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Q4FMV1

- GCSP_PELUB

UniProt

Q4FMV1 - GCSP_PELUB

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Pelagibacter ubique (strain HTCC1062)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciCPEL335992:GH3Z-680-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:SAR11_0668
OrganismiPelagibacter ubique (strain HTCC1062)
Taxonomic identifieri335992 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSAR11 clusterCandidatus Pelagibacter
ProteomesiUP000002528: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 952952Glycine dehydrogenase (decarboxylating)PRO_0000227111Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei696 – 6961N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi335992.SAR11_0668.

Structurei

3D structure databases

ProteinModelPortaliQ4FMV1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4FMV1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLKNAQKDFI QRHIGPSVDE QNVMLKELGY QNLDDLIKDT VPEKILLKDD
60 70 80 90 100
LDIGDPNSEY KALRKLKDIS KKNKIYSSFI GMGYYGTYTP YVILRNILEN
110 120 130 140 150
PGWYTSYTPY QPEVAQGRLE MLLNFQQMII DFTGMDIANA SLLDEGTAAA
160 170 180 190 200
EAMGLSYRIS KSESKKVFVS KNCHPQTIDV IKTRAEPLGL EIIVGDEDKD
210 220 230 240 250
IKEDIICGII QYPGTLGDIK DPSEAISKIH KFNGKAVLAC DLLALAKLKT
260 270 280 290 300
PAELGADIAV GSSQRFGIPM GYGGPHAAFF ATKDEYKRSM PGRIVGVSVD
310 320 330 340 350
RHGKKAYRLA LQTREQHIRR DKATSNICTA QALLAIVSAA YAVYHGPQGI
360 370 380 390 400
KKIAESVSQL TKNFADKLKQ SGYELYSNEF FDTVTIKTLD KTEKIYKNAL
410 420 430 440 450
DQGVNIRKVN SEMLAVSFDE RKNLYRANQL LKIFNCSETI KETMNESLSN
460 470 480 490 500
IPKNLLRTST YLDHPVFNSY HSETEMLRYL KKLEDSDIAL NKSMIALGSC
510 520 530 540 550
TMKLNAVAEM IPVTWKEFSQ PHPFSPVEQM DGYRELFTDL KNWLRSITGF
560 570 580 590 600
SGVSLQPNAG AQGEFAGLMV IRKFHEKNGE TNRNVCLIPS SAHGTNPASA
610 620 630 640 650
QMVGMKVVVV KCDQYGNVDY EDLKNKAEEH SENLAALMVT YPSTHGVFEE
660 670 680 690 700
KITDICELIH NHGGQVYMDG ANLNALVGIA KPGNFGPDVC HINLHKTFCI
710 720 730 740 750
PHGGGGPGMG PIACKKHLEI FLPKHSVIKD CGPVTGMGAV SAAPWGSSSI
760 770 780 790 800
LSISWMYIKM MGSEGLRKAS QVAILNANYI AHKLKDSFPI LYKGKSGNVA
810 820 830 840 850
HECIIDIRTI KSETGITEED IAKRLIDFGY HAPTMSWPVA GTMMIEPTES
860 870 880 890 900
ESLSEIDKFC STLIKIKQEI DKIQSGEYDK TDNPLKNAPH THVELTSNKW
910 920 930 940 950
DHKYEREEAA YPSEFLRTNK YWPPVGRVDN VYGDKNLFCT CPSMEEYEDT

AA
Length:952
Mass (Da):106,007
Last modified:August 30, 2005 - v1
Checksum:i106AE6F72ABC7B87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000084 Genomic DNA. Translation: AAZ21488.1.
RefSeqiYP_266091.1. NC_007205.1.

Genome annotation databases

EnsemblBacteriaiAAZ21488; AAZ21488; SAR11_0668.
GeneIDi3516914.
KEGGipub:SAR11_0668.
PATRICi31990819. VBICanPel5618_0666.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000084 Genomic DNA. Translation: AAZ21488.1 .
RefSeqi YP_266091.1. NC_007205.1.

3D structure databases

ProteinModelPortali Q4FMV1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 335992.SAR11_0668.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ21488 ; AAZ21488 ; SAR11_0668 .
GeneIDi 3516914.
KEGGi pub:SAR11_0668.
PATRICi 31990819. VBICanPel5618_0666.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci CPEL335992:GH3Z-680-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HTCC1062.

Entry informationi

Entry nameiGCSP_PELUB
AccessioniPrimary (citable) accession number: Q4FMV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: August 30, 2005
Last modified: November 26, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3