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Q4FMV1

- GCSP_PELUB

UniProt

Q4FMV1 - GCSP_PELUB

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Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, SAR11_0668
Organism
Pelagibacter ubique (strain HTCC1062)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciCPEL335992:GH3Z-680-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:SAR11_0668
OrganismiPelagibacter ubique (strain HTCC1062)
Taxonomic identifieri335992 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSAR11 clusterCandidatus Pelagibacter
ProteomesiUP000002528: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 952952Glycine dehydrogenase (decarboxylating)UniRule annotationPRO_0000227111Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei696 – 6961N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi335992.SAR11_0668.

Structurei

3D structure databases

ProteinModelPortaliQ4FMV1.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4FMV1-1 [UniParc]FASTAAdd to Basket

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MLKNAQKDFI QRHIGPSVDE QNVMLKELGY QNLDDLIKDT VPEKILLKDD    50
LDIGDPNSEY KALRKLKDIS KKNKIYSSFI GMGYYGTYTP YVILRNILEN 100
PGWYTSYTPY QPEVAQGRLE MLLNFQQMII DFTGMDIANA SLLDEGTAAA 150
EAMGLSYRIS KSESKKVFVS KNCHPQTIDV IKTRAEPLGL EIIVGDEDKD 200
IKEDIICGII QYPGTLGDIK DPSEAISKIH KFNGKAVLAC DLLALAKLKT 250
PAELGADIAV GSSQRFGIPM GYGGPHAAFF ATKDEYKRSM PGRIVGVSVD 300
RHGKKAYRLA LQTREQHIRR DKATSNICTA QALLAIVSAA YAVYHGPQGI 350
KKIAESVSQL TKNFADKLKQ SGYELYSNEF FDTVTIKTLD KTEKIYKNAL 400
DQGVNIRKVN SEMLAVSFDE RKNLYRANQL LKIFNCSETI KETMNESLSN 450
IPKNLLRTST YLDHPVFNSY HSETEMLRYL KKLEDSDIAL NKSMIALGSC 500
TMKLNAVAEM IPVTWKEFSQ PHPFSPVEQM DGYRELFTDL KNWLRSITGF 550
SGVSLQPNAG AQGEFAGLMV IRKFHEKNGE TNRNVCLIPS SAHGTNPASA 600
QMVGMKVVVV KCDQYGNVDY EDLKNKAEEH SENLAALMVT YPSTHGVFEE 650
KITDICELIH NHGGQVYMDG ANLNALVGIA KPGNFGPDVC HINLHKTFCI 700
PHGGGGPGMG PIACKKHLEI FLPKHSVIKD CGPVTGMGAV SAAPWGSSSI 750
LSISWMYIKM MGSEGLRKAS QVAILNANYI AHKLKDSFPI LYKGKSGNVA 800
HECIIDIRTI KSETGITEED IAKRLIDFGY HAPTMSWPVA GTMMIEPTES 850
ESLSEIDKFC STLIKIKQEI DKIQSGEYDK TDNPLKNAPH THVELTSNKW 900
DHKYEREEAA YPSEFLRTNK YWPPVGRVDN VYGDKNLFCT CPSMEEYEDT 950
AA 952
Length:952
Mass (Da):106,007
Last modified:August 30, 2005 - v1
Checksum:i106AE6F72ABC7B87
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000084 Genomic DNA. Translation: AAZ21488.1.
RefSeqiYP_266091.1. NC_007205.1.

Genome annotation databases

EnsemblBacteriaiAAZ21488; AAZ21488; SAR11_0668.
GeneIDi3516914.
KEGGipub:SAR11_0668.
PATRICi31990819. VBICanPel5618_0666.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000084 Genomic DNA. Translation: AAZ21488.1 .
RefSeqi YP_266091.1. NC_007205.1.

3D structure databases

ProteinModelPortali Q4FMV1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 335992.SAR11_0668.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ21488 ; AAZ21488 ; SAR11_0668 .
GeneIDi 3516914.
KEGGi pub:SAR11_0668.
PATRICi 31990819. VBICanPel5618_0666.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci CPEL335992:GH3Z-680-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HTCC1062.

Entry informationi

Entry nameiGCSP_PELUB
AccessioniPrimary (citable) accession number: Q4FMV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: August 30, 2005
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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