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Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Psychrobacter arcticus (strain DSM 17307 / 273-4)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

a metal cationUniRule annotationNote: Binds 2 metal cations per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi23Metal cation 1UniRule annotation1
Metal bindingi25Metal cation 1UniRule annotation1
Binding sitei25cAMPUniRule annotation1
Metal bindingi70Metal cation 1UniRule annotation1
Metal bindingi70Metal cation 2UniRule annotation1
Binding sitei70cAMPUniRule annotation1
Metal bindingi100Metal cation 2UniRule annotation1
Metal bindingi179Metal cation 2UniRule annotation1
Metal bindingi218Metal cation 2UniRule annotation1
Metal bindingi220Metal cation 1UniRule annotation1
Binding sitei220cAMPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi100 – 101cAMPUniRule annotation2

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandcAMP, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPARC259536:G1G4M-2123-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.53UniRule annotation)
Short name:
3',5'-cyclic AMP phosphodiesteraseUniRule annotation
Short name:
cAMP phosphodiesteraseUniRule annotation
Gene namesi
Name:cpdAUniRule annotation
Ordered Locus Names:Psyc_2036
OrganismiPsychrobacter arcticus (strain DSM 17307 / 273-4)
Taxonomic identifieri259536 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter
Proteomesi
  • UP000000546 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004133741 – 2793',5'-cyclic adenosine monophosphate phosphodiesterase CpdAAdd BLAST279

Interactioni

Protein-protein interaction databases

STRINGi259536.Psyc_2036

Structurei

3D structure databases

ProteinModelPortaliQ4FQ25
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1409 LUCA
HOGENOMiHOG000289889
KOiK03651
OMAiCAWLDQH
OrthoDBiPOG091H05L5

Family and domain databases

Gene3Di3.60.21.10, 1 hit
HAMAPiMF_00905 cAMP_phophodiest_CpdA, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR026575 cAMP_Pdiest_CpdA
IPR013622 CpdA_C
IPR029052 Metallo-depent_PP-like
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD587589 Calcineurin-like_phos_C, 1 hit

Sequencei

Sequence statusi: Complete.

Q4FQ25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSYPVSTVN TPDGQVNVLQ ITDLHLSSHV PASDDETSSE VAVCQYSFEA
60 70 80 90 100
IIKQALSKEI RCDLIVVTGD LVNKVEPAIY DHIFTVLQDT GIPFACIAGN
110 120 130 140 150
HDVTDETGED LPFYQRTLIT RAADPRLLSR HLIESEHWQL LLLDSSITGK
160 170 180 190 200
VEGEITATDI DWVREQLASC TKPALIALHH HVLPVDSEWI DSHMAKNAEE
210 220 230 240 250
FWQHILPFEN LRVIINGHTH QEQTRHHQGV TVYSTPSTCY QFKPFEDNFA
260 270
YDKKVRPGYR WLQLANNGKV ASWVERLDT
Length:279
Mass (Da):31,594
Last modified:August 30, 2005 - v1
Checksum:iCC5681C715B10231
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000082 Genomic DNA Translation: AAZ19883.1
RefSeqiWP_011281290.1, NC_007204.1

Genome annotation databases

EnsemblBacteriaiAAZ19883; AAZ19883; Psyc_2036
KEGGipar:Psyc_2036

Similar proteinsi

Entry informationi

Entry nameiCPDA_PSYA2
AccessioniPrimary (citable) accession number: Q4FQ25
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: August 30, 2005
Last modified: April 25, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health