Q4FMR1 (KGUA_PELUB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Guanylate kinase
EC=2.7.4.8

Alternative name(s):
GMP kinase

Gene names

Name:	gmk
Ordered Locus Names:	SAR11_0709

Organism

Pelagibacter ubique (strain HTCC1062) [Complete proteome] [HAMAP]

Taxonomic identifier

335992 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › unclassified Alphaproteobacteria › SAR11 cluster › Candidatus Pelagibacter › Pelagibacter ubique

Protein attributes

Sequence length	210 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity. HAMAP-Rule MF_00328
Catalytic activity	ATP + GMP = ADP + GDP. HAMAP-Rule MF_00328
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	purine nucleotide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW guanylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 210	210	Guanylate kinase HAMAP-Rule MF_00328		PRO_0000266363
Regions
	Domain	7 – 186	180	Guanylate kinase-like
	Nucleotide binding	14 – 21	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4FMR1 [UniParc]. Last modified August 30, 2005. Version 1. Checksum: 649DC5282D2E47A9	FASTA	210	24,718
	10 20 30 40 50 60 MSIKKDGIMV ILSSPSGAGK TTLVKLLSKN KNFHISISHT TRKPRLNEIA DKDYYFVDHD 70 80 90 100 110 120 KFENLIKNEE FLEYAKVFNH LYGTTRTPVI EKLEKGENVI FDIDWQGADQ IKNKKLNYKL 130 140 150 160 170 180 ITFFILPPSK EILFERLSNR DMKDKLIVEE RMKEFSRDVL HWINYDYVII NDDLEECYSK 190 200 210 ISSLIDAEIN NGSKDYDKDF IRKHVEKLTS

References

[1]

"Genome streamlining in a cosmopolitan oceanic bacterium." Giovannoni S.J., Tripp H.J., Givan S., Podar M., Vergin K.L., Baptista D., Bibbs L., Eads J., Richardson T.H., Noordewier M., Rappe M.S., Short J.M., Carrington J.C., Mathur E.J. Science 309:1242-1245(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HTCC1062.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000084 Genomic DNA. Translation: AAZ21528.1.
RefSeq	YP_266131.1. NC_007205.1.
3D structure databases
HSSP	HSSP built from PDB template 2AN9 based on UniProtKB P60546.
ProteinModelPortal	Q4FMR1.
ModBase	Search...
Protein-protein interaction databases
STRING	335992.SAR11_0709.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAZ21528; AAZ21528; SAR11_0709.
GeneID	3516837.
KEGG	pub:SAR11_0709.
PATRIC	31990901. VBICanPel5618_0707.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0194.
HOGENOM	HOG000037638.
KO	K00942.
OMA	FVIINEL.
Enzyme and pathway databases
BioCyc	CPEL335992:GH3Z-703-MONOMER.
Family and domain databases
HAMAP	MF_00328. Guanylate_kinase.
InterPro	IPR008144. Guanylate_kin. IPR008145. Guanylate_kin/L-typ_Ca_channel. IPR017665. Guanylate_kinase_sub. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR03263. guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. False negative. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGUA_PELUB

Accession

Primary (citable) accession number: Q4FMR1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	August 30, 2005
Last modified:	May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program