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Q4FNF2 (ARGB_PELUB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetylglutamate kinase

EC=2.7.2.8
Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferase
NAG kinase
Short name=AGK
Gene names
Name:argB
Ordered Locus Names:SAR11_0465
OrganismPelagibacter ubique (strain HTCC1062) [Complete proteome] [HAMAP]
Taxonomic identifier335992 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaSAR11 clusterCandidatus Pelagibacter

Protein attributes

Sequence length288 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP-Rule MF_00082

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP-Rule MF_00082

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00082.

Sequence similarities

Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

proline biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

acetylglutamate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glutamate 5-kinase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 288288Acetylglutamate kinase HAMAP-Rule MF_00082
PRO_0000264728

Regions

Region73 – 742Substrate binding By similarity

Sites

Binding site951Substrate By similarity
Binding site1861Substrate By similarity
Site381Transition state stabilizer By similarity
Site2461Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4FNF2 [UniParc].

Last modified August 30, 2005. Version 1.
Checksum: DE374EB344751582

FASTA28831,886
        10         20         30         40         50         60 
MSSLREEELI NILPKDGPTV EEVKKYLEKY NDEFIIIKCG GSVLVDPKLF KVFIEDVVVL 

        70         80         90        100        110        120 
KKLGFNPIIV HGGGKRINSK LLEVNIKSNF INGLRVTDKD TINIVEDVLI EFNKEIVEAL 

       130        140        150        160        170        180 
NELDCKAKRI TSKENNIITV VQENKDLGFV GRPTGINKEF LTEIIKANKV PVIAPLGLDK 

       190        200        210        220        230        240 
DNQTFNINAD TTAGSIAIEL KARRLMIISD VEGVLDSEKK LIPEINSKKA NELIDQEVIS 

       250        260        270        280 
GGMIPKIKNC LDVASNGVKA VVIIDGRKNH SLLFELLSDK GSGTLIRE 

« Hide

References

[1]"Genome streamlining in a cosmopolitan oceanic bacterium."
Giovannoni S.J., Tripp H.J., Givan S., Podar M., Vergin K.L., Baptista D., Bibbs L., Eads J., Richardson T.H., Noordewier M., Rappe M.S., Short J.M., Carrington J.C., Mathur E.J.
Science 309:1242-1245(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HTCC1062.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000084 Genomic DNA. Translation: AAZ21287.1.
RefSeqYP_265890.1. NC_007205.1.

3D structure databases

ProteinModelPortalQ4FNF2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING335992.SAR11_0465.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAZ21287; AAZ21287; SAR11_0465.
GeneID3517227.
KEGGpub:SAR11_0465.
PATRIC31990395. VBICanPel5618_0464.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0548.
HOGENOMHOG000233259.
KOK00930.
OMAETFVIKY.
OrthoDBEOG6T1WVF.

Enzyme and pathway databases

BioCycCPEL335992:GH3Z-469-MONOMER.
UniPathwayUPA00068; UER00107.

Family and domain databases

Gene3D3.40.1160.10. 1 hit.
HAMAPMF_00082_B. ArgB_B.
InterProIPR004662. AcgluKinase.
IPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
[Graphical view]
PfamPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFPIRSF000728. NAGK. 1 hit.
PRINTSPR00474. GLU5KINASE.
SUPFAMSSF53633. SSF53633. 1 hit.
TIGRFAMsTIGR00761. argB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameARGB_PELUB
AccessionPrimary (citable) accession number: Q4FNF2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: August 30, 2005
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways