Q4FNF2 (ARGB_PELUB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylglutamate kinase
EC=2.7.2.8

Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferase
NAG kinase
Short name=AGK

Gene names

Name:	argB
Ordered Locus Names:	SAR11_0465

Organism

Pelagibacter ubique (strain HTCC1062) [Complete proteome] [HAMAP]

Taxonomic identifier

335992 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › unclassified Alphaproteobacteria › SAR11 cluster › Candidatus Pelagibacter › Pelagibacter ubique

Protein attributes

Sequence length	288 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP-Rule MF_00082
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP-Rule MF_00082
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP proline biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP acetylglutamate kinase activity Inferred from electronic annotation. Source: HAMAP glutamate 5-kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 288	288	Acetylglutamate kinase HAMAP-Rule MF_00082		PRO_0000264728
Regions
	Region	73 – 74	2	Substrate binding By similarity
Sites
	Binding site	95	1	Substrate By similarity
	Binding site	186	1	Substrate By similarity
	Site	38	1	Transition state stabilizer By similarity
	Site	246	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4FNF2 [UniParc]. Last modified August 30, 2005. Version 1. Checksum: DE374EB344751582	FASTA	288	31,886
	10 20 30 40 50 60 MSSLREEELI NILPKDGPTV EEVKKYLEKY NDEFIIIKCG GSVLVDPKLF KVFIEDVVVL 70 80 90 100 110 120 KKLGFNPIIV HGGGKRINSK LLEVNIKSNF INGLRVTDKD TINIVEDVLI EFNKEIVEAL 130 140 150 160 170 180 NELDCKAKRI TSKENNIITV VQENKDLGFV GRPTGINKEF LTEIIKANKV PVIAPLGLDK 190 200 210 220 230 240 DNQTFNINAD TTAGSIAIEL KARRLMIISD VEGVLDSEKK LIPEINSKKA NELIDQEVIS 250 260 270 280 GGMIPKIKNC LDVASNGVKA VVIIDGRKNH SLLFELLSDK GSGTLIRE

References

[1]

"Genome streamlining in a cosmopolitan oceanic bacterium." Giovannoni S.J., Tripp H.J., Givan S., Podar M., Vergin K.L., Baptista D., Bibbs L., Eads J., Richardson T.H., Noordewier M., Rappe M.S., Short J.M., Carrington J.C., Mathur E.J. Science 309:1242-1245(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HTCC1062.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000084 Genomic DNA. Translation: AAZ21287.1.
RefSeq	YP_265890.1. NC_007205.1.
3D structure databases
HSSP	HSSP built from PDB template 2BTY based on UniProtKB Q9X2A4.
ProteinModelPortal	Q4FNF2.
ModBase	Search...
Protein-protein interaction databases
STRING	335992.SAR11_0465.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAZ21287; AAZ21287; SAR11_0465.
GeneID	3517227.
KEGG	pub:SAR11_0465.
PATRIC	31990395. VBICanPel5618_0464.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0548.
HOGENOM	HOG000233259.
KO	K00930.
OMA	GNMVFAE.
Enzyme and pathway databases
BioCyc	CPEL335992:GH3Z-463-MONOMER.
UniPathway	UPA00068; UER00107.
Family and domain databases
Gene3D	3.40.1160.10. 1 hit.
HAMAP	MF_00082_B. ArgB_B.
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. IPR001057. Glu/AcGlu_kinase. [Graphical view]
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
PRINTS	PR00474. GLU5KINASE.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00761. argB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_PELUB

Accession

Primary (citable) accession number: Q4FNF2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	August 30, 2005
Last modified:	May 1, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program