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Q4FNI5 (UPPP_PELUB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA
Ordered Locus Names:SAR11_0432
OrganismPelagibacter ubique (strain HTCC1062) [Complete proteome] [HAMAP]
Taxonomic identifier335992 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaSAR11 clusterCandidatus Pelagibacter

Protein attributes

Sequence length256 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 256256Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000227623

Regions

Transmembrane5 – 2521Helical; Potential
Transmembrane41 – 6121Helical; Potential
Transmembrane74 – 9421Helical; Potential
Transmembrane100 – 12021Helical; Potential
Transmembrane135 – 15521Helical; Potential
Transmembrane180 – 20021Helical; Potential
Transmembrane208 – 22821Helical; Potential
Transmembrane234 – 25421Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q4FNI5 [UniParc].

Last modified August 30, 2005. Version 1.
Checksum: 428F59FBFC3AC2AD

FASTA25628,820
        10         20         30         40         50         60 
MFSNIIEIII LSIVQGISEF LPISSSAHLN IVEIIFEFNS NSLMIDVSLH LGSLLAIVFY 

        70         80         90        100        110        120 
FRRELLDLRN NQKLLSLLII GSIPIVIAGY VISSTGLVNL LENNLKIIAW TTLIFGIILY 

       130        140        150        160        170        180 
LADKSKFDKK ISSNLNFKTI LYIGLFQILA LIPGVSRAGI TITAARLFRF NRFDSSKISF 

       190        200        210        220        230        240 
LLAIPAIAGA SVLQLKNAIG QSFELNYLVL ISITLSFLFS YFTVKFFLDY INKFSLNVFV 

       250 
IYRIIISIIL FIIIYN 

« Hide

References

[1]"Genome streamlining in a cosmopolitan oceanic bacterium."
Giovannoni S.J., Tripp H.J., Givan S., Podar M., Vergin K.L., Baptista D., Bibbs L., Eads J., Richardson T.H., Noordewier M., Rappe M.S., Short J.M., Carrington J.C., Mathur E.J.
Science 309:1242-1245(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HTCC1062.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000084 Genomic DNA. Translation: AAZ21254.1.
RefSeqYP_265857.1. NC_007205.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING335992.SAR11_0432.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAZ21254; AAZ21254; SAR11_0432.
GeneID3517266.
KEGGpub:SAR11_0432.
PATRIC31990327. VBICanPel5618_0431.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAMEIGTIF.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycCPEL335992:GH3Z-435-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_PELUB
AccessionPrimary (citable) accession number: Q4FNI5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: August 30, 2005
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families