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Protein

Probable nicotinate-nucleotide adenylyltransferase

Gene

nadD

Organism
Pelagibacter ubique (strain HTCC1062)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).UniRule annotation

Catalytic activityi

ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD+.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes deamido-NAD(+) from nicotinate D-ribonucleotide.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable nicotinate-nucleotide adenylyltransferase (nadD)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes deamido-NAD(+) from nicotinate D-ribonucleotide, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processPyridine nucleotide biosynthesis
LigandATP-binding, NAD, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPEL335992:G1G4O-226-MONOMER
UniPathwayiUPA00253; UER00332

Names & Taxonomyi

Protein namesi
Recommended name:
Probable nicotinate-nucleotide adenylyltransferaseUniRule annotation (EC:2.7.7.18UniRule annotation)
Alternative name(s):
Deamido-NAD(+) diphosphorylaseUniRule annotation
Deamido-NAD(+) pyrophosphorylaseUniRule annotation
Nicotinate mononucleotide adenylyltransferaseUniRule annotation
Short name:
NaMN adenylyltransferaseUniRule annotation
Gene namesi
Name:nadDUniRule annotation
Ordered Locus Names:SAR11_0225
OrganismiPelagibacter ubique (strain HTCC1062)
Taxonomic identifieri335992 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaPelagibacteralesPelagibacteraceaeCandidatus Pelagibacter
Proteomesi
  • UP000002528 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003367171 – 180Probable nicotinate-nucleotide adenylyltransferaseAdd BLAST180

Interactioni

Protein-protein interaction databases

STRINGi335992.SAR11_0225

Structurei

3D structure databases

ProteinModelPortaliQ4FP43
SMRiQ4FP43
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NadD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107WK2 Bacteria
COG1057 LUCA
KOiK00969
OMAiIHIGHLI
OrthoDBiPOG091H028Y

Family and domain databases

CDDicd02165 NMNAT, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00244 NaMN_adenylyltr, 1 hit
InterProiView protein in InterPro
IPR004821 Cyt_trans-like
IPR005248 NadD/NMNAT
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF01467 CTP_transf_like, 1 hit
TIGRFAMsiTIGR00125 cyt_tran_rel, 1 hit
TIGR00482 TIGR00482, 1 hit

Sequencei

Sequence statusi: Complete.

Q4FP43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKPENNLNQ KKTKIGILGG TFDPAHKGHL EISKQAKKIL ELKNIIWAIT
60 70 80 90 100
KQNPFKNTSK TDLKNRIKFA KKIIGKNNFI KVKFYEEKVL SNKTIDLINY
110 120 130 140 150
LNKDKKFEIY FIMGADNLIN FHKWYKWKSI IKKCNLLVFD RQGYKAKSLK
160 170 180
SVTYNGVNKN RLSFINFKKV NISSSQLRKI
Length:180
Mass (Da):21,099
Last modified:August 30, 2005 - v1
Checksum:iB7B23DD10DAD127F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000084 Genomic DNA Translation: AAZ21046.1
RefSeqiWP_011281554.1, NC_007205.1

Genome annotation databases

EnsemblBacteriaiAAZ21046; AAZ21046; SAR11_0225
KEGGipub:SAR11_0225

Similar proteinsi

Entry informationi

Entry nameiNADD_PELUB
AccessioniPrimary (citable) accession number: Q4FP43
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 30, 2005
Last modified: February 28, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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