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Q4FMH0

- HISX2_PELUB

UniProt

Q4FMH0 - HISX2_PELUB

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Protein

Histidinol dehydrogenase 2

Gene
hisD2, SAR11_0801
Organism
Pelagibacter ubique (strain HTCC1062)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei228 – 2281Substrate By similarity
Metal bindingi250 – 2501Zinc By similarity
Binding sitei250 – 2501Substrate By similarity
Metal bindingi253 – 2531Zinc By similarity
Binding sitei253 – 2531Substrate By similarity
Active sitei320 – 3201Proton acceptor By similarity
Active sitei321 – 3211Proton acceptor By similarity
Binding sitei321 – 3211Substrate By similarity
Metal bindingi354 – 3541Zinc By similarity
Binding sitei354 – 3541Substrate By similarity
Binding sitei408 – 4081Substrate By similarity
Metal bindingi413 – 4131Zinc By similarity
Binding sitei413 – 4131Substrate By similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciCPEL335992:GH3Z-811-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase 2 (EC:1.1.1.23)
Short name:
HDH 2
Gene namesi
Name:hisD2
Ordered Locus Names:SAR11_0801
OrganismiPelagibacter ubique (strain HTCC1062)
Taxonomic identifieri335992 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSAR11 clusterCandidatus Pelagibacter
ProteomesiUP000002528: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 428428Histidinol dehydrogenase 2UniRule annotationPRO_0000135810Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi335992.SAR11_0801.

Structurei

3D structure databases

ProteinModelPortaliQ4FMH0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK15509.
OMAiISRLEGM.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4FMH0-1 [UniParc]FASTAAdd to Basket

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MAITYLKKSP KTSSTDDTKT TGIVQDLLKN IETTKEQGCI DLTKKFDKYD    50
GEIIVSKERI EEIKKTLDQK TKDDVQFSYE RVRKFAEAQL KNYGQDFEVE 100
LSDGLFAGQK LIPVNTAGCY VPGGRYAHIA SAVMSVTTAK VAGVKNVIAC 150
SPPKEGVGAH PTIIYTADLC GADVILNLGG VPAIAAMTNG LFNNPPADII 200
VGPGNQFVAE AKRILFGKVG IDLFAGPTEI GIIADAKADP EIVAVDLVGQ 250
AEHGYNSPCW LYTTSKELAE KVMKRVPELI AELPEVPRTN ADAAWRDYGE 300
VILCDTDEEM ATISDEYAPE HLEVQTENLE WFHKRLTNYG SLFIGEETTV 350
AYGDKCSGTN HILPTKGAGR YTGGLFVGKF VKTLSFQRMT KESTELVGAA 400
AARISRYEGM EAHARTGDVR LKKYGYSS 428
Length:428
Mass (Da):46,658
Last modified:August 30, 2005 - v1
Checksum:i0DE1C63534A76B41
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000084 Genomic DNA. Translation: AAZ21619.1.
RefSeqiYP_266222.1. NC_007205.1.

Genome annotation databases

EnsemblBacteriaiAAZ21619; AAZ21619; SAR11_0801.
GeneIDi3516715.
KEGGipub:SAR11_0801.
PATRICi31991087. VBICanPel5618_0800.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000084 Genomic DNA. Translation: AAZ21619.1 .
RefSeqi YP_266222.1. NC_007205.1.

3D structure databases

ProteinModelPortali Q4FMH0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 335992.SAR11_0801.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ21619 ; AAZ21619 ; SAR11_0801 .
GeneIDi 3516715.
KEGGi pub:SAR11_0801.
PATRICi 31991087. VBICanPel5618_0800.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K15509.
OMAi ISRLEGM.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci CPEL335992:GH3Z-811-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HTCC1062.

Entry informationi

Entry nameiHISX2_PELUB
AccessioniPrimary (citable) accession number: Q4FMH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: August 30, 2005
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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