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Q4FMV1

- GCSP_PELUB

UniProt

Q4FMV1 - GCSP_PELUB

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Pelagibacter ubique (strain HTCC1062)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (30 Aug 2005)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciCPEL335992:GH3Z-680-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:SAR11_0668
    OrganismiPelagibacter ubique (strain HTCC1062)
    Taxonomic identifieri335992 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSAR11 clusterCandidatus Pelagibacter
    ProteomesiUP000002528: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 952952Glycine dehydrogenase (decarboxylating)PRO_0000227111Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei696 – 6961N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi335992.SAR11_0668.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4FMV1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q4FMV1-1 [UniParc]FASTAAdd to Basket

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    MLKNAQKDFI QRHIGPSVDE QNVMLKELGY QNLDDLIKDT VPEKILLKDD    50
    LDIGDPNSEY KALRKLKDIS KKNKIYSSFI GMGYYGTYTP YVILRNILEN 100
    PGWYTSYTPY QPEVAQGRLE MLLNFQQMII DFTGMDIANA SLLDEGTAAA 150
    EAMGLSYRIS KSESKKVFVS KNCHPQTIDV IKTRAEPLGL EIIVGDEDKD 200
    IKEDIICGII QYPGTLGDIK DPSEAISKIH KFNGKAVLAC DLLALAKLKT 250
    PAELGADIAV GSSQRFGIPM GYGGPHAAFF ATKDEYKRSM PGRIVGVSVD 300
    RHGKKAYRLA LQTREQHIRR DKATSNICTA QALLAIVSAA YAVYHGPQGI 350
    KKIAESVSQL TKNFADKLKQ SGYELYSNEF FDTVTIKTLD KTEKIYKNAL 400
    DQGVNIRKVN SEMLAVSFDE RKNLYRANQL LKIFNCSETI KETMNESLSN 450
    IPKNLLRTST YLDHPVFNSY HSETEMLRYL KKLEDSDIAL NKSMIALGSC 500
    TMKLNAVAEM IPVTWKEFSQ PHPFSPVEQM DGYRELFTDL KNWLRSITGF 550
    SGVSLQPNAG AQGEFAGLMV IRKFHEKNGE TNRNVCLIPS SAHGTNPASA 600
    QMVGMKVVVV KCDQYGNVDY EDLKNKAEEH SENLAALMVT YPSTHGVFEE 650
    KITDICELIH NHGGQVYMDG ANLNALVGIA KPGNFGPDVC HINLHKTFCI 700
    PHGGGGPGMG PIACKKHLEI FLPKHSVIKD CGPVTGMGAV SAAPWGSSSI 750
    LSISWMYIKM MGSEGLRKAS QVAILNANYI AHKLKDSFPI LYKGKSGNVA 800
    HECIIDIRTI KSETGITEED IAKRLIDFGY HAPTMSWPVA GTMMIEPTES 850
    ESLSEIDKFC STLIKIKQEI DKIQSGEYDK TDNPLKNAPH THVELTSNKW 900
    DHKYEREEAA YPSEFLRTNK YWPPVGRVDN VYGDKNLFCT CPSMEEYEDT 950
    AA 952
    Length:952
    Mass (Da):106,007
    Last modified:August 30, 2005 - v1
    Checksum:i106AE6F72ABC7B87
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000084 Genomic DNA. Translation: AAZ21488.1.
    RefSeqiYP_266091.1. NC_007205.1.

    Genome annotation databases

    EnsemblBacteriaiAAZ21488; AAZ21488; SAR11_0668.
    GeneIDi3516914.
    KEGGipub:SAR11_0668.
    PATRICi31990819. VBICanPel5618_0666.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000084 Genomic DNA. Translation: AAZ21488.1 .
    RefSeqi YP_266091.1. NC_007205.1.

    3D structure databases

    ProteinModelPortali Q4FMV1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 335992.SAR11_0668.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ21488 ; AAZ21488 ; SAR11_0668 .
    GeneIDi 3516914.
    KEGGi pub:SAR11_0668.
    PATRICi 31990819. VBICanPel5618_0666.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci CPEL335992:GH3Z-680-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HTCC1062.

    Entry informationi

    Entry nameiGCSP_PELUB
    AccessioniPrimary (citable) accession number: Q4FMV1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: August 30, 2005
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3