Skip Header

Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q4FQC7 (FADA_PSYA2)

Last modified February 9, 2010. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    3-ketoacyl-CoA thiolase
    EC=2.3.1.16
Alternative name(s):
    Fatty acid oxidation complex subunit beta
    Beta-ketothiolase
    Acetyl-CoA acyltransferase
Gene names
Name: fadA
Ordered Locus Names: Psyc_1933
OrganismPsychrobacter arcticus (strain DSM 17307 / 273-4) [Complete proteome] [HAMAP]
Taxonomic identifier259536 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter

Protein attributes

Sequence length390 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed By similarity. HAMAP MF_01620

Catalytic activity

Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. HAMAP MF_01620

Pathway

Lipid metabolism; fatty acid beta-oxidation. HAMAP MF_01620

Subunit structure

Heterotetramer of two alpha chains (fadB) and two beta chains (fadA) By similarity. HAMAP MF_01620

Subcellular location

Cytoplasm By similarity HAMAP MF_01620.

Sequence similarities

Belongs to the thiolase family.

Ontologies

Keywords
   Biological processFatty acid metabolism
Lipid degradation
Lipid metabolism
   Cellular componentCytoplasm
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processfatty acid metabolic process

Inferred from electronic annotation. Source: HAMAP

lipid catabolic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionacetyl-CoA C-acyltransferase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3903903-ketoacyl-CoA thiolase HAMAP MF_01620
PRO_0000206387

Sites

Active site951Acyl-thioester intermediate By similarity
Active site3461Proton acceptor By similarity
Active site3761Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4FQC7-1 [UniParc].

Last modified August 30, 2005. Version 1.
Checksum: 90911DC161B5FCA0

FASTA39041,395
        10         20         30         40         50         60 
MTILSPKDVV IVDGVRSAMG KTKNGMFRHV RADSMSAELV RALVERNDFD PRDVEDIIWG 

        70         80         90        100        110        120 
CVNQTLEQGL NIGRNIGLLA GIPKTAGGQT VNRLCGSSMQ ALHTAAAQIM TGQGDVFIIG 

       130        140        150        160        170        180 
GVEHMGHVGM MHGIDLNPEA SKHYAKASNM MGLTAEMLGR MNNITREEQD AFGLESHRRA 

       190        200        210        220        230        240 
WAATTEGRFD NEIIGIEGHD AAGRLQLCTV DEVIRPDATM EQMQKLRPAF DPVSGTVTAA 

       250        260        270        280        290        300 
TSSALSDGAS AMLIMSAQKA KELGLKPRAR IRSMAVAGCD AAIMGYGPVP ATQKALKRAG 

       310        320        330        340        350        360 
MSIEDMQTIE LNEAFAAQGL SVLKALNLTD KQDIVNINGG AIALGHPLGC SGARITVTLL 

       370        380        390 
NAMEQSDTEI GLATMCIGLG QGISTIIERV 

« Hide

References

[1]"Complete sequence of Psychrobacter arcticum 273-4."
NASA Astrobiology Institute
Ayala-del-Rio H.L., Chain P., Ponder M.A., Di Bartolo G., Ivanova N., Bergholz P.W., Hauser L., Land M., Bakermans C., Rodrigues D., Klappenbach J.A., Zarka D., Larimer F., Richardson P., Thomashow M.F., Tiedje J.M.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000082 Genomic DNA. Translation: AAZ19781.1.
RefSeqYP_265215.1.

3D structure databases

SMRQ4FQC7. Positions 4-390.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ4FQC7.

Genome annotation databases

GeneID3515903.
GenomeReviewsGene locus Psyc_1933 in contig CP000082_GR.
KEGGpar:Psyc_1933.
NMPDRfig|259536.4.peg.1753.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0183.
HOGENOMHBG370930.
OMAQDIVNIN.
PhylomeDBQ4FQC7.

Enzyme and pathway databases

BioCycPARC259536:PSYC_1933-MONOMER.

Family and domain databases

HAMAPMF_01620. FadA.
[Tree]
InterProIPR012805. FadA.
IPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020610. Thiolase_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 1 hit.
PANTHERPTHR18919. Thiolase. 1 hit.
PfamPF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
[Graphical view]
PIRSFPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
TIGRFAMsTIGR01930. AcCoA-C-Actrans. 1 hit.
TIGR02445. fadA. 1 hit.
PROSITEPS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
PS00099. THIOLASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFADA_PSYA2
AccessionPrimary (citable) accession number: Q4FQC7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: August 30, 2005
Last modified: February 9, 2010
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents