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Q4FLP6

- PANC_PELUB

UniProt

Q4FLP6 - PANC_PELUB

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Protein
Pantothenate synthetase
Gene
panC, SAR11_1088
Organism
Pelagibacter ubique (strain HTCC1062)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei43 – 431Proton donor By similarity
Binding sitei67 – 671Beta-alanine By similarity
Binding sitei67 – 671Pantoate By similarity
Binding sitei158 – 1581Pantoate By similarity
Binding sitei180 – 1801ATP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi36 – 438ATP By similarity
Nucleotide bindingi152 – 1554ATP By similarity
Nucleotide bindingi188 – 1914ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPEL335992:GH3Z-1096-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetase (EC:6.3.2.1)
Short name:
PS
Alternative name(s):
Pantoate--beta-alanine ligase
Pantoate-activating enzyme
Gene namesi
Name:panC
Ordered Locus Names:SAR11_1088
OrganismiPelagibacter ubique (strain HTCC1062)
Taxonomic identifieri335992 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSAR11 clusterCandidatus Pelagibacter
ProteomesiUP000002528: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 280280Pantothenate synthetaseUniRule annotation
PRO_0000305505Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi335992.SAR11_1088.

Structurei

3D structure databases

ProteinModelPortaliQ4FLP6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175517.
KOiK01918.
OMAiAMQCICI.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4FLP6-1 [UniParc]FASTAAdd to Basket

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MFYLLIFLLQ MKLIKLKTDL IKAIELDRRL GFVPTMGSLH EGHKTLIKTS    50
QKNCKKTLVS IFINPTQFNN KKDYKTYPKN LKQDLSYLKK LKVDYVYLPT 100
IKQIYWKKNN EIKLNKSQKI LCAKFRKGHF EGVLNVLDRF IELISPQKMF 150
MGEKDFQQFF LVKNYIENKY NTKVHVCKTV REKNKLALSS RNSLLNKKSF 200
INSGIIAKKL LSLKNEIKKN KKNYKKMIFY LKEELSKNFD IKIEYLECRN 250
THNLSTNIMN KPFKLFVAYY INNVRLIDNF 280
Length:280
Mass (Da):33,382
Last modified:August 30, 2005 - v1
Checksum:i404EA87518125A94
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000084 Genomic DNA. Translation: AAZ21892.1.
RefSeqiWP_011282151.1. NC_007205.1.
YP_266496.1. NC_007205.1.

Genome annotation databases

EnsemblBacteriaiAAZ21892; AAZ21892; SAR11_1088.
GeneIDi3517249.
KEGGipub:SAR11_1088.
PATRICi31991663. VBICanPel5618_1077.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000084 Genomic DNA. Translation: AAZ21892.1 .
RefSeqi WP_011282151.1. NC_007205.1.
YP_266496.1. NC_007205.1.

3D structure databases

ProteinModelPortali Q4FLP6.
ModBasei Search...

Protein-protein interaction databases

STRINGi 335992.SAR11_1088.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ21892 ; AAZ21892 ; SAR11_1088 .
GeneIDi 3517249.
KEGGi pub:SAR11_1088.
PATRICi 31991663. VBICanPel5618_1077.

Phylogenomic databases

eggNOGi COG0414.
HOGENOMi HOG000175517.
KOi K01918.
OMAi AMQCICI.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci CPEL335992:GH3Z-1096-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HTCC1062.

Entry informationi

Entry nameiPANC_PELUB
AccessioniPrimary (citable) accession number: Q4FLP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: August 30, 2005
Last modified: September 3, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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