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Q4FQ25

- CPDA_PSYA2

UniProt

Q4FQ25 - CPDA_PSYA2

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Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Psychrobacter arcticus (strain DSM 17307 / 273-4)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

a metal cationUniRule annotationNote: Binds 2 metal cations per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi23 – 231Metal cation 1UniRule annotation
Metal bindingi25 – 251Metal cation 1UniRule annotation
Binding sitei25 – 251cAMPUniRule annotation
Metal bindingi70 – 701Metal cation 1UniRule annotation
Metal bindingi70 – 701Metal cation 2UniRule annotation
Binding sitei70 – 701cAMPUniRule annotation
Metal bindingi100 – 1001Metal cation 2UniRule annotation
Metal bindingi179 – 1791Metal cation 2UniRule annotation
Metal bindingi218 – 2181Metal cation 2UniRule annotation
Metal bindingi220 – 2201Metal cation 1UniRule annotation
Binding sitei220 – 2201cAMPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi100 – 1012cAMPUniRule annotation

GO - Molecular functioni

  1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-HAMAP
  3. nucleotide binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPARC259536:GI3A-2086-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.17UniRule annotation)
Short name:
3',5'-cyclic AMP phosphodiesteraseUniRule annotation
Short name:
cAMP phosphodiesteraseUniRule annotation
Gene namesi
Name:cpdAUniRule annotation
Ordered Locus Names:Psyc_2036
OrganismiPsychrobacter arcticus (strain DSM 17307 / 273-4)
Taxonomic identifieri259536 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter
ProteomesiUP000000546: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2792793',5'-cyclic adenosine monophosphate phosphodiesterase CpdAPRO_0000413374Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi259536.Psyc_2036.

Structurei

3D structure databases

ProteinModelPortaliQ4FQ25.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1409.
HOGENOMiHOG000289889.
KOiK03651.
OMAiWREIELH.
OrthoDBiEOG6QG8GQ.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA.
InterProiIPR013622. Calcineurin-like_phos_C.
IPR024654. Calcineurin-like_PHP_lpxH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF12850. Metallophos_2. 1 hit.
[Graphical view]
ProDomiPD587589. Calcineurin-like_phos_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4FQ25-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPSYPVSTVN TPDGQVNVLQ ITDLHLSSHV PASDDETSSE VAVCQYSFEA
60 70 80 90 100
IIKQALSKEI RCDLIVVTGD LVNKVEPAIY DHIFTVLQDT GIPFACIAGN
110 120 130 140 150
HDVTDETGED LPFYQRTLIT RAADPRLLSR HLIESEHWQL LLLDSSITGK
160 170 180 190 200
VEGEITATDI DWVREQLASC TKPALIALHH HVLPVDSEWI DSHMAKNAEE
210 220 230 240 250
FWQHILPFEN LRVIINGHTH QEQTRHHQGV TVYSTPSTCY QFKPFEDNFA
260 270
YDKKVRPGYR WLQLANNGKV ASWVERLDT
Length:279
Mass (Da):31,594
Last modified:August 30, 2005 - v1
Checksum:iCC5681C715B10231
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000082 Genomic DNA. Translation: AAZ19883.1.
RefSeqiYP_265317.1. NC_007204.1.

Genome annotation databases

EnsemblBacteriaiAAZ19883; AAZ19883; Psyc_2036.
GeneIDi3516010.
KEGGipar:Psyc_2036.
PATRICi23059005. VBIPsyArc98534_2402.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000082 Genomic DNA. Translation: AAZ19883.1 .
RefSeqi YP_265317.1. NC_007204.1.

3D structure databases

ProteinModelPortali Q4FQ25.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 259536.Psyc_2036.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ19883 ; AAZ19883 ; Psyc_2036 .
GeneIDi 3516010.
KEGGi par:Psyc_2036.
PATRICi 23059005. VBIPsyArc98534_2402.

Phylogenomic databases

eggNOGi COG1409.
HOGENOMi HOG000289889.
KOi K03651.
OMAi WREIELH.
OrthoDBi EOG6QG8GQ.

Enzyme and pathway databases

BioCyci PARC259536:GI3A-2086-MONOMER.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
HAMAPi MF_00905. cAMP_phophodiest_CpdA.
InterProi IPR013622. Calcineurin-like_phos_C.
IPR024654. Calcineurin-like_PHP_lpxH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
Pfami PF12850. Metallophos_2. 1 hit.
[Graphical view ]
ProDomi PD587589. Calcineurin-like_phos_C. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF56300. SSF56300. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Psychrobacter arcticus 273-4, a psychroactive Siberian permafrost bacterium, reveals mechanisms for adaptation to low-temperature growth."
    Ayala-del-Rio H.L., Chain P.S., Grzymski J.J., Ponder M.A., Ivanova N., Bergholz P.W., Di Bartolo G., Hauser L., Land M., Bakermans C., Rodrigues D., Klappenbach J., Zarka D., Larimer F., Richardson P., Murray A., Thomashow M., Tiedje J.M.
    Appl. Environ. Microbiol. 76:2304-2312(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17307 / 273-4.

Entry informationi

Entry nameiCPDA_PSYA2
AccessioniPrimary (citable) accession number: Q4FQ25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: August 30, 2005
Last modified: November 26, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3