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Q4FP28

- MDH_PELUB

UniProt

Q4FP28 - MDH_PELUB

Protein

Malate dehydrogenase

Gene

mdh

Organism
Pelagibacter ubique (strain HTCC1062)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (30 Aug 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei33 – 331NADUniRule annotation
    Binding sitei82 – 821SubstrateUniRule annotation
    Binding sitei88 – 881SubstrateUniRule annotation
    Binding sitei95 – 951NADUniRule annotation
    Binding sitei120 – 1201SubstrateUniRule annotation
    Binding sitei151 – 1511SubstrateUniRule annotation
    Active sitei175 – 1751Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi8 – 136NADUniRule annotation
    Nucleotide bindingi118 – 1203NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciCPEL335992:GH3Z-239-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdhUniRule annotation
    Ordered Locus Names:SAR11_0240
    OrganismiPelagibacter ubique (strain HTCC1062)
    Taxonomic identifieri335992 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSAR11 clusterCandidatus Pelagibacter
    ProteomesiUP000002528: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 320320Malate dehydrogenasePRO_0000241957Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi335992.SAR11_0240.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4FP28.
    SMRiQ4FP28. Positions 2-309.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0039.
    HOGENOMiHOG000213794.
    KOiK00024.
    OMAiYGQNDIC.
    OrthoDBiEOG6091FG.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_00487. Malate_dehydrog_3.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSiPR00086. LLDHDRGNASE.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q4FP28-1 [UniParc]FASTAAdd to Basket

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    MKKISLIGAG QIGGTLAHLI GTKEVADEVV LFDVASGIAK GKALDIAQSS    50
    SVDGFNVKFS GTDNYEDIKD SDVIIITAGV PRKPGMSRDD LLGINLKIIK 100
    QVAEGIKKNA PNAFVICITN PLDVMVMAFQ KFSGLPANKV VGMAGILDSS 150
    RFKLFLSLEL NVPVKEIEAM VMGGHGDTMV PLPRFTKVSG KPLLDLVKEG 200
    KISPERLEEI NQRTRDGGAE IVKYLEKGSA FYAPAASGVQ MAEAYLKDEK 250
    KLLPCAVHLN GEYGVSNVYA GVPVIIGKDG VEKIEQIDLD EKEKKEFMHS 300
    IDAVKALWEA ASKIDPDLSK 320
    Length:320
    Mass (Da):34,427
    Last modified:August 30, 2005 - v1
    Checksum:iA02982E95921F997
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000084 Genomic DNA. Translation: AAZ21061.1.
    RefSeqiWP_011281563.1. NC_007205.1.
    YP_265664.1. NC_007205.1.

    Genome annotation databases

    EnsemblBacteriaiAAZ21061; AAZ21061; SAR11_0240.
    GeneIDi3517568.
    KEGGipub:SAR11_0240.
    PATRICi31989935. VBICanPel5618_0238.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000084 Genomic DNA. Translation: AAZ21061.1 .
    RefSeqi WP_011281563.1. NC_007205.1.
    YP_265664.1. NC_007205.1.

    3D structure databases

    ProteinModelPortali Q4FP28.
    SMRi Q4FP28. Positions 2-309.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 335992.SAR11_0240.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ21061 ; AAZ21061 ; SAR11_0240 .
    GeneIDi 3517568.
    KEGGi pub:SAR11_0240.
    PATRICi 31989935. VBICanPel5618_0238.

    Phylogenomic databases

    eggNOGi COG0039.
    HOGENOMi HOG000213794.
    KOi K00024.
    OMAi YGQNDIC.
    OrthoDBi EOG6091FG.

    Enzyme and pathway databases

    BioCyci CPEL335992:GH3Z-239-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_00487. Malate_dehydrog_3.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSi PR00086. LLDHDRGNASE.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HTCC1062.

    Entry informationi

    Entry nameiMDH_PELUB
    AccessioniPrimary (citable) accession number: Q4FP28
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: August 30, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3