Reviewed, UniProtKB/Swiss-Prot Q4FNE2 (HISX1_PELUB)

Names and origin

Protein names

Recommended name:
    Histidinol dehydrogenase 1
      Short name=HDH 1
    EC=1.1.1.23

Gene names

Name:	hisD1
Ordered Locus Names:	SAR11_0475

Organism

Pelagibacter ubique [Complete proteome] [HAMAP]

Taxonomic identifier

335992 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › SAR11 cluster › Candidatus Pelagibacter

Protein attributes

Sequence length	428 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.
Catalytic activity	L-histidinol + 2 NAD(+) = L-histidine + 2 NADH. HAMAP MF_01024
Cofactor	Binds 1 zinc ion per subunit By similarity.
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP MF_01024
Sequence similarities	Belongs to the histidinol dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro histidinol dehydrogenase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 428	428	Histidinol dehydrogenase 1 HAMAP MF_01024		PRO_0000135809
Sites
	Active site	324	1	Proton acceptor By similarity
	Active site	325	1	Proton acceptor By similarity
	Metal binding	256	1	Zinc By similarity
	Metal binding	259	1	Zinc By similarity
	Metal binding	358	1	Zinc By similarity
	Metal binding	417	1	Zinc By similarity
	Binding site	234	1	Substrate By similarity
	Binding site	256	1	Substrate By similarity
	Binding site	259	1	Substrate By similarity
	Binding site	325	1	Substrate By similarity
	Binding site	358	1	Substrate By similarity
	Binding site	412	1	Substrate By similarity
	Binding site	417	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4FNE2-1 [UniParc]. Last modified August 30, 2005. Version 1. Checksum: 87F54F17177A8658	FASTA	428	47,310
	10 20 30 40 50 60 MIKILDSKNK NFDKTLDALL SKRKNKVQLN SVSVIKIIKD VKKNGDKAIL KYEKRFNKNS 70 80 90 100 110 120 IIAPSIKQIN RAIQSLDQKV KKAIDLAYDR IYKFHSLQKF KNISYTDKLK NKLEYKYVPI 130 140 150 160 170 180 ESVAIYVPGS TASYPSSVLM NAVPAIVAGV KRLVMVNPGQ KGKQNPAVLY AAKKCKIKEI 190 200 210 220 230 240 YSIGGPSAIA AVAYGTKKIK KVDKIIGPGN SYVAAAKKEV FGDVGIEGMI AGPSEVTIVC 250 260 270 280 290 300 DKFSNPEWIA SDLIGQAEHD NLAQCILISK DKSIIKKVNY EIINQLKELP RAVIAKNSLL 310 320 330 340 350 360 NNGILIYMPS DQKIINTVNK IAPEHLELNT KNYKKVVSKI KNAGSICLGK YAVMAMTDYN 370 380 390 400 410 420 VGSNHVLPTN SSARYSSGVS VNEFYKRISY INLSKKGIET LGPSVITLAN YEGLVGHAKS VEKRIRRK

References

[1]

"Genome streamlining in a cosmopolitan oceanic bacterium." Giovannoni S.J., Tripp H.J., Givan S., Podar M., Vergin K.L., Baptista D., Bibbs L., Eads J., Richardson T.H., Noordewier M., Rappe M.S., Short J.M., Carrington J.C., Mathur E.J. Science 309:1242-1245(2005) [PubMed: 16109880] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HTCC1062.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000084 Genomic DNA. Translation: AAZ21297.1.
RefSeq	YP_265900.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3517238.
GenomeReviews	Gene locus SAR11_0475 in contig CP000084_GR.
KEGG	pub:SAR11_0475.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4FNE2.
Enzyme and pathway databases
BioCyc	CPEL335992:SAR11_0475-MON.
Family and domain databases
HAMAP	MF_01024. [Tree]
InterPro	IPR001692. Histidinol_DHase. IPR012131. Hstdl_DHase_prok. [Graphical view]
PANTHER	PTHR21256:SF2. Hstdl_DH_prok. 1 hit.
Pfam	PF00815. Histidinol_dh. 1 hit. [Graphical view]
PRINTS	PR00083. HOLDHDRGNASE.
ProDom	PD002680. Histidinol_dh. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00069. hisD. 1 hit.
PROSITE	PS00611. HISOL_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HISX1_PELUB

Accession

Primary (citable) accession number: Q4FNE2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	August 30, 2005
Last modified:	November 25, 2008
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)