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Q4FP45

- PROB_PELUB

UniProt

Q4FP45 - PROB_PELUB

Protein

Glutamate 5-kinase

Gene

proB

Organism
Pelagibacter ubique (strain HTCC1062)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (30 Aug 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.UniRule annotation

    Catalytic activityi

    ATP + L-glutamate = ADP + L-glutamate 5-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei12 – 121ATPUniRule annotation
    Binding sitei52 – 521SubstrateUniRule annotation
    Binding sitei139 – 1391SubstrateUniRule annotation
    Binding sitei151 – 1511Substrate; via amide nitrogenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi171 – 1722ATPUniRule annotation
    Nucleotide bindingi213 – 2197ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamate 5-kinase activity Source: UniProtKB-HAMAP
    3. RNA binding Source: InterPro

    GO - Biological processi

    1. L-proline biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Proline biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCPEL335992:GH3Z-222-MONOMER.
    UniPathwayiUPA00098; UER00359.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate 5-kinaseUniRule annotation (EC:2.7.2.11UniRule annotation)
    Alternative name(s):
    Gamma-glutamyl kinaseUniRule annotation
    Short name:
    GKUniRule annotation
    Gene namesi
    Name:proBUniRule annotation
    Ordered Locus Names:SAR11_0223
    OrganismiPelagibacter ubique (strain HTCC1062)
    Taxonomic identifieri335992 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSAR11 clusterCandidatus Pelagibacter
    ProteomesiUP000002528: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 368368Glutamate 5-kinasePRO_0000230051Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi335992.SAR11_0223.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4FP45.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini277 – 35478PUAUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glutamate 5-kinase family.UniRule annotation
    Contains 1 PUA domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0263.
    HOGENOMiHOG000246368.
    KOiK00931.
    OMAiRLMRAYE.
    OrthoDBiEOG6PGK7G.

    Family and domain databases

    Gene3Di2.30.130.10. 1 hit.
    3.40.1160.10. 1 hit.
    HAMAPiMF_00456. ProB.
    InterProiIPR001048. Asp/Glu/Uridylate_kinase.
    IPR001057. Glu/AcGlu_kinase.
    IPR011529. Glu_5kinase.
    IPR005715. Glu_5kinase/COase_Synthase.
    IPR019797. Glutamate_5-kinase_CS.
    IPR002478. PUA.
    IPR015947. PUA-like_domain.
    [Graphical view]
    PfamiPF00696. AA_kinase. 1 hit.
    PF01472. PUA. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000729. GK. 1 hit.
    PRINTSiPR00474. GLU5KINASE.
    SMARTiSM00359. PUA. 1 hit.
    [Graphical view]
    SUPFAMiSSF53633. SSF53633. 1 hit.
    SSF88697. SSF88697. 1 hit.
    TIGRFAMsiTIGR01027. proB. 1 hit.
    PROSITEiPS00902. GLUTAMATE_5_KINASE. 1 hit.
    PS50890. PUA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4FP45-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYLKDSKIIV IKIGSSLLID DKKKVRRKWL TEFAKDIQEL IKQNKKVIIV    50
    SSGAIAMGCK KLNISKKNLK IDKSQAVASI GQIELMNLFS ETFVKLKINI 100
    SQILLTLEDT EQRRRALNAK RTFDNLFKLG FVPIVNENDT IATSEIKYGD 150
    NDRLASRVAQ ISGADSLILL SDVDGLYTHN PKIYKNAKLI KEIRNIDKDI 200
    EKIATKSISE HGTGGMKTKI DAAKICQLSG CQMVIANGLV NRPIKKITEE 250
    NKCTWFLPKV SKLDARKKWI ISSVSPKGAL IIDDGAKQAL SNGKSLLAAG 300
    IKKVSGRFSK GDHIKVLDKN NYECARGLSS FSSNEIEKIM GHHSKEIEKL 350
    LGYISKSEVI HKDDIVEV 368
    Length:368
    Mass (Da):40,994
    Last modified:August 30, 2005 - v1
    Checksum:i4EE358A07F20895F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000084 Genomic DNA. Translation: AAZ21044.1.
    RefSeqiYP_265647.1. NC_007205.1.

    Genome annotation databases

    EnsemblBacteriaiAAZ21044; AAZ21044; SAR11_0223.
    GeneIDi3517551.
    KEGGipub:SAR11_0223.
    PATRICi31989901. VBICanPel5618_0221.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000084 Genomic DNA. Translation: AAZ21044.1 .
    RefSeqi YP_265647.1. NC_007205.1.

    3D structure databases

    ProteinModelPortali Q4FP45.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 335992.SAR11_0223.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ21044 ; AAZ21044 ; SAR11_0223 .
    GeneIDi 3517551.
    KEGGi pub:SAR11_0223.
    PATRICi 31989901. VBICanPel5618_0221.

    Phylogenomic databases

    eggNOGi COG0263.
    HOGENOMi HOG000246368.
    KOi K00931.
    OMAi RLMRAYE.
    OrthoDBi EOG6PGK7G.

    Enzyme and pathway databases

    UniPathwayi UPA00098 ; UER00359 .
    BioCyci CPEL335992:GH3Z-222-MONOMER.

    Family and domain databases

    Gene3Di 2.30.130.10. 1 hit.
    3.40.1160.10. 1 hit.
    HAMAPi MF_00456. ProB.
    InterProi IPR001048. Asp/Glu/Uridylate_kinase.
    IPR001057. Glu/AcGlu_kinase.
    IPR011529. Glu_5kinase.
    IPR005715. Glu_5kinase/COase_Synthase.
    IPR019797. Glutamate_5-kinase_CS.
    IPR002478. PUA.
    IPR015947. PUA-like_domain.
    [Graphical view ]
    Pfami PF00696. AA_kinase. 1 hit.
    PF01472. PUA. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000729. GK. 1 hit.
    PRINTSi PR00474. GLU5KINASE.
    SMARTi SM00359. PUA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53633. SSF53633. 1 hit.
    SSF88697. SSF88697. 1 hit.
    TIGRFAMsi TIGR01027. proB. 1 hit.
    PROSITEi PS00902. GLUTAMATE_5_KINASE. 1 hit.
    PS50890. PUA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HTCC1062.

    Entry informationi

    Entry nameiPROB_PELUB
    AccessioniPrimary (citable) accession number: Q4FP45
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: August 30, 2005
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3