Q4FL89 (GCH1_PELUB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase 1
EC=3.5.4.16

Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I

Gene names

Name:	folE
Ordered Locus Names:	SAR11_1245

Organism

Pelagibacter ubique (strain HTCC1062) [Complete proteome] [HAMAP]

Taxonomic identifier

335992 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › unclassified Alphaproteobacteria › SAR11 cluster › Candidatus Pelagibacter › Pelagibacter ubique

Protein attributes

Sequence length	202 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223
Subunit structure	Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity.
Sequence similarities	Belongs to the GTP cyclohydrolase I family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	GTP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	7,8-dihydroneopterin 3'-triphosphate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP tetrahydrofolate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTP cyclohydrolase I activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 202	202	GTP cyclohydrolase 1 HAMAP-Rule MF_00223		PRO_1000058675
Sites
	Metal binding	93	1	Zinc By similarity
	Metal binding	96	1	Zinc By similarity
	Metal binding	164	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4FL89 [UniParc]. Last modified August 30, 2005. Version 1. Checksum: 2EE1EC6785061328	FASTA	202	22,801
	10 20 30 40 50 60 MKLVEDTDSK ILDTKKVSDK EAEEAFKTIL TWMGEDPSRE GLLETPKRVV KAFKEYFGGY 70 80 90 100 110 120 TEDAEKILEK TFGDVEGYDD MVVEKNISVS SHCEHHMAPI VGTAHVAYIP NERVVGLSKL 130 140 150 160 170 180 ARVVEVFSKR LQTQERLTMQ VAQALMTSLD AKGVAVTIDA AHQCMTMRGI KKENATTVTN 190 200 YFLGEFKKDL SVQNRYLRFI SK

References

[1]

"Genome streamlining in a cosmopolitan oceanic bacterium." Giovannoni S.J., Tripp H.J., Givan S., Podar M., Vergin K.L., Baptista D., Bibbs L., Eads J., Richardson T.H., Noordewier M., Rappe M.S., Short J.M., Carrington J.C., Mathur E.J. Science 309:1242-1245(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HTCC1062.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000084 Genomic DNA. Translation: AAZ22049.1.
RefSeq	YP_266653.1. NC_007205.1.
3D structure databases
HSSP	HSSP built from PDB template 1WM9 based on UniProtKB Q5SH52.
ProteinModelPortal	Q4FL89.
ModBase	Search...
Protein-protein interaction databases
STRING	335992.SAR11_1245.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAZ22049; AAZ22049; SAR11_1245.
GeneID	3517762.
KEGG	pub:SAR11_1245.
PATRIC	31991991. VBICanPel5618_1234.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0302.
HOGENOM	HOG000221222.
KO	K01495.
OMA	QNSSMIT.
Enzyme and pathway databases
BioCyc	CPEL335992:GH3Z-1225-MONOMER.
UniPathway	UPA00848; UER00151.
Family and domain databases
HAMAP	MF_00223. FolE.
InterPro	IPR001474. GTP_CycHdrlase_I. IPR020602. GTP_CycHdrlase_I/CN_OxRdtase. IPR018234. GTP_CycHdrlase_I_CS. [Graphical view]
PANTHER	PTHR11109. PTHR11109. 1 hit.
Pfam	PF01227. GTP_cyclohydroI. 1 hit. [Graphical view]
TIGRFAMs	TIGR00063. folE. 1 hit.
PROSITE	PS00859. GTP_CYCLOHYDROL_1_1. 1 hit. PS00860. GTP_CYCLOHYDROL_1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCH1_PELUB

Accession

Primary (citable) accession number: Q4FL89

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	August 30, 2005
Last modified:	May 1, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program