Reviewed, UniProtKB/Swiss-Prot Q4FQB8 (CLPX_PSYA2)

Names and origin

Protein names

Recommended name:
ATP-dependent Clp protease ATP-binding subunit clpX

Gene names

Name:	clpX
Ordered Locus Names:	Psyc_1942

Organism

Psychrobacter arcticus (strain DSM 17307 / 273-4) [Complete proteome] [HAMAP]

Taxonomic identifier

259536 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Psychrobacter

Protein attributes

Sequence length	424 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of clpP By similarity. HAMAP MF_00175
Subunit structure	Heterodimer of clpP and clpX By similarity. HAMAP MF_00175
Sequence similarities	Belongs to the clpX chaperone family.

Ontologies

Keywords
Domain	Zinc-finger
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Chaperone
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP ATPase activity Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro unfolded protein binding Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 424	424	ATP-dependent Clp protease ATP-binding subunit clpX HAMAP MF_00175		PRO_1000071625
Regions
	Zinc finger	9 – 34	26	C4-type HAMAP MF_00175
	Nucleotide binding	132 – 139	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q4FQB8-1 [UniParc]. Last modified August 30, 2005. Version 1. Checksum: 042880532C3EB7F6	FASTA	424	46,028
	10 20 30 40 50 60 MAEDNTPLCS FCGKEKSEVK QLIAADDANI CNECIELCTD LIADSDENTD DDSDIDTSWV 70 80 90 100 110 120 NKKLPTPKEL RAKLDEYVIG QDAAKKALAV AVYNHYKRLK VSQTLANDSK KAKIGAADAM 130 140 150 160 170 180 VELAKSNILL IGPTGSGKTL LAQTLARLLD VPFAMADATT LTEAGYVGED VENIVQKLLQ 190 200 210 220 230 240 ASDYDVSKAE QGIIYIDEID KISKKGDNPS ITRDVSGEGV QQALLKLIEG TVAAIPPHGG 250 260 270 280 290 300 RKHPQQELIQ VDTSNILIIV GGAFAGLDKV IQQRTEKTGI GFNADVSSKD DSRRSSELLQ 310 320 330 340 350 360 QVEPEDLIKF GLIPELIGRL PVLAALTELD EDALVQILTE PKNALVKQYK YLFDMEGADI 370 380 390 400 410 420 TFTKEALDAI AKKAMARKTG ARGLRSIVEN ALLETMYELP SMKNAKTVLV DEQVINEGKT PEIA

References

[1]

"Complete sequence of Psychrobacter arcticum 273-4." NASA Astrobiology Institute Ayala-del-Rio H.L., Chain P., Ponder M.A., Di Bartolo G., Ivanova N., Bergholz P.W., Hauser L., Land M., Bakermans C., Rodrigues D., Klappenbach J.A., Zarka D., Larimer F., Richardson P., Thomashow M.F., Tiedje J.M. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000082 Genomic DNA. Translation: AAZ19790.1.
RefSeq	YP_265224.1.
3D structure databases
HSSP	HSSP built from PDB template 1YYF based on UniProtKB P0A6H5.
SMR	Q4FQB8. Positions 8-42, 62-422.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4FQB8.
Genome annotation databases
GeneID	3515912.
GenomeReviews	Gene locus Psyc_1942 in contig CP000082_GR.
KEGG	par:Psyc_1942.
NMPDR	fig|259536.4.peg.1761.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1219.
HOGENOM	HBG745965.
OMA	FCGKSQE.
PhylomeDB	Q4FQB8.
ProtClustDB	PRK05342.
Enzyme and pathway databases
BioCyc	PARC259536:PSYC_1942-MONOMER.
Family and domain databases
HAMAP	MF_00175. ClpX. [Tree]
InterPro	IPR003593. ATPase_AAA+_core. IPR013093. ATPase_AAA-2. IPR019489. Clp_ATPase_C. IPR004487. Clp_protease_ATP-bd_su_ClpX. IPR010603. Znf_C4. [Graphical view]
PANTHER	PTHR11262:SF4. ClpX. 1 hit.
Pfam	PF07724. AAA_2. 1 hit. PF10431. ClpB_D2-small. 1 hit. PF06689. zf-C4_ClpX. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00382. clpX. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CLPX_PSYA2

Accession

Primary (citable) accession number: Q4FQB8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	August 30, 2005
Last modified:	March 2, 2010
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)