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Q4FP43 (NADD_PELUB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable nicotinate-nucleotide adenylyltransferase

EC=2.7.7.18
Alternative name(s):
Deamido-NAD(+) diphosphorylase
Deamido-NAD(+) pyrophosphorylase
Nicotinate mononucleotide adenylyltransferase
Short name=NaMN adenylyltransferase
Gene names
Name:nadD
Ordered Locus Names:SAR11_0225
OrganismPelagibacter ubique (strain HTCC1062) [Complete proteome] [HAMAP]
Taxonomic identifier335992 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaSAR11 clusterCandidatus Pelagibacter

Protein attributes

Sequence length180 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) By similarity. HAMAP-Rule MF_00244

Catalytic activity

ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD+. HAMAP-Rule MF_00244

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1. HAMAP-Rule MF_00244

Sequence similarities

Belongs to the NadD family.

Ontologies

Keywords
   Biological processPyridine nucleotide biosynthesis
   LigandATP-binding
NAD
Nucleotide-binding
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processNAD biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

nicotinate-nucleotide adenylyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 180180Probable nicotinate-nucleotide adenylyltransferase HAMAP-Rule MF_00244
PRO_0000336717

Sequences

Sequence LengthMass (Da)Tools
Q4FP43 [UniParc].

Last modified August 30, 2005. Version 1.
Checksum: B7B23DD10DAD127F

FASTA18021,099
        10         20         30         40         50         60 
MVKPENNLNQ KKTKIGILGG TFDPAHKGHL EISKQAKKIL ELKNIIWAIT KQNPFKNTSK 

        70         80         90        100        110        120 
TDLKNRIKFA KKIIGKNNFI KVKFYEEKVL SNKTIDLINY LNKDKKFEIY FIMGADNLIN 

       130        140        150        160        170        180 
FHKWYKWKSI IKKCNLLVFD RQGYKAKSLK SVTYNGVNKN RLSFINFKKV NISSSQLRKI 

« Hide

References

[1]"Genome streamlining in a cosmopolitan oceanic bacterium."
Giovannoni S.J., Tripp H.J., Givan S., Podar M., Vergin K.L., Baptista D., Bibbs L., Eads J., Richardson T.H., Noordewier M., Rappe M.S., Short J.M., Carrington J.C., Mathur E.J.
Science 309:1242-1245(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HTCC1062.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000084 Genomic DNA. Translation: AAZ21046.1.
RefSeqYP_265649.1. NC_007205.1.

3D structure databases

ProteinModelPortalQ4FP43.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING335992.SAR11_0225.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAZ21046; AAZ21046; SAR11_0225.
GeneID3517553.
KEGGpub:SAR11_0225.
PATRIC31989905. VBICanPel5618_0223.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1057.
KOK00969.
OMAPHYGHLY.
OrthoDBEOG6F55KJ.

Enzyme and pathway databases

BioCycCPEL335992:GH3Z-224-MONOMER.
UniPathwayUPA00253; UER00332.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00244. NaMN_adenylyltr.
InterProIPR004821. Cyt_trans-like.
IPR005248. NAMN_adtrnsfrase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamPF01467. CTP_transf_2. 1 hit.
[Graphical view]
TIGRFAMsTIGR00125. cyt_tran_rel. 1 hit.
TIGR00482. TIGR00482. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADD_PELUB
AccessionPrimary (citable) accession number: Q4FP43
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 30, 2005
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways