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Q4FNE2

- HISX1_PELUB

UniProt

Q4FNE2 - HISX1_PELUB

Protein

Histidinol dehydrogenase 1

Gene

hisD1

Organism
Pelagibacter ubique (strain HTCC1062)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (30 Aug 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei234 – 2341SubstrateUniRule annotation
    Metal bindingi256 – 2561ZincUniRule annotation
    Binding sitei256 – 2561SubstrateUniRule annotation
    Metal bindingi259 – 2591ZincUniRule annotation
    Binding sitei259 – 2591SubstrateUniRule annotation
    Active sitei324 – 3241Proton acceptorUniRule annotation
    Active sitei325 – 3251Proton acceptorUniRule annotation
    Binding sitei325 – 3251SubstrateUniRule annotation
    Metal bindingi358 – 3581ZincUniRule annotation
    Binding sitei358 – 3581SubstrateUniRule annotation
    Binding sitei412 – 4121SubstrateUniRule annotation
    Metal bindingi417 – 4171ZincUniRule annotation
    Binding sitei417 – 4171SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciCPEL335992:GH3Z-481-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenase 1UniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDH 1UniRule annotation
    Gene namesi
    Name:hisD1UniRule annotation
    Ordered Locus Names:SAR11_0475
    OrganismiPelagibacter ubique (strain HTCC1062)
    Taxonomic identifieri335992 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSAR11 clusterCandidatus Pelagibacter
    ProteomesiUP000002528: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 428428Histidinol dehydrogenase 1PRO_0000135809Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi335992.SAR11_0475.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4FNE2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiYAAKLCG.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4FNE2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIKILDSKNK NFDKTLDALL SKRKNKVQLN SVSVIKIIKD VKKNGDKAIL    50
    KYEKRFNKNS IIAPSIKQIN RAIQSLDQKV KKAIDLAYDR IYKFHSLQKF 100
    KNISYTDKLK NKLEYKYVPI ESVAIYVPGS TASYPSSVLM NAVPAIVAGV 150
    KRLVMVNPGQ KGKQNPAVLY AAKKCKIKEI YSIGGPSAIA AVAYGTKKIK 200
    KVDKIIGPGN SYVAAAKKEV FGDVGIEGMI AGPSEVTIVC DKFSNPEWIA 250
    SDLIGQAEHD NLAQCILISK DKSIIKKVNY EIINQLKELP RAVIAKNSLL 300
    NNGILIYMPS DQKIINTVNK IAPEHLELNT KNYKKVVSKI KNAGSICLGK 350
    YAVMAMTDYN VGSNHVLPTN SSARYSSGVS VNEFYKRISY INLSKKGIET 400
    LGPSVITLAN YEGLVGHAKS VEKRIRRK 428
    Length:428
    Mass (Da):47,310
    Last modified:August 30, 2005 - v1
    Checksum:i87F54F17177A8658
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000084 Genomic DNA. Translation: AAZ21297.1.
    RefSeqiYP_265900.1. NC_007205.1.

    Genome annotation databases

    EnsemblBacteriaiAAZ21297; AAZ21297; SAR11_0475.
    GeneIDi3517238.
    KEGGipub:SAR11_0475.
    PATRICi31990417. VBICanPel5618_0474.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000084 Genomic DNA. Translation: AAZ21297.1 .
    RefSeqi YP_265900.1. NC_007205.1.

    3D structure databases

    ProteinModelPortali Q4FNE2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 335992.SAR11_0475.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ21297 ; AAZ21297 ; SAR11_0475 .
    GeneIDi 3517238.
    KEGGi pub:SAR11_0475.
    PATRICi 31990417. VBICanPel5618_0474.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi YAAKLCG.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci CPEL335992:GH3Z-481-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HTCC1062.

    Entry informationi

    Entry nameiHISX1_PELUB
    AccessioniPrimary (citable) accession number: Q4FNE2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: August 30, 2005
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3