Q4FP74 (GPMA_PELUB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase
Short name=BPG-dependent PGAM
Short name=PGAM
Short name=Phosphoglyceromutase
Short name=dPGM
EC=5.4.2.1

Gene names

Name:	gpmA
Ordered Locus Names:	SAR11_0193

Organism

Pelagibacter ubique (strain HTCC1062) [Complete proteome] [HAMAP]

Taxonomic identifier

335992 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › unclassified Alphaproteobacteria › SAR11 cluster › Candidatus Pelagibacter › Pelagibacter ubique

Protein attributes

Sequence length	238 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate By similarity. HAMAP-Rule MF_01039
Catalytic activity	2-phospho-D-glycerate = 3-phospho-D-glycerate. HAMAP-Rule MF_01039
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. HAMAP-Rule MF_01039
Sequence similarities	Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

Ontologies

Keywords
Biological process	Glycolysis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: HAMAP
Molecular_function	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 238	238	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase HAMAP-Rule MF_01039		PRO_0000229134
Sites
	Active site	9	1	Tele-phosphohistidine intermediate By similarity
	Active site	181	1	By similarity
	Site	60	1	Interaction with carboxyl group of phosphoglycerates By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4FP74 [UniParc]. Last modified August 30, 2005. Version 1. Checksum: 49AD3CA9E07B6358	FASTA	238	28,001
	10 20 30 40 50 60 MTHLILVRHG QSEWNLEKRF TGWVDVDLTG QGKLEACKAG EYIKETKIDI DYFYSSFQLR 70 80 90 100 110 120 AINTLKFIQD TLRDKREPVK AWQLNERHYG ALTGLNKDEM KEKLGEDKIH AFRRSWDIKP 130 140 150 160 170 180 DPLNRNNPYH PLNIEVYKSI PKENIPDTES LKDTYDRVMK FYIDEIQMKL KNDKNILISA 190 200 210 220 230 HGNSIRALCK FLFKLDNQRI TLLEIPTGNP LLINLDSKQN IKECTYLDQD RAKDLLVF

References

[1]

"Genome streamlining in a cosmopolitan oceanic bacterium." Giovannoni S.J., Tripp H.J., Givan S., Podar M., Vergin K.L., Baptista D., Bibbs L., Eads J., Richardson T.H., Noordewier M., Rappe M.S., Short J.M., Carrington J.C., Mathur E.J. Science 309:1242-1245(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HTCC1062.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000084 Genomic DNA. Translation: AAZ21015.1.
RefSeq	YP_265618.1. NC_007205.1.
3D structure databases
ProteinModelPortal	Q4FP74.
ModBase	Search...
Protein-protein interaction databases
STRING	335992.SAR11_0193.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAZ21015; AAZ21015; SAR11_0193.
GeneID	3516939.
KEGG	pub:SAR11_0193.
PATRIC	31989843. VBICanPel5618_0192.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0588.
HOGENOM	HOG000221682.
KO	K01834.
OMA	VYELDQA.
Enzyme and pathway databases
BioCyc	CPEL335992:GH3Z-191-MONOMER.
UniPathway	UPA00109; UER00186.
Family and domain databases
HAMAP	MF_01039. PGAM_GpmA.
InterPro	IPR013078. His_Pase_superF_clade-1. IPR001345. PG/BPGM_mutase_AS. IPR005952. Phosphogly_mut1. [Graphical view]
PANTHER	PTHR11931. PTHR11931. 1 hit.
Pfam	PF00300. His_Phos_1. 1 hit. [Graphical view]
SMART	SM00855. PGAM. 1 hit. [Graphical view]
TIGRFAMs	TIGR01258. pgm_1. 1 hit.
PROSITE	PS00175. PG_MUTASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPMA_PELUB

Accession

Primary (citable) accession number: Q4FP74

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	August 30, 2005
Last modified:	May 1, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program