrobiology Institute Ayala-del-Rio H.L., Chain P., Ponder M.A., Di Bartolo G., Ivanova N., Bergholz P.W., Hauser L., Land M., Bakermans C., Rodrigues D., Klappenbach J.A., Zarka D., Larimer F., Richardson P., Thomashow M.F., Tiedje J.M. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000082 Genomic DNA. Translation: AAZ19036.1.
RefSeq	YP_264470.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3514083.
GenomeReviews	Gene locus Psyc_1185 in contig CP000082_GR.
KEGG	par:Psyc_1185.
NMPDR	fig|259536.4.peg.788.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4FSH2.
OMA	Q4FSH2. KGYIVRS.
Enzyme and pathway databases
BioCyc	PARC259536:PSYC_1185-MON.
Family and domain databases
HAMAP	MF_01023. [Tree]
InterPro	IPR004839. Aminotrans_I/II. IPR001917. Aminotrans_II_pyridoxalP_BS. IPR005861. HisP_aminotrans. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01141. hisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS81_PSYA2

Accession

Primary (citable) accession number: Q4FSH2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	August 30, 2005
Last modified:	June 16, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)