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Q4FR05 (UPPP_PSYA2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA
Ordered Locus Names:Psyc_1705
OrganismPsychrobacter arcticus (strain DSM 17307 / 273-4) [Complete proteome] [HAMAP]
Taxonomic identifier259536 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter

Protein attributes

Sequence length280 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 280280Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000227634

Regions

Transmembrane3 – 2321Helical; Potential
Transmembrane45 – 6521Helical; Potential
Transmembrane88 – 10821Helical; Potential
Transmembrane115 – 13521Helical; Potential
Transmembrane150 – 17021Helical; Potential
Transmembrane191 – 21121Helical; Potential
Transmembrane225 – 24521Helical; Potential
Transmembrane255 – 27521Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q4FR05 [UniParc].

Last modified August 30, 2005. Version 1.
Checksum: BC5EB1D22540D59E

FASTA28030,541
        10         20         30         40         50         60 
MDIILLIQAV IMGIVEGITE FLPISSTGYL ILSADLMGFW TKEKVDLFVV VVQFGAILAV 

        70         80         90        100        110        120 
IYDYWDRLWQ ALMGLLTGKA EGMSNPRQLG LSLIVATIPV MIVGFTFADE IKAYLFDPIV 

       130        140        150        160        170        180 
VAIMLIIGGL LIFYVENRPK PIIAQEAEDV GLKTALMIGL FQCLALIPGT SRSGATIVGA 

       190        200        210        220        230        240 
LWLGVSRKAS AEFSFFLGIP VIVGAALLDL LKHKDVLTSS EDWLVLGIGT VVSFIVALLC 

       250        260        270        280 
IRLLVAWVSR RDFKIFAWLR IITGVLVLIA AWGFGYQMAG 

« Hide

References

[1]"The genome sequence of Psychrobacter arcticus 273-4, a psychroactive Siberian permafrost bacterium, reveals mechanisms for adaptation to low-temperature growth."
Ayala-del-Rio H.L., Chain P.S., Grzymski J.J., Ponder M.A., Ivanova N., Bergholz P.W., Di Bartolo G., Hauser L., Land M., Bakermans C., Rodrigues D., Klappenbach J., Zarka D., Larimer F., Richardson P., Murray A., Thomashow M., Tiedje J.M.
Appl. Environ. Microbiol. 76:2304-2312(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 17307 / 273-4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000082 Genomic DNA. Translation: AAZ19553.1.
RefSeqYP_264987.1. NC_007204.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING259536.Psyc_1705.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAZ19553; AAZ19553; Psyc_1705.
GeneID3515673.
KEGGpar:Psyc_1705.
PATRIC23058209. VBIPsyArc98534_2011.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAYRIFIGA.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycPARC259536:GI3A-1748-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_PSYA2
AccessionPrimary (citable) accession number: Q4FR05
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: August 30, 2005
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families