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Q4FP28

- MDH_PELUB

UniProt

Q4FP28 - MDH_PELUB

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Protein
Malate dehydrogenase
Gene
mdh, SAR11_0240
Organism
Pelagibacter ubique (strain HTCC1062)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331NAD By similarity
Binding sitei82 – 821Substrate By similarity
Binding sitei88 – 881Substrate By similarity
Binding sitei95 – 951NAD By similarity
Binding sitei120 – 1201Substrate By similarity
Binding sitei151 – 1511Substrate By similarity
Active sitei175 – 1751Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 136NAD By similarity
Nucleotide bindingi118 – 1203NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciCPEL335992:GH3Z-239-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
Ordered Locus Names:SAR11_0240
OrganismiPelagibacter ubique (strain HTCC1062)
Taxonomic identifieri335992 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSAR11 clusterCandidatus Pelagibacter
ProteomesiUP000002528: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320Malate dehydrogenaseUniRule annotation
PRO_0000241957Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi335992.SAR11_0240.

Structurei

3D structure databases

ProteinModelPortaliQ4FP28.
SMRiQ4FP28. Positions 2-309.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213794.
KOiK00024.
OMAiYGQNDIC.
OrthoDBiEOG6091FG.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4FP28-1 [UniParc]FASTAAdd to Basket

« Hide

MKKISLIGAG QIGGTLAHLI GTKEVADEVV LFDVASGIAK GKALDIAQSS    50
SVDGFNVKFS GTDNYEDIKD SDVIIITAGV PRKPGMSRDD LLGINLKIIK 100
QVAEGIKKNA PNAFVICITN PLDVMVMAFQ KFSGLPANKV VGMAGILDSS 150
RFKLFLSLEL NVPVKEIEAM VMGGHGDTMV PLPRFTKVSG KPLLDLVKEG 200
KISPERLEEI NQRTRDGGAE IVKYLEKGSA FYAPAASGVQ MAEAYLKDEK 250
KLLPCAVHLN GEYGVSNVYA GVPVIIGKDG VEKIEQIDLD EKEKKEFMHS 300
IDAVKALWEA ASKIDPDLSK 320
Length:320
Mass (Da):34,427
Last modified:August 30, 2005 - v1
Checksum:iA02982E95921F997
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000084 Genomic DNA. Translation: AAZ21061.1.
RefSeqiWP_011281563.1. NC_007205.1.
YP_265664.1. NC_007205.1.

Genome annotation databases

EnsemblBacteriaiAAZ21061; AAZ21061; SAR11_0240.
GeneIDi3517568.
KEGGipub:SAR11_0240.
PATRICi31989935. VBICanPel5618_0238.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000084 Genomic DNA. Translation: AAZ21061.1 .
RefSeqi WP_011281563.1. NC_007205.1.
YP_265664.1. NC_007205.1.

3D structure databases

ProteinModelPortali Q4FP28.
SMRi Q4FP28. Positions 2-309.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 335992.SAR11_0240.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ21061 ; AAZ21061 ; SAR11_0240 .
GeneIDi 3517568.
KEGGi pub:SAR11_0240.
PATRICi 31989935. VBICanPel5618_0238.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000213794.
KOi K00024.
OMAi YGQNDIC.
OrthoDBi EOG6091FG.

Enzyme and pathway databases

BioCyci CPEL335992:GH3Z-239-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HTCC1062.

Entry informationi

Entry nameiMDH_PELUB
AccessioniPrimary (citable) accession number: Q4FP28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: August 30, 2005
Last modified: September 3, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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