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Q4FMH0

- HISX2_PELUB

UniProt

Q4FMH0 - HISX2_PELUB

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Protein

Histidinol dehydrogenase 2

Gene

hisD2

Organism
Pelagibacter ubique (strain HTCC1062)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei228 – 2281SubstrateUniRule annotation
Metal bindingi250 – 2501ZincUniRule annotation
Binding sitei250 – 2501SubstrateUniRule annotation
Metal bindingi253 – 2531ZincUniRule annotation
Binding sitei253 – 2531SubstrateUniRule annotation
Active sitei320 – 3201Proton acceptorUniRule annotation
Active sitei321 – 3211Proton acceptorUniRule annotation
Binding sitei321 – 3211SubstrateUniRule annotation
Metal bindingi354 – 3541ZincUniRule annotation
Binding sitei354 – 3541SubstrateUniRule annotation
Binding sitei408 – 4081SubstrateUniRule annotation
Metal bindingi413 – 4131ZincUniRule annotation
Binding sitei413 – 4131SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciCPEL335992:GH3Z-811-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase 2UniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDH 2UniRule annotation
Gene namesi
Name:hisD2UniRule annotation
Ordered Locus Names:SAR11_0801
OrganismiPelagibacter ubique (strain HTCC1062)
Taxonomic identifieri335992 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSAR11 clusterCandidatus Pelagibacter
ProteomesiUP000002528: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 428428Histidinol dehydrogenase 2PRO_0000135810Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi335992.SAR11_0801.

Structurei

3D structure databases

ProteinModelPortaliQ4FMH0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK15509.
OMAiISRLEGM.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4FMH0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAITYLKKSP KTSSTDDTKT TGIVQDLLKN IETTKEQGCI DLTKKFDKYD
60 70 80 90 100
GEIIVSKERI EEIKKTLDQK TKDDVQFSYE RVRKFAEAQL KNYGQDFEVE
110 120 130 140 150
LSDGLFAGQK LIPVNTAGCY VPGGRYAHIA SAVMSVTTAK VAGVKNVIAC
160 170 180 190 200
SPPKEGVGAH PTIIYTADLC GADVILNLGG VPAIAAMTNG LFNNPPADII
210 220 230 240 250
VGPGNQFVAE AKRILFGKVG IDLFAGPTEI GIIADAKADP EIVAVDLVGQ
260 270 280 290 300
AEHGYNSPCW LYTTSKELAE KVMKRVPELI AELPEVPRTN ADAAWRDYGE
310 320 330 340 350
VILCDTDEEM ATISDEYAPE HLEVQTENLE WFHKRLTNYG SLFIGEETTV
360 370 380 390 400
AYGDKCSGTN HILPTKGAGR YTGGLFVGKF VKTLSFQRMT KESTELVGAA
410 420
AARISRYEGM EAHARTGDVR LKKYGYSS
Length:428
Mass (Da):46,658
Last modified:August 30, 2005 - v1
Checksum:i0DE1C63534A76B41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000084 Genomic DNA. Translation: AAZ21619.1.
RefSeqiYP_266222.1. NC_007205.1.

Genome annotation databases

EnsemblBacteriaiAAZ21619; AAZ21619; SAR11_0801.
GeneIDi3516715.
KEGGipub:SAR11_0801.
PATRICi31991087. VBICanPel5618_0800.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000084 Genomic DNA. Translation: AAZ21619.1 .
RefSeqi YP_266222.1. NC_007205.1.

3D structure databases

ProteinModelPortali Q4FMH0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 335992.SAR11_0801.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ21619 ; AAZ21619 ; SAR11_0801 .
GeneIDi 3516715.
KEGGi pub:SAR11_0801.
PATRICi 31991087. VBICanPel5618_0800.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K15509.
OMAi ISRLEGM.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci CPEL335992:GH3Z-811-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HTCC1062.

Entry informationi

Entry nameiHISX2_PELUB
AccessioniPrimary (citable) accession number: Q4FMH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: August 30, 2005
Last modified: November 26, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3