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Protein

S-adenosylmethionine:tRNA ribosyltransferase-isomerase

Gene

queA

Organism
Psychrobacter arcticus (strain DSM 17307 / 273-4)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 7-aminomethyl-7-carbaguanosine(34) in tRNA = L-methionine + adenine + epoxyqueuosine(34) in tRNA.UniRule annotation

Pathwayi: tRNA-queuosine biosynthesis

This protein is involved in the pathway tRNA-queuosine biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tRNA-queuosine biosynthesis and in tRNA modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Queuosine biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00392.

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine:tRNA ribosyltransferase-isomeraseUniRule annotation (EC:2.4.99.17UniRule annotation)
Alternative name(s):
Queuosine biosynthesis protein QueAUniRule annotation
Gene namesi
Name:queAUniRule annotation
Ordered Locus Names:Psyc_1404
OrganismiPsychrobacter arcticus (strain DSM 17307 / 273-4)
Taxonomic identifieri259536 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter
Proteomesi
  • UP000000546 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002313621 – 403S-adenosylmethionine:tRNA ribosyltransferase-isomeraseAdd BLAST403

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi259536.Psyc_1404.

Structurei

3D structure databases

ProteinModelPortaliQ4FRV6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the QueA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E2N. Bacteria.
COG0809. LUCA.
HOGENOMiHOG000004401.
KOiK07568.
OMAiYGDAMFL.
OrthoDBiPOG091H00ZG.

Family and domain databases

HAMAPiMF_00113. QueA. 1 hit.
InterProiIPR003699. QueA.
[Graphical view]
PfamiPF02547. Queuosine_synth. 1 hit.
[Graphical view]
SUPFAMiSSF111337. SSF111337. 2 hits.
TIGRFAMsiTIGR00113. queA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4FRV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDSEPQTLN NNSEITANHN DDILEYLSVD DYDYELPDQL IARYPLAQRS
60 70 80 90 100
ASKLLYLPTN NANSQVEDKL FSELPDILNA GDLIVFNDTK VMKARLFGQK
110 120 130 140 150
DTGGKIEVLI ERLVSLSDVN SAYLDEIIAN SKTIDTTIIA EKHIALCHIK
160 170 180 190 200
ASKALKLGQG LVLADGHMTG IMIGRQENLF ILAFDTPILP DLEQYGELPI
210 220 230 240 250
PPYFERHADA TDNTRYQTVF HDPAKLASVA APTASLHFDD IVLEKLAAKG
260 270 280 290 300
IQTAFVTLHV GAGTFAPVKT DNLLNHTMHS EYAHLPQATA ELINQTHANG
310 320 330 340 350
KQVIAIGTTV TRVLETAYQQ TAVDGQSLSG WSGDTDIFIY PGFKFGVVDK
360 370 380 390 400
LLTNFHLPKS TLLMLVSAFA TKKSIEQAYQ HAIKSQYRFF SYGDAMLLDK

QVD
Length:403
Mass (Da):44,530
Last modified:August 30, 2005 - v1
Checksum:i954C4322295BF4DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000082 Genomic DNA. Translation: AAZ19252.1.
RefSeqiWP_011280673.1. NC_007204.1.

Genome annotation databases

EnsemblBacteriaiAAZ19252; AAZ19252; Psyc_1404.
KEGGipar:Psyc_1404.
PATRICi23057477. VBIPsyArc98534_1654.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000082 Genomic DNA. Translation: AAZ19252.1.
RefSeqiWP_011280673.1. NC_007204.1.

3D structure databases

ProteinModelPortaliQ4FRV6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi259536.Psyc_1404.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAZ19252; AAZ19252; Psyc_1404.
KEGGipar:Psyc_1404.
PATRICi23057477. VBIPsyArc98534_1654.

Phylogenomic databases

eggNOGiENOG4105E2N. Bacteria.
COG0809. LUCA.
HOGENOMiHOG000004401.
KOiK07568.
OMAiYGDAMFL.
OrthoDBiPOG091H00ZG.

Enzyme and pathway databases

UniPathwayiUPA00392.

Family and domain databases

HAMAPiMF_00113. QueA. 1 hit.
InterProiIPR003699. QueA.
[Graphical view]
PfamiPF02547. Queuosine_synth. 1 hit.
[Graphical view]
SUPFAMiSSF111337. SSF111337. 2 hits.
TIGRFAMsiTIGR00113. queA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQUEA_PSYA2
AccessioniPrimary (citable) accession number: Q4FRV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: August 30, 2005
Last modified: November 2, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.