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Protein

NAD kinase

Gene

nadK

Organism
Psychrobacter arcticus (strain DSM 17307 / 273-4)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei91Proton acceptorUniRule annotation1
Binding sitei96NADUniRule annotation1
Binding sitei176NADUniRule annotation1
Binding sitei193NADUniRule annotation1
Binding sitei195NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi91 – 92NADUniRule annotation2
Nucleotide bindingi165 – 166NADUniRule annotation2
Nucleotide bindingi206 – 211NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Psyc_1465
OrganismiPsychrobacter arcticus (strain DSM 17307 / 273-4)
Taxonomic identifieri259536 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter
Proteomesi
  • UP000000546 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002296821 – 325NAD kinaseAdd BLAST325

Interactioni

Protein-protein interaction databases

STRINGi259536.Psyc_1465.

Structurei

3D structure databases

ProteinModelPortaliQ4FRP5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91. Bacteria.
COG0061. LUCA.
HOGENOMiHOG000227221.
KOiK00858.
OMAiKLHWHEY.
OrthoDBiPOG091H02D1.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase. 1 hit.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4FRP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPHLHESELF HAIKNPAFRR IGLMGRARTR SVTQSIGQIA QIINDMNLTL
60 70 80 90 100
IMDVQTANLP TLNLTEIERV KIVKRSLIGE ICDLVIVVGG DGSILHAAEA
110 120 130 140 150
LARYRVPVLG VNRGRLGFLA DVKPDEAAFK LRQVLMGNYQ LDHRFLLTME
160 170 180 190 200
IREGRKIIHE DMALNDVVLH AGKSVHMIDF QMKIDGHDVY RQHSDGLIVA
210 220 230 240 250
TPTGSTAYAL SGGGPIIHPS MDAICLVPMH PHTLSSRPIV VSGTSEICIR
260 270 280 290 300
IHEDNRTQPM VSADGKPSTP LDQEQRLYIR KHPDKLTLLH PPGFDFYEAC
310 320
RTKLHWNVHA EEFSLDVDDD IMDDE
Length:325
Mass (Da):36,371
Last modified:April 4, 2006 - v2
Checksum:i5D97E5AFD5312FB5
GO

Sequence cautioni

The sequence AAZ19313 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000082 Genomic DNA. Translation: AAZ19313.1. Different initiation.

Genome annotation databases

EnsemblBacteriaiAAZ19313; AAZ19313; Psyc_1465.
KEGGipar:Psyc_1465.
PATRICi23057619. VBIPsyArc98534_1723.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000082 Genomic DNA. Translation: AAZ19313.1. Different initiation.

3D structure databases

ProteinModelPortaliQ4FRP5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi259536.Psyc_1465.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAZ19313; AAZ19313; Psyc_1465.
KEGGipar:Psyc_1465.
PATRICi23057619. VBIPsyArc98534_1723.

Phylogenomic databases

eggNOGiENOG4105F91. Bacteria.
COG0061. LUCA.
HOGENOMiHOG000227221.
KOiK00858.
OMAiKLHWHEY.
OrthoDBiPOG091H02D1.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase. 1 hit.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNADK_PSYA2
AccessioniPrimary (citable) accession number: Q4FRP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: November 2, 2016
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.