Reviewed, UniProtKB/Swiss-Prot Q4FPT7 (GPH_PSYA2)

Names and origin

Protein names

Recommended name:
    Phosphoglycolate phosphatase
      Short name=PGPase
      Short name=PGP
    EC=3.1.3.18

Gene names

Ordered Locus Names:

Psyc_2124

Organism

Psychrobacter arcticus (strain DSM 17307 / 273-4) [Complete proteome] [HAMAP]

Taxonomic identifier

259536 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Psychrobacter

Protein attributes

Sequence length	230 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress By similarity.
Catalytic activity	2-phosphoglycolate + H2O = glycolate + phosphate. HAMAP MF_00495
Pathway	Organic acid metabolism; glycolic acid biosynthesis; glycolic acid from 2-phosphoglycolic acid: step 1/1. HAMAP MF_00495
Sequence similarities	Belongs to the HAD-like hydrolase superfamily. CbbY/cbbZ/gph/yieH family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	phosphoglycolate phosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 230	230	Phosphoglycolate phosphatase HAMAP MF_00495		PRO_0000238172
Sites
	Active site	9	1	Nucleophile By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4FPT7-1 [UniParc]. Last modified August 30, 2005. Version 1. Checksum: AB48E503E22515B5	FASTA	230	25,142
	10 20 30 40 50 60 MDKQLLIFDF DGTLIDSVPD LADAVNAMLT TLGKAPYPID TIRNWVGNGS RMLVERALVG 70 80 90 100 110 120 KIEVSEGELA KETIDHAEQV FFDAYSKMGG SKTVAYPNVD SGLKKLKAAG FKLALVTNKP 130 140 150 160 170 180 IRFVPKILQF FGWHDIFSEV LGGDSLPTKK PDPAPLLHVC EVLNINPAQA VMIGDSINDI 190 200 210 220 230 LAGQNANMDT LGLSYGYNYG QDIRQLNPTE AFDDFSALVD YLLKAYPANN

References

[1]

"Complete sequence of Psychrobacter arcticum 273-4." NASA Astrobiology Institute Ayala-del-Rio H.L., Chain P., Ponder M.A., Di Bartolo G., Ivanova N., Bergholz P.W., Hauser L., Land M., Bakermans C., Rodrigues D., Klappenbach J.A., Zarka D., Larimer F., Richardson P., Thomashow M.F., Tiedje J.M. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000082 Genomic DNA. Translation: AAZ19971.1.
RefSeq	YP_265405.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3516112.
GenomeReviews	Gene locus Psyc_2124 in contig CP000082_GR.
KEGG	par:Psyc_2124.
NMPDR	fig|259536.4.peg.2096.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4FPT7.
OMA	Q4FPT7. AVCEQFS.
Enzyme and pathway databases
BioCyc	PARC259536:PSYC_2124-MON.
Family and domain databases
HAMAP	MF_00495. [Tree]
InterPro	IPR005834. Dehalogen-like_hydro. IPR006439. HAD-SF_hydro_IA_v1. IPR006402. HAD-SF_hydro_IA_v3. IPR005833. Haloacid_DH/epoxide_hydro. IPR006346. PGP_bact. [Graphical view]
Pfam	PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00413. HADHALOGNASE.
TIGRFAMs	TIGR01549. HAD-SF-IA-v1. 1 hit. TIGR01509. HAD-SF-IA-v3. 1 hit. TIGR01449. PGP_bact. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GPH_PSYA2

Accession

Primary (citable) accession number: Q4FPT7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	August 30, 2005
Last modified:	June 16, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)