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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Psychrobacter arcticus (strain DSM 17307 / 273-4)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciPARC259536:G1G4M-2139-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:Psyc_2051
OrganismiPsychrobacter arcticus (strain DSM 17307 / 273-4)
Taxonomic identifieri259536 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter
Proteomesi
  • UP000000546 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 41HelicalUniRule annotationAdd BLAST21
Transmembranei71 – 91HelicalUniRule annotationAdd BLAST21
Transmembranei98 – 118HelicalUniRule annotationAdd BLAST21
Transmembranei134 – 154HelicalUniRule annotationAdd BLAST21
Transmembranei176 – 196HelicalUniRule annotationAdd BLAST21
Transmembranei211 – 231HelicalUniRule annotationAdd BLAST21
Transmembranei251 – 271HelicalUniRule annotationAdd BLAST21
Transmembranei275 – 295HelicalUniRule annotationAdd BLAST21
Transmembranei300 – 320HelicalUniRule annotationAdd BLAST21
Transmembranei349 – 369HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002354731 – 372Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST372

Interactioni

Protein-protein interaction databases

STRINGi259536.Psyc_2051

Structurei

3D structure databases

SMRiQ4FQ10
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY Bacteria
COG0472 LUCA
HOGENOMiHOG000275122
KOiK01000
OMAiLMSPLHH
OrthoDBiPOG091H00VH

Family and domain databases

CDDicd06852 GT_MraY, 1 hit
HAMAPiMF_00038 MraY, 1 hit
InterProiView protein in InterPro
IPR000715 Glycosyl_transferase_4
IPR003524 PNAcMuramoyl-5peptid_Trfase
IPR018480 PNAcMuramoyl-5peptid_Trfase_CS
PANTHERiPTHR22926 PTHR22926, 1 hit
PfamiView protein in Pfam
PF00953 Glycos_transf_4, 1 hit
PF10555 MraY_sig1, 1 hit
TIGRFAMsiTIGR00445 mraY, 1 hit
PROSITEiView protein in PROSITE
PS01347 MRAY_1, 1 hit
PS01348 MRAY_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q4FQ10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVWLFGWLG QYYAPFSAVS SLTLRALLAV ITALAFSMIF GSRVIRRLRA
60 70 80 90 100
LKYGQAIRND GPQSHLVKTG TPTMGGVLIL SAIGVSTLLW ARLNNPYVWI
110 120 130 140 150
LLIVMIIFGA VGWADDWLKI KYKNPKGLIA RKKYFWLSMG ALFVGISLYY
160 170 180 190 200
IATLQPNVVT TREMQDLLLP IFKDWMIPFS AVPFGIGFII FTYFVINGAS
210 220 230 240 250
NAVNLTDGLD GLAILPVVLV AAGLGAMAYV SGDVRFADYL HVPYIAYNSE
260 270 280 290 300
VIIVCGAMIG AGLGFLWFNA HPAQVFMGDV GALSLGAMLG TIAVMTRQEI
310 320 330 340 350
AFAIMGGLFV AEALSVMLQV GSYKLRKKRV FRMAPLHHHF EEIGWKETQV
360 370
VARFWIIAII LVILGLMTLK LR
Length:372
Mass (Da):41,047
Last modified:August 30, 2005 - v1
Checksum:iD12C035DBB7FA9D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000082 Genomic DNA Translation: AAZ19898.1
RefSeqiWP_011281305.1, NC_007204.1

Genome annotation databases

EnsemblBacteriaiAAZ19898; AAZ19898; Psyc_2051
KEGGipar:Psyc_2051

Similar proteinsi

Entry informationi

Entry nameiMRAY_PSYA2
AccessioniPrimary (citable) accession number: Q4FQ10
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: August 30, 2005
Last modified: February 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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