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Q4FQB9

- CLPP_PSYA2

UniProt

Q4FQB9 - CLPP_PSYA2

Protein

ATP-dependent Clp protease proteolytic subunit

Gene

clpP

Organism
Psychrobacter arcticus (strain DSM 17307 / 273-4)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (30 Aug 2005)
      Previous versions | rss
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    Functioni

    Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.UniRule annotation

    Catalytic activityi

    Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei126 – 1261NucleophileUniRule annotation
    Active sitei151 – 1511UniRule annotation

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Enzyme and pathway databases

    BioCyciPARC259536:GI3A-1986-MONOMER.

    Protein family/group databases

    MEROPSiS14.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-dependent Clp protease proteolytic subunitUniRule annotation (EC:3.4.21.92UniRule annotation)
    Alternative name(s):
    Endopeptidase ClpUniRule annotation
    Gene namesi
    Name:clpPUniRule annotation
    Ordered Locus Names:Psyc_1941
    OrganismiPsychrobacter arcticus (strain DSM 17307 / 273-4)
    Taxonomic identifieri259536 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter
    ProteomesiUP000000546: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 225225ATP-dependent Clp protease proteolytic subunitPRO_0000226463Add
    BLAST

    Interactioni

    Subunit structurei

    Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.UniRule annotation

    Protein-protein interaction databases

    STRINGi259536.Psyc_1941.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4FQB9.
    SMRiQ4FQB9. Positions 30-221.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S14 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0740.
    HOGENOMiHOG000285833.
    KOiK01358.
    OMAiKGERSFD.
    OrthoDBiEOG6Z3KQ0.

    Family and domain databases

    Gene3Di3.90.226.10. 1 hit.
    HAMAPiMF_00444. ClpP.
    InterProiIPR001907. ClpP.
    IPR029045. ClpP/crotonase-like_dom.
    IPR023562. ClpP/TepA.
    IPR018215. ClpP_AS.
    [Graphical view]
    PANTHERiPTHR10381. PTHR10381. 1 hit.
    PfamiPF00574. CLP_protease. 1 hit.
    [Graphical view]
    PRINTSiPR00127. CLPPROTEASEP.
    SUPFAMiSSF52096. SSF52096. 1 hit.
    TIGRFAMsiTIGR00493. clpP. 1 hit.
    PROSITEiPS00382. CLP_PROTEASE_HIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4FQB9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDYDRITAN PHFDMLMSAH NHVQSTTQSA LVPMVVEQSA RGERSFDIFS    50
    RLLRERVIFL TGQVEDHMAN LIVAQLLFLE AENPDKDIHL YINSPGGSVS 100
    AGLAIFDTMN FIKPEVSTIC MGGAYSMGSF LLAAGQKGKR YALANARVMI 150
    HQPSGGAQGQ ATDIEINARE ILKTRARLNE ILAERTGQSV EKIEKDVERD 200
    YWLDAKEAKE YGLIDEVLER RPASL 225
    Length:225
    Mass (Da):25,056
    Last modified:August 30, 2005 - v1
    Checksum:iEFB0E14A3617304C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000082 Genomic DNA. Translation: AAZ19789.1.
    RefSeqiYP_265223.1. NC_007204.1.

    Genome annotation databases

    EnsemblBacteriaiAAZ19789; AAZ19789; Psyc_1941.
    GeneIDi3515911.
    KEGGipar:Psyc_1941.
    PATRICi23058779. VBIPsyArc98534_2294.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000082 Genomic DNA. Translation: AAZ19789.1 .
    RefSeqi YP_265223.1. NC_007204.1.

    3D structure databases

    ProteinModelPortali Q4FQB9.
    SMRi Q4FQB9. Positions 30-221.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 259536.Psyc_1941.

    Protein family/group databases

    MEROPSi S14.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ19789 ; AAZ19789 ; Psyc_1941 .
    GeneIDi 3515911.
    KEGGi par:Psyc_1941.
    PATRICi 23058779. VBIPsyArc98534_2294.

    Phylogenomic databases

    eggNOGi COG0740.
    HOGENOMi HOG000285833.
    KOi K01358.
    OMAi KGERSFD.
    OrthoDBi EOG6Z3KQ0.

    Enzyme and pathway databases

    BioCyci PARC259536:GI3A-1986-MONOMER.

    Family and domain databases

    Gene3Di 3.90.226.10. 1 hit.
    HAMAPi MF_00444. ClpP.
    InterProi IPR001907. ClpP.
    IPR029045. ClpP/crotonase-like_dom.
    IPR023562. ClpP/TepA.
    IPR018215. ClpP_AS.
    [Graphical view ]
    PANTHERi PTHR10381. PTHR10381. 1 hit.
    Pfami PF00574. CLP_protease. 1 hit.
    [Graphical view ]
    PRINTSi PR00127. CLPPROTEASEP.
    SUPFAMi SSF52096. SSF52096. 1 hit.
    TIGRFAMsi TIGR00493. clpP. 1 hit.
    PROSITEi PS00382. CLP_PROTEASE_HIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Psychrobacter arcticus 273-4, a psychroactive Siberian permafrost bacterium, reveals mechanisms for adaptation to low-temperature growth."
      Ayala-del-Rio H.L., Chain P.S., Grzymski J.J., Ponder M.A., Ivanova N., Bergholz P.W., Di Bartolo G., Hauser L., Land M., Bakermans C., Rodrigues D., Klappenbach J., Zarka D., Larimer F., Richardson P., Murray A., Thomashow M., Tiedje J.M.
      Appl. Environ. Microbiol. 76:2304-2312(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 17307 / 273-4.

    Entry informationi

    Entry nameiCLPP_PSYA2
    AccessioniPrimary (citable) accession number: Q4FQB9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: August 30, 2005
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3