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Q4FMH0

- HISX2_PELUB

UniProt

Q4FMH0 - HISX2_PELUB

Protein

Histidinol dehydrogenase 2

Gene

hisD2

Organism
Pelagibacter ubique (strain HTCC1062)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (30 Aug 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei228 – 2281SubstrateUniRule annotation
    Metal bindingi250 – 2501ZincUniRule annotation
    Binding sitei250 – 2501SubstrateUniRule annotation
    Metal bindingi253 – 2531ZincUniRule annotation
    Binding sitei253 – 2531SubstrateUniRule annotation
    Active sitei320 – 3201Proton acceptorUniRule annotation
    Active sitei321 – 3211Proton acceptorUniRule annotation
    Binding sitei321 – 3211SubstrateUniRule annotation
    Metal bindingi354 – 3541ZincUniRule annotation
    Binding sitei354 – 3541SubstrateUniRule annotation
    Binding sitei408 – 4081SubstrateUniRule annotation
    Metal bindingi413 – 4131ZincUniRule annotation
    Binding sitei413 – 4131SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciCPEL335992:GH3Z-811-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenase 2UniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDH 2UniRule annotation
    Gene namesi
    Name:hisD2UniRule annotation
    Ordered Locus Names:SAR11_0801
    OrganismiPelagibacter ubique (strain HTCC1062)
    Taxonomic identifieri335992 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSAR11 clusterCandidatus Pelagibacter
    ProteomesiUP000002528: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 428428Histidinol dehydrogenase 2PRO_0000135810Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi335992.SAR11_0801.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4FMH0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK15509.
    OMAiISRLEGM.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4FMH0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAITYLKKSP KTSSTDDTKT TGIVQDLLKN IETTKEQGCI DLTKKFDKYD    50
    GEIIVSKERI EEIKKTLDQK TKDDVQFSYE RVRKFAEAQL KNYGQDFEVE 100
    LSDGLFAGQK LIPVNTAGCY VPGGRYAHIA SAVMSVTTAK VAGVKNVIAC 150
    SPPKEGVGAH PTIIYTADLC GADVILNLGG VPAIAAMTNG LFNNPPADII 200
    VGPGNQFVAE AKRILFGKVG IDLFAGPTEI GIIADAKADP EIVAVDLVGQ 250
    AEHGYNSPCW LYTTSKELAE KVMKRVPELI AELPEVPRTN ADAAWRDYGE 300
    VILCDTDEEM ATISDEYAPE HLEVQTENLE WFHKRLTNYG SLFIGEETTV 350
    AYGDKCSGTN HILPTKGAGR YTGGLFVGKF VKTLSFQRMT KESTELVGAA 400
    AARISRYEGM EAHARTGDVR LKKYGYSS 428
    Length:428
    Mass (Da):46,658
    Last modified:August 30, 2005 - v1
    Checksum:i0DE1C63534A76B41
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000084 Genomic DNA. Translation: AAZ21619.1.
    RefSeqiYP_266222.1. NC_007205.1.

    Genome annotation databases

    EnsemblBacteriaiAAZ21619; AAZ21619; SAR11_0801.
    GeneIDi3516715.
    KEGGipub:SAR11_0801.
    PATRICi31991087. VBICanPel5618_0800.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000084 Genomic DNA. Translation: AAZ21619.1 .
    RefSeqi YP_266222.1. NC_007205.1.

    3D structure databases

    ProteinModelPortali Q4FMH0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 335992.SAR11_0801.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ21619 ; AAZ21619 ; SAR11_0801 .
    GeneIDi 3516715.
    KEGGi pub:SAR11_0801.
    PATRICi 31991087. VBICanPel5618_0800.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K15509.
    OMAi ISRLEGM.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci CPEL335992:GH3Z-811-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HTCC1062.

    Entry informationi

    Entry nameiHISX2_PELUB
    AccessioniPrimary (citable) accession number: Q4FMH0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: August 30, 2005
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3