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Q4FQF8

- HISX_PSYA2

UniProt

Q4FQF8 - HISX_PSYA2

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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Psychrobacter arcticus (strain DSM 17307 / 273-4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei130 – 1301NADUniRule annotation
Binding sitei191 – 1911NADUniRule annotation
Binding sitei214 – 2141NADUniRule annotation
Binding sitei237 – 2371SubstrateUniRule annotation
Metal bindingi261 – 2611ZincUniRule annotation
Binding sitei261 – 2611SubstrateUniRule annotation
Metal bindingi264 – 2641ZincUniRule annotation
Binding sitei264 – 2641SubstrateUniRule annotation
Active sitei329 – 3291Proton acceptorUniRule annotation
Active sitei330 – 3301Proton acceptorUniRule annotation
Binding sitei330 – 3301SubstrateUniRule annotation
Metal bindingi363 – 3631ZincUniRule annotation
Binding sitei363 – 3631SubstrateUniRule annotation
Binding sitei417 – 4171SubstrateUniRule annotation
Metal bindingi422 – 4221ZincUniRule annotation
Binding sitei422 – 4221SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciPARC259536:GI3A-1947-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:Psyc_1902
OrganismiPsychrobacter arcticus (strain DSM 17307 / 273-4)
Taxonomic identifieri259536 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter
ProteomesiUP000000546: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 431431Histidinol dehydrogenasePRO_0000135825Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi259536.Psyc_1902.

Structurei

3D structure databases

ProteinModelPortaliQ4FQF8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4FQF8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRQLSTQDAD FDSQLTELLA FETVNDATLL TTVDDIIARV RHGGDSVVLE
60 70 80 90 100
LTQQFDQHPA TTTQALELSK EALAEAFANL DDVVKSALIT AATRVKTFHE
110 120 130 140 150
RQVQETWQYE DELGNRLGQK VTALDRVGIY VPGGLASYPS SVLMNAIPAK
160 170 180 190 200
VAGVKEVIMV VPAPKGVLNP LVLAAAHLAK VDRVFTIGGA QAVAALAYGT
210 220 230 240 250
ETIPAVDKIT GPGNKYVAAA KRAVFGQVGI DMIAGPSEVL VYAEGEAQDR
260 270 280 290 300
ADWLAMDLLS QAEHDRIAQA IFVTTSAQQL KEVAIEIEKA LAELPKADIA
310 320 330 340 350
RDSLKNRGVL ILVRDREEGM AVINRVAPEH LELSVDHPDA LLNSIRHAGA
360 370 380 390 400
IFMGRHTPEA IGDYCAGPNH VLPTSGTARF SSPLGVYDFQ KKSSIIYCSE
410 420 430
SGSKPLAQTA DILAQHEDLE AHARSARYRY Q
Length:431
Mass (Da):46,506
Last modified:August 30, 2005 - v1
Checksum:i0F4BC4043056A41D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000082 Genomic DNA. Translation: AAZ19750.1.
RefSeqiYP_265184.1. NC_007204.1.

Genome annotation databases

EnsemblBacteriaiAAZ19750; AAZ19750; Psyc_1902.
GeneIDi3515872.
KEGGipar:Psyc_1902.
PATRICi23058695. VBIPsyArc98534_2252.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000082 Genomic DNA. Translation: AAZ19750.1 .
RefSeqi YP_265184.1. NC_007204.1.

3D structure databases

ProteinModelPortali Q4FQF8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 259536.Psyc_1902.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ19750 ; AAZ19750 ; Psyc_1902 .
GeneIDi 3515872.
KEGGi par:Psyc_1902.
PATRICi 23058695. VBIPsyArc98534_2252.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci PARC259536:GI3A-1947-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Psychrobacter arcticus 273-4, a psychroactive Siberian permafrost bacterium, reveals mechanisms for adaptation to low-temperature growth."
    Ayala-del-Rio H.L., Chain P.S., Grzymski J.J., Ponder M.A., Ivanova N., Bergholz P.W., Di Bartolo G., Hauser L., Land M., Bakermans C., Rodrigues D., Klappenbach J., Zarka D., Larimer F., Richardson P., Murray A., Thomashow M., Tiedje J.M.
    Appl. Environ. Microbiol. 76:2304-2312(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17307 / 273-4.

Entry informationi

Entry nameiHISX_PSYA2
AccessioniPrimary (citable) accession number: Q4FQF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: August 30, 2005
Last modified: October 1, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3