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Q4FPE1 (Q4FPE1_PELUB) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
4-hydroxy-3-methylbut-2-enyl diphosphate reductase HAMAP MF_00191
EC=1.17.1.2 HAMAP MF_00191
Gene names
Name:lytB EMBL AAZ20948.1
Synonyms:ispH HAMAP MF_00191
Ordered Locus Names:SAR11_0124
OrganismPelagibacter ubique (strain HTCC1062) [Complete proteome] [HAMAP] EMBL AAZ20948.1
Taxonomic identifier335992 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › SAR11 cluster › Candidatus Pelagibacter

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) By similarity. HAMAP MF_00191

Catalytic activity

Dimethylallyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191

Isopentenyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191

Cofactor

Binds 1 3Fe-4S cluster By similarity. HAMAP MF_00191

Pathway

Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1. HAMAP MF_00191

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6. HAMAP MF_00191

Sequence similarities

Belongs to the IspH family. HAMAP MF_00191

Sequences

Sequence LengthMass (Da)Tools
Q4FPE1 [UniParc].

Last modified August 30, 2005. Version 1.
Checksum: 975635F1D32C5E53

FASTA31435,110
        10         20         30         40         50         60 
MKNKEIKILL SAPRGFCAGV ERAIEIVKKS ITKYGAPVYV RHEIVHNKHV VDSLKAIGAI 

        70         80         90        100        110        120 
FVEELDEIKD KSRPVIFSAH GVPKSVPQQA NGYKMEYIDA TCPLVSKVHR EAENLYKAGY 

       130        140        150        160        170        180 
HIVLIGHINH PEVIGTMGQL PEGSIDLIQD EHDVETYELD DNKKIAYVTQ TTLSVDDTKN 

       190        200        210        220        230        240 
IIKALKKKFP KIKEPFKEDI CYATTNRQSA VKNIAKKCDM FFVLGSRNSS NSVRLVEVAE 

       250        260        270        280        290        300 
QSGCPHSELI HSDSEIPFEK LENCKVIGIS SGASAPEILV ENFINEIKSK FKVKIETVEI 

       310 
IKENIVFKVP GKLN

« Hide

References

[1]"Genome streamlining in a cosmopolitan oceanic bacterium."
Giovannoni S.J., Tripp H.J., Givan S., Podar M., Vergin K.L., Baptista D., Bibbs L., Eads J., Richardson T.H., Noordewier M., Rappe M.S., Short J.M., Carrington J.C., Mathur E.J.
Science 309:1242-1245(2005) [PubMed: 16109880] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HTCC1062.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000084 Genomic DNA. Translation: AAZ20948.1.
RefSeqYP_265551.1. NC_007205.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3516738.
GenomeReviewsGene locus SAR11_0124 in contig CP000084_GR.
KEGGpub:SAR11_0124.
PATRIC31989709. VBICanPel5618_0125.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0761.
HOGENOMHBG335228.
OMAWGAPVYV.
PhylomeDBQ4FPE1.

Family and domain databases

HAMAPMF_00191. IspH.
[Tree]
InterProIPR003451. LytB.
[Graphical view]
KOK03527.
PfamPF02401. LYTB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00216. IspH_lytB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ4FPE1_PELUB
AccessionPrimary (citable) accession number: Q4FPE1
Entry history
Integrated into UniProtKB/TrEMBL: August 30, 2005
Last sequence update: August 30, 2005
Last modified: December 14, 2011
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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