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Q4FQ25

- CPDA_PSYA2

UniProt

Q4FQ25 - CPDA_PSYA2

Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Psychrobacter arcticus (strain DSM 17307 / 273-4)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (30 Aug 2005)
      Previous versions | rss
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    Functioni

    Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

    Catalytic activityi

    Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

    Cofactori

    Binds 2 metal cations per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi23 – 231Metal cation 1UniRule annotation
    Metal bindingi25 – 251Metal cation 1UniRule annotation
    Binding sitei25 – 251cAMPUniRule annotation
    Metal bindingi70 – 701Metal cation 1UniRule annotation
    Metal bindingi70 – 701Metal cation 2UniRule annotation
    Binding sitei70 – 701cAMPUniRule annotation
    Metal bindingi100 – 1001Metal cation 2UniRule annotation
    Metal bindingi179 – 1791Metal cation 2UniRule annotation
    Metal bindingi218 – 2181Metal cation 2UniRule annotation
    Metal bindingi220 – 2201Metal cation 1UniRule annotation
    Binding sitei220 – 2201cAMPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi100 – 1012cAMPUniRule annotation

    GO - Molecular functioni

    1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-HAMAP
    3. nucleotide binding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cAMP, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPARC259536:GI3A-2086-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.17UniRule annotation)
    Short name:
    3',5'-cyclic AMP phosphodiesteraseUniRule annotation
    Short name:
    cAMP phosphodiesteraseUniRule annotation
    Gene namesi
    Name:cpdAUniRule annotation
    Ordered Locus Names:Psyc_2036
    OrganismiPsychrobacter arcticus (strain DSM 17307 / 273-4)
    Taxonomic identifieri259536 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter
    ProteomesiUP000000546: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2792793',5'-cyclic adenosine monophosphate phosphodiesterase CpdAPRO_0000413374Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi259536.Psyc_2036.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4FQ25.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1409.
    HOGENOMiHOG000289889.
    KOiK03651.
    OMAiWREIELH.
    OrthoDBiEOG6QG8GQ.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    HAMAPiMF_00905. cAMP_phophodiest_CpdA.
    InterProiIPR013622. Calcineurin-like_phos_C.
    IPR024654. Calcineurin-like_PHP_lpxH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view]
    PfamiPF12850. Metallophos_2. 1 hit.
    [Graphical view]
    ProDomiPD587589. Calcineurin-like_phos_C. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF56300. SSF56300. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q4FQ25-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSYPVSTVN TPDGQVNVLQ ITDLHLSSHV PASDDETSSE VAVCQYSFEA    50
    IIKQALSKEI RCDLIVVTGD LVNKVEPAIY DHIFTVLQDT GIPFACIAGN 100
    HDVTDETGED LPFYQRTLIT RAADPRLLSR HLIESEHWQL LLLDSSITGK 150
    VEGEITATDI DWVREQLASC TKPALIALHH HVLPVDSEWI DSHMAKNAEE 200
    FWQHILPFEN LRVIINGHTH QEQTRHHQGV TVYSTPSTCY QFKPFEDNFA 250
    YDKKVRPGYR WLQLANNGKV ASWVERLDT 279
    Length:279
    Mass (Da):31,594
    Last modified:August 30, 2005 - v1
    Checksum:iCC5681C715B10231
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000082 Genomic DNA. Translation: AAZ19883.1.
    RefSeqiYP_265317.1. NC_007204.1.

    Genome annotation databases

    EnsemblBacteriaiAAZ19883; AAZ19883; Psyc_2036.
    GeneIDi3516010.
    KEGGipar:Psyc_2036.
    PATRICi23059005. VBIPsyArc98534_2402.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000082 Genomic DNA. Translation: AAZ19883.1 .
    RefSeqi YP_265317.1. NC_007204.1.

    3D structure databases

    ProteinModelPortali Q4FQ25.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 259536.Psyc_2036.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ19883 ; AAZ19883 ; Psyc_2036 .
    GeneIDi 3516010.
    KEGGi par:Psyc_2036.
    PATRICi 23059005. VBIPsyArc98534_2402.

    Phylogenomic databases

    eggNOGi COG1409.
    HOGENOMi HOG000289889.
    KOi K03651.
    OMAi WREIELH.
    OrthoDBi EOG6QG8GQ.

    Enzyme and pathway databases

    BioCyci PARC259536:GI3A-2086-MONOMER.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    HAMAPi MF_00905. cAMP_phophodiest_CpdA.
    InterProi IPR013622. Calcineurin-like_phos_C.
    IPR024654. Calcineurin-like_PHP_lpxH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view ]
    Pfami PF12850. Metallophos_2. 1 hit.
    [Graphical view ]
    ProDomi PD587589. Calcineurin-like_phos_C. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Psychrobacter arcticus 273-4, a psychroactive Siberian permafrost bacterium, reveals mechanisms for adaptation to low-temperature growth."
      Ayala-del-Rio H.L., Chain P.S., Grzymski J.J., Ponder M.A., Ivanova N., Bergholz P.W., Di Bartolo G., Hauser L., Land M., Bakermans C., Rodrigues D., Klappenbach J., Zarka D., Larimer F., Richardson P., Murray A., Thomashow M., Tiedje J.M.
      Appl. Environ. Microbiol. 76:2304-2312(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 17307 / 273-4.

    Entry informationi

    Entry nameiCPDA_PSYA2
    AccessioniPrimary (citable) accession number: Q4FQ25
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2011
    Last sequence update: August 30, 2005
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3