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Q4FQ25

- CPDA_PSYA2

UniProt

Q4FQ25 - CPDA_PSYA2

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Protein
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA
Gene
cpdA, Psyc_2036
Organism
Psychrobacter arcticus (strain DSM 17307 / 273-4)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes By similarity.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

Binds 2 metal cations per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi23 – 231Metal cation 1 By similarity
Metal bindingi25 – 251Metal cation 1 By similarity
Binding sitei25 – 251cAMP By similarity
Metal bindingi70 – 701Metal cation 1 By similarity
Metal bindingi70 – 701Metal cation 2 By similarity
Binding sitei70 – 701cAMP By similarity
Metal bindingi100 – 1001Metal cation 2 By similarity
Metal bindingi179 – 1791Metal cation 2 By similarity
Metal bindingi218 – 2181Metal cation 2 By similarity
Metal bindingi220 – 2201Metal cation 1 By similarity
Binding sitei220 – 2201cAMP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi100 – 1012cAMP By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-HAMAP
  3. nucleotide binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPARC259536:GI3A-2086-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA (EC:3.1.4.17)
Short name:
3',5'-cyclic AMP phosphodiesterase
Short name:
cAMP phosphodiesterase
Gene namesi
Name:cpdA
Ordered Locus Names:Psyc_2036
OrganismiPsychrobacter arcticus (strain DSM 17307 / 273-4)
Taxonomic identifieri259536 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter
ProteomesiUP000000546: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2792793',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation
PRO_0000413374Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi259536.Psyc_2036.

Structurei

3D structure databases

ProteinModelPortaliQ4FQ25.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1409.
HOGENOMiHOG000289889.
KOiK03651.
OMAiWREIELH.
OrthoDBiEOG6QG8GQ.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA.
InterProiIPR013622. Calcineurin-like_phos_C.
IPR024654. Calcineurin-like_PHP_lpxH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF12850. Metallophos_2. 1 hit.
[Graphical view]
ProDomiPD587589. Calcineurin-like_phos_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4FQ25-1 [UniParc]FASTAAdd to Basket

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MPSYPVSTVN TPDGQVNVLQ ITDLHLSSHV PASDDETSSE VAVCQYSFEA    50
IIKQALSKEI RCDLIVVTGD LVNKVEPAIY DHIFTVLQDT GIPFACIAGN 100
HDVTDETGED LPFYQRTLIT RAADPRLLSR HLIESEHWQL LLLDSSITGK 150
VEGEITATDI DWVREQLASC TKPALIALHH HVLPVDSEWI DSHMAKNAEE 200
FWQHILPFEN LRVIINGHTH QEQTRHHQGV TVYSTPSTCY QFKPFEDNFA 250
YDKKVRPGYR WLQLANNGKV ASWVERLDT 279
Length:279
Mass (Da):31,594
Last modified:August 30, 2005 - v1
Checksum:iCC5681C715B10231
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000082 Genomic DNA. Translation: AAZ19883.1.
RefSeqiYP_265317.1. NC_007204.1.

Genome annotation databases

EnsemblBacteriaiAAZ19883; AAZ19883; Psyc_2036.
GeneIDi3516010.
KEGGipar:Psyc_2036.
PATRICi23059005. VBIPsyArc98534_2402.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000082 Genomic DNA. Translation: AAZ19883.1 .
RefSeqi YP_265317.1. NC_007204.1.

3D structure databases

ProteinModelPortali Q4FQ25.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 259536.Psyc_2036.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ19883 ; AAZ19883 ; Psyc_2036 .
GeneIDi 3516010.
KEGGi par:Psyc_2036.
PATRICi 23059005. VBIPsyArc98534_2402.

Phylogenomic databases

eggNOGi COG1409.
HOGENOMi HOG000289889.
KOi K03651.
OMAi WREIELH.
OrthoDBi EOG6QG8GQ.

Enzyme and pathway databases

BioCyci PARC259536:GI3A-2086-MONOMER.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
HAMAPi MF_00905. cAMP_phophodiest_CpdA.
InterProi IPR013622. Calcineurin-like_phos_C.
IPR024654. Calcineurin-like_PHP_lpxH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
Pfami PF12850. Metallophos_2. 1 hit.
[Graphical view ]
ProDomi PD587589. Calcineurin-like_phos_C. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF56300. SSF56300. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Psychrobacter arcticus 273-4, a psychroactive Siberian permafrost bacterium, reveals mechanisms for adaptation to low-temperature growth."
    Ayala-del-Rio H.L., Chain P.S., Grzymski J.J., Ponder M.A., Ivanova N., Bergholz P.W., Di Bartolo G., Hauser L., Land M., Bakermans C., Rodrigues D., Klappenbach J., Zarka D., Larimer F., Richardson P., Murray A., Thomashow M., Tiedje J.M.
    Appl. Environ. Microbiol. 76:2304-2312(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17307 / 273-4.

Entry informationi

Entry nameiCPDA_PSYA2
AccessioniPrimary (citable) accession number: Q4FQ25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: August 30, 2005
Last modified: June 11, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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